propose that Rad59 promotes fork progression when Okazaki fragment processing is compromised and counteracts PCNA-K107 mediated cell cycle arrest | Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. Nguyen HD, Becker J, Thu YM, Costanzo M, Koch EN, Smith S, Myung K, Myers CL, Boone C, Bielinsky AK., Free PMC Article | 10/14/2017 |
SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination | SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. Silva S, Altmannova V, Eckert-Boulet N, Kolesar P, Gallina I, Hang L, Chung I, Arneric M, Zhao X, Buron LD, Mortensen UH, Krejci L, Lisby M., Free PMC Article | 05/6/2017 |
We show that Rad59-facilitated Y' translocations on X-only telomeres delay the onset of senescence while preparing ground for type I survivor formation. | Rad59-facilitated acquisition of Y' elements by short telomeres delays the onset of senescence. Churikov D, Charifi F, Simon MN, Géli V., Free PMC Article | 11/14/2015 |
Findings suggest a Rad52/Rad59-dependent, recombination pathway that could ultimately lead to the removal of faulty flaps in conjunction with cohesion establishment factors. | Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing. Lee M, Lee CH, Demin AA, Munashingha PR, Amangyeld T, Kwon B, Formosa T, Seo YS., Free PMC Article | 11/8/2014 |
These results suggest that Rad59 influences the rescue of replication lesions by multiple recombination factors. | Alleles of the homologous recombination gene, RAD59, identify multiple responses to disrupted DNA replication in Saccharomyces cerevisiae. Liddell LC, Manthey GM, Owens SN, Fu BX, Bailis AM., Free PMC Article | 07/5/2014 |
Data show that RSC physically interacts with the recombination protein Rad59 and functions in homologous recombination. | RSC facilitates Rad59-dependent homologous recombination between sister chromatids by promoting cohesin loading at DNA double-strand breaks. Oum JH, Seong C, Kwon Y, Ji JH, Sid A, Ramakrishnan S, Ira G, Malkova A, Sung P, Lee SE, Shim EY., Free PMC Article | 12/17/2011 |
at least one role of Rad59 in translocation formation by single-strand annealing is supporting the machinery required for cleavage of non-homologous tails | RAD59 and RAD1 cooperate in translocation formation by single-strand annealing in Saccharomyces cerevisiae. Pannunzio NR, Manthey GM, Bailis AM., Free PMC Article | 04/19/2010 |
RAD59 was found to play a particularly significant role in recombination between the short substrates that was partially independent of that of Rad52 DNA Repair and Recombination Protein | RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae. Pannunzio NR, Manthey GM, Bailis AM., Free PMC Article | 01/21/2010 |
examined the ssDNA annealing activity of Rad52 and Rad59 proteins and found significant differences in their biochemical properties. | DNA annealing mediated by Rad52 and Rad59 proteins. Wu Y, Sugiyama T, Kowalczykowski SC. | 01/21/2010 |
S. cerevisiae Rad59 protein and its eukaryotic counterparts function by binding to single-stranded DNA formed as intermediates of recombination rather than by binding to the unprocessed DNA double-strand break. | The DNA binding preference of RAD52 and RAD59 proteins: implications for RAD52 and RAD59 protein function in homologous recombination. Wu Y, Siino JS, Sugiyama T, Kowalczykowski SC. | 01/21/2010 |
Data from this study show that defects in the Rad51-Sgs1-dependent and Sgs1-dependent lesion-bypass pathways activate Rad59-Rad1- and Rad59-dependent pathways, respectively, resulting in uSCR. | Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells. Ui A, Seki M, Ogiwara H, Lai MS, Yamamoto K, Tada S, Enomoto T. | 01/21/2010 |