| Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination. | Single-molecule characterization of Sen1 translocation properties provides insights into eukaryotic factor-dependent transcription termination.
Wang S, Han Z, Strick TR., Free PMC Article | 05/9/2024 |
| Sen1 and Rrm3 ensure permissive topological conditions for replication termination. | Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
Choudhary R, Niska-Blakie J, Adhil M, Liberi G, Achar YJ, Giannattasio M, Foiani M. | 08/3/2023 |
| Sen1 is a key regulator of transcription-driven conflicts. | Sen1 is a key regulator of transcription-driven conflicts.
Aiello U, Challal D, Wentzinger G, Lengronne A, Appanah R, Pasero P, Palancade B, Libri D. | 08/27/2022 |
| Modulated termination of non-coding transcription partakes in the regulation of gene expression. | Modulated termination of non-coding transcription partakes in the regulation of gene expression.
Haidara N, Giannini M, Porrua O., Free PMC Article | 05/7/2022 |
| Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast. | Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast.
Turner RE, Harrison PF, Swaminathan A, Kraupner-Taylor CA, Goldie BJ, See M, Peterson AL, Schittenhelm RB, Powell DR, Creek DJ, Dichtl B, Beilharz TH., Free PMC Article | 10/9/2021 |
| Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability. | Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability.
Appanah R, Lones EC, Aiello U, Libri D, De Piccoli G., Free PMC Article | 03/13/2021 |
| Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1. | Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1.
Han Z, Jasnovidova O, Haidara N, Tudek A, Kubicek K, Libri D, Stefl R, Porrua O., Free PMC Article | 12/12/2020 |
| Three sequence motifs in Sen1 that mediate direct interactions with the RNA polymerase II CTD interaction domain (CID) of Nrd1 have been identified. | Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1.
Zhang Y, Chun Y, Buratowski S, Tong L., Free PMC Article | 05/2/2020 |
| A harmless head-on replication-transcription clash resolution requires the fine-tuning of origin firing and coordination among Sen1, Exo1, Mre11 and Mrc1-Ctf4 complexes. | Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription.
Brambati A, Zardoni L, Achar YJ, Piccini D, Galanti L, Colosio A, Foiani M, Liberi G., Free PMC Article | 07/6/2019 |
| RNA polymerase II CTD tyrosine 1 is required for efficient termination by the Nrd1-Nab3-Sen1 pathway by slowing down transcription and suppressing termination defects. | RNA Polymerase II CTD Tyrosine 1 Is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway.
Collin P, Jeronimo C, Poitras C, Robert F. | 06/29/2019 |
| ncRNA levels and coding gene transcription termination are modulated by Sen1 to fulfill critical cell cycle-specific functions. | Cell-Cycle Modulation of Transcription Termination Factor Sen1.
Mischo HE, Chun Y, Harlen KM, Smalec BM, Dhir S, Churchman LS, Buratowski S., Free PMC Article | 02/9/2019 |
| our data link Dbp2p to noncoding RNAs, Sen1p, and R-loops. The transcriptome-wide connection to R-loops provides a unifying theme for diverse cellular roles of Dbp2p | The DEAD-box protein Dbp2p is linked to noncoding RNAs, the helicase Sen1p, and R-loops.
Tedeschi FA, Cloutier SC, Tran EJ, Jankowsky E., Free PMC Article | 01/12/2019 |
| The helicase domain (HD) is sufficient to dissociate the elongation complex (EC) in vitro. Both full-length Sen1 and its HD can translocate along single-stranded RNA and DNA in the 5 to 3 direction. | Biochemical characterization of the helicase Sen1 provides new insights into the mechanisms of non-coding transcription termination.
Han Z, Libri D, Porrua O., Free PMC Article | 10/7/2017 |
| we identify new targets and functions of Sen1-dependent termination, including a role in repression of meiotic genes in vegetative cells. In combination with other recent whole-genome studies on termination of non-coding RNAs, our results provide promising directions for further investigation. | Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome.
Chen X, Poorey K, Carver MN, Müller U, Bekiranov S, Auble DT, Brow DA., Free PMC Article | 07/29/2017 |
| The authors also show that subdomain 1C (the "prong") is an essential element for 5'-3' unwinding of RNA and for Sen1-mediated transcription termination in vitro. | Sen1 has unique structural features grafted on the architecture of the Upf1-like helicase family.
Leonaitė B, Han Z, Basquin J, Bonneau F, Libri D, Porrua O, Conti E., Free PMC Article | 07/15/2017 |
| DNA/RNA helicase Sen1 mutant causes modulation of protein-serine-threonine kinase TOR pathway and autophagy. | Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae.
Sariki SK, Sahu PK, Golla U, Singh V, Azad GK, Tomar RS. | 07/1/2017 |
| Data indicate that mutant of the RNA processing machinery (RNT1), and RNA/DNA helicase SEN1 mutants that are unable to interact with Rnt1p, exhibit a flocculation phenotype. | Flocculation in Saccharomyces cerevisiae is regulated by RNA/DNA helicase Sen1p.
Singh V, Azad GK, Sariki SK, Tomar RS. | 01/30/2016 |
| results are consistent with a model in which Sen1 promotes transcription termination by resolving R-loops. | Saccharomyces cerevisiae Sen1 Helicase Domain Exhibits 5'- to 3'-Helicase Activity with a Preference for Translocation on DNA Rather than RNA.
Martin-Tumasz S, Brow DA., Free PMC Article | 12/19/2015 |
| We provide evidence that this topological stress contributes to recruit and/or stabilize condensin at Pol III-transcribed genes in the absence of Swd2.2 and Sen1 | RNA processing factors Swd2.2 and Sen1 antagonize RNA Pol III-dependent transcription and the localization of condensin at Pol III genes.
Legros P, Malapert A, Niinuma S, Bernard P, Vanoosthuyse V., Free PMC Article | 11/14/2015 |
| Multiple domains of Sen1 are involved in transcription termination. | Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia.
Chen X, Müller U, Sundling KE, Brow DA., Free PMC Article | 06/20/2015 |
| Sen1p recognizes the nascent RNA & hydrolyzes ATP to dissociate the elongation complex. Sen1p-dependent transcription termination is highly specific & does not require the C-terminal domain of RNAPII. | A bacterial-like mechanism for transcription termination by the Sen1p helicase in budding yeast.
Porrua O, Libri D. | 09/14/2013 |
| Study shows that the Sen1/Senataxin DNA/RNA helicase associates with forks, promoting their progression across RNA polymerase II (RNAPII)-transcribed genes. | Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.
Alzu A, Bermejo R, Begnis M, Lucca C, Piccini D, Carotenuto W, Saponaro M, Brambati A, Cocito A, Foiani M, Liberi G., Free PMC Article | 01/26/2013 |
| Analysis of a homogeneous set of several hundreds of artificial, Nrd1-Nab3-Sen1 complex-dependent terminators revealed novel and extended sequence determinants for transcription termination, as well as supermotifs critical for termination. | In vivo SELEX reveals novel sequence and structural determinants of Nrd1-Nab3-Sen1-dependent transcription termination.
Porrua O, Hobor F, Boulay J, Kubicek K, D'Aubenton-Carafa Y, Gudipati RK, Stefl R, Libri D., Free PMC Article | 01/12/2013 |
| transcriptome-wide distribution of termination factors Nrd1, Nab3, and Sen1 is reported. | Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1.
Creamer TJ, Darby MM, Jamonnak N, Schaughency P, Hao H, Wheelan SJ, Corden JL., Free PMC Article | 02/25/2012 |
| show here that Nrd1, Nab3, and Sen1 bind to a number of noncoding RNAs in an unexpected manner | Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing.
Jamonnak N, Creamer TJ, Darby MM, Schaughency P, Wheelan SJ, Corden JL., Free PMC Article | 11/26/2011 |