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    RAD59 Rad59p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851500, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    propose that Rad59 promotes fork progression when Okazaki fragment processing is compromised and counteracts PCNA-K107 mediated cell cycle arrest

    Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.
    Nguyen HD, Becker J, Thu YM, Costanzo M, Koch EN, Smith S, Myung K, Myers CL, Boone C, Bielinsky AK., Free PMC Article

    10/14/2017
    SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination

    SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination.
    Silva S, Altmannova V, Eckert-Boulet N, Kolesar P, Gallina I, Hang L, Chung I, Arneric M, Zhao X, Buron LD, Mortensen UH, Krejci L, Lisby M., Free PMC Article

    05/6/2017
    We show that Rad59-facilitated Y' translocations on X-only telomeres delay the onset of senescence while preparing ground for type I survivor formation.

    Rad59-facilitated acquisition of Y' elements by short telomeres delays the onset of senescence.
    Churikov D, Charifi F, Simon MN, Géli V., Free PMC Article

    11/14/2015
    Findings suggest a Rad52/Rad59-dependent, recombination pathway that could ultimately lead to the removal of faulty flaps in conjunction with cohesion establishment factors.

    Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.
    Lee M, Lee CH, Demin AA, Munashingha PR, Amangyeld T, Kwon B, Formosa T, Seo YS., Free PMC Article

    11/8/2014
    These results suggest that Rad59 influences the rescue of replication lesions by multiple recombination factors.

    Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae.
    Liddell LC, Manthey GM, Owens SN, Fu BX, Bailis AM., Free PMC Article

    07/5/2014
    Data show that RSC physically interacts with the recombination protein Rad59 and functions in homologous recombination.

    RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks.
    Oum JH, Seong C, Kwon Y, Ji JH, Sid A, Ramakrishnan S, Ira G, Malkova A, Sung P, Lee SE, Shim EY., Free PMC Article

    12/17/2011
    at least one role of Rad59 in translocation formation by single-strand annealing is supporting the machinery required for cleavage of non-homologous tails

    RAD59 and RAD1 cooperate in translocation formation by single-strand annealing in Saccharomyces cerevisiae.
    Pannunzio NR, Manthey GM, Bailis AM., Free PMC Article

    04/19/2010
    RAD59 was found to play a particularly significant role in recombination between the short substrates that was partially independent of that of Rad52 DNA Repair and Recombination Protein

    RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae.
    Pannunzio NR, Manthey GM, Bailis AM., Free PMC Article

    01/21/2010
    examined the ssDNA annealing activity of Rad52 and Rad59 proteins and found significant differences in their biochemical properties.

    DNA annealing mediated by Rad52 and Rad59 proteins.
    Wu Y, Sugiyama T, Kowalczykowski SC.

    01/21/2010
    S. cerevisiae Rad59 protein and its eukaryotic counterparts function by binding to single-stranded DNA formed as intermediates of recombination rather than by binding to the unprocessed DNA double-strand break.

    The DNA binding preference of RAD52 and RAD59 proteins: implications for RAD52 and RAD59 protein function in homologous recombination.
    Wu Y, Siino JS, Sugiyama T, Kowalczykowski SC.

    01/21/2010
    Data from this study show that defects in the Rad51-Sgs1-dependent and Sgs1-dependent lesion-bypass pathways activate Rad59-Rad1- and Rad59-dependent pathways, respectively, resulting in uSCR.

    Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells.
    Ui A, Seki M, Ogiwara H, Lai MS, Yamamoto K, Tada S, Enomoto T.

    01/21/2010
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