| Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiae eco1-1 allele. | Mistranslating tRNA identifies a deleterious S213P mutation in the Saccharomyces cerevisiaeeco1-1 allele.
Zhu Y, Berg MD, Yang P, Loll-Krippleber R, Brown GW, Brandl CJ. | 05/22/2021 |
| Functional control of Eco1 through the MCM complex in sister chromatid cohesion. | Functional control of Eco1 through the MCM complex in sister chromatid cohesion.
Yoshimura A, Sutani T, Shirahige K. | 05/1/2021 |
| DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae. | DNA damage induces Yap5-dependent transcription of ECO1/CTF7 in Saccharomyces cerevisiae.
Mfarej MG, Skibbens RV., Free PMC Article | 01/23/2021 |
| The acetyltransferase Eco1 elicits cohesin dimerization during S phase. | The acetyltransferase Eco1 elicits cohesin dimerization during S phase.
Shi D, Zhao S, Zuo MQ, Zhang J, Hou W, Dong MQ, Cao Q, Lou H., Free PMC Article | 12/26/2020 |
| The authors propose that the timing of Eco1 phosphorylation, and potentially that of other DDK substrates, is determined in part by sequestration of DDK at unfired replication origins during S phase. | Firing of Replication Origins Frees Dbf4-Cdc7 to Target Eco1 for Destruction.
Seoane AI, Morgan DO., Free PMC Article | 07/28/2018 |
| Eco1 mediated acetylation regulates PCNA sliding on DNA in the presence of DNA damage, favoring homologous recombination linked to sister-chromatid cohesion. | Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.
Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Côté J. | 10/7/2017 |
| These results also suggest that Eco1 promotes cohesion by modulating the ATPase cycle of DNA-bound cohesin in a state that is permissive for DNA tethering and refractory to Wpl1 inhibition. | The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering.
Çamdere G, Guacci V, Stricklin J, Koshland D., Free PMC Article | 10/8/2016 |
| Eco1p-mediated acetylation promotes establishment by abrogating the ability of Wpl1p to destabilize cohesin binding to chromosomes. | A novel mechanism for the establishment of sister chromatid cohesion by the ECO1 acetyltransferase.
Guacci V, Stricklin J, Bloom MS, Guō X, Bhatter M, Koshland D., Free PMC Article | 08/22/2015 |
| Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase. | Pds5 promotes and protects cohesin acetylation.
Chan KL, Gligoris T, Upcher W, Kato Y, Shirahige K, Nasmyth K, Beckouët F., Free PMC Article | 11/16/2013 |
| the absence of Ctf4 and Chl1, but not of the other factors, causes a synthetic growth defect in cells lacking Eco1. | An Eco1-independent sister chromatid cohesion establishment pathway in S. cerevisiae.
Borges V, Smith DJ, Whitehouse I, Uhlmann F., Free PMC Article | 09/7/2013 |
| Eco1 degradation requires the sequential actions of Cdk1 and two additional kinases, Cdc7-Dbf4 and the GSK-3 homolog Mck1. | Sequential primed kinases create a damage-responsive phosphodegron on Eco1.
Lyons NA, Fonslow BR, Diedrich JK, Yates JR 3rd, Morgan DO., Free PMC Article | 04/6/2013 |
| Acetylation of Mps3 by Eco1 is one of the few regulatory mechanisms known to control nuclear organization. | Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization.
Ghosh S, Gardner JM, Smoyer CJ, Friederichs JM, Unruh JR, Slaughter BD, Alexander R, Chisholm RD, Lee KK, Workman JL, Jaspersen SL., Free PMC Article | 11/17/2012 |
| Data suggest that Cdk1-dependent phosphorylation of Eco1 is a key factor limiting establishment to S phase. | Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.
Lyons NA, Morgan DO., Free PMC Article | 08/6/2011 |
| Eco1 promotes the reciprocal exchange of chromosome arms and maintenance of heterozygosity during mitosis. | Eco1 is important for DNA damage repair in S. cerevisiae.
Lu S, Goering M, Gard S, Xiong B, McNairn AJ, Jaspersen SL, Gerton JL., Free PMC Article | 01/22/2011 |
| Eco1 regulates proteins in the cohesin network through acetylation and plays an important role in the subnuclear organization of chromatin. | Cohesinopathy mutations disrupt the subnuclear organization of chromatin.
Gard S, Light W, Xiong B, Bose T, McNairn AJ, Harris B, Fleharty B, Seidel C, Brickner JH, Gerton JL., Free PMC Article | 01/21/2010 |
| The zinc finger may be a general enhancer of substrate recognition, thereby enhancing the ability of Eco1p to acetylate its substrates above a threshold needed to generate cohesion during DNA replication and repair. | The zinc finger of Eco1 enhances its acetyltransferase activity during sister chromatid cohesion.
Onn I, Guacci V, Koshland DE., Free PMC Article | 01/21/2010 |
| Results provide a model where Eco1p and Wpl1p act as a simple positive and negative regulatory switch controlling cohesion generation. | Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage.
Heidinger-Pauli JM, Unal E, Koshland D., Free PMC Article | 01/21/2010 |
| required for the establishment of sister chromatid cohesion | Chromatid cohesion: acetylation joins the sisters.
Tanaka K, Watanabe Y. | 01/21/2010 |
| Cdc28p CDK acts in sister chromatid cohesion parallel to Ctf7p reactions | Sister chromatid cohesion role for CDC28-CDK in Saccharomyces cerevisiae.
Brands A, Skibbens RV., Free PMC Article | 01/21/2010 |
| study found that the head domain of the Smc3p subunit of cohesin is acetylated by the Eco1p acetyltransferase at two evolutionarily conserved residues, promoting the chromatin-bound cohesin to tether sister chromatids | A molecular determinant for the establishment of sister chromatid cohesion.
Unal E, Heidinger-Pauli JM, Kim W, Guacci V, Onn I, Gygi SP, Koshland DE. | 01/21/2010 |
| findings show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion | Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.
Rolef Ben-Shahar T, Heeger S, Lehane C, East P, Flynn H, Skehel M, Uhlmann F. | 01/21/2010 |
| This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion. | Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast.
Zhang J, Shi X, Li Y, Kim BJ, Jia J, Huang Z, Yang T, Fu X, Jung SY, Wang Y, Zhang P, Kim ST, Pan X, Qin J. | 01/21/2010 |
| During chromatid cohesion establishment, Eco1 is found at the DNA replication fork. | Establishment of sister chromatid cohesion at the S. cerevisiae replication fork.
Lengronne A, McIntyre J, Katou Y, Kanoh Y, Hopfner KP, Shirahige K, Uhlmann F. | 01/21/2010 |
| findings show that cohesion is generated by an Eco1-dependent but replication-independent mechanism in response to double-strand breaks in G(2)/M; Eco1 has 2 functions: a cohesive activity and a conserved acetyltransferase activity | DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).
Unal E, Heidinger-Pauli JM, Koshland D. | 01/21/2010 |