| The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis. | The transcriptional regulator Ume6 is a major driver of early gene expression during gametogenesis.
Harris A, Ünal E., Free PMC Article | 11/15/2023 |
| RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in rho(0) cells of Saccharomyces cerevisiae. | RPD3 and UME6 are involved in the activation of PDR5 transcription and pleiotropic drug resistance in ρ(0) cells of Saccharomyces cerevisiae.
Yamada Y., Free PMC Article | 01/22/2022 |
| Ume6 Acts as a Stable Platform To Coordinate Repression and Activation of Early Meiosis-Specific Genes in Saccharomyces cerevisiae. | Ume6 Acts as a Stable Platform To Coordinate Repression and Activation of Early Meiosis-Specific Genes in Saccharomyces cerevisiae.
Raithatha SA, Vaza S, Islam MT, Greenwood B, Stuart DT., Free PMC Article | 07/24/2021 |
| We also present evidence that indicates Rim11/Ume6 works independently but in parallel with that of checkpoint inhibition, dNTP regulation, and sister-chromatid recombination. In conclusion, our results establish Rim11, Ume6, the histone deacetylase complex Sin3-Rpd3 and Sml1 as new factors important in the events of faulty lagging strand synthesis. | GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.
Demin AA, Lee M, Lee CH, Seo YS., Free PMC Article | 07/15/2017 |
| evidence that the Rpd3/Sin3/Ume6 histone deacetylase complex, which represses meiotic genes during mitosis, also prevents the induction of BOI1's 5'-extended isoform in mitosis by direct binding of Ume6 to its URS1 target | The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae.
Liu Y, Stuparevic I, Xie B, Becker E, Law MJ, Primig M. | 02/6/2016 |
| identifies novel Ume6 repressed genes during growth and development and reveals a strong effect of the carbon source on the derepression pattern of transcripts in growing and developmentally arrested ume6/ume6 mutant cells | Global alterations of the transcriptional landscape during yeast growth and development in the absence of Ume6-dependent chromatin modification.
Lardenois A, Becker E, Walther T, Law MJ, Xie B, Demougin P, Strich R, Primig M., Free PMC Article | 12/12/2015 |
| acetylation inhibits Ume6p binding by electrostatic repulsion | Acetylation of the transcriptional repressor Ume6p allows efficient promoter release and timely induction of the meiotic transient transcription program in yeast.
Law MJ, Mallory MJ, Dunbrack RL Jr, Strich R., Free PMC Article | 03/22/2014 |
| Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p. | Gcn5p-dependent acetylation induces degradation of the meiotic transcriptional repressor Ume6p.
Mallory MJ, Law MJ, Sterner DE, Berger SL, Strich R., Free PMC Article | 11/24/2012 |
| Ume6 is a negative regulator of ATG8 transcription, which acts along with a histone deacetylase complex including Sin3 and Rpd3 to regulate Atg8 levels | Ume6 transcription factor is part of a signaling cascade that regulates autophagy.
Bartholomew CR, Suzuki T, Du Z, Backues SK, Jin M, Lynch-Day MA, Umekawa M, Kamath A, Zhao M, Xie Z, Inoki K, Klionsky DJ., Free PMC Article | 10/6/2012 |
| The present study reveals that spores derived from a ume6 null homozygous diploid fail to germinate. | Ume6p is required for germination and early colony development of yeast ascospores.
Strich R, Khakhina S, Mallory MJ., Free PMC Article | 04/23/2011 |
| Ume6p was found to be a positive regulator of PIS1 gene expression. | Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p.
Jani NM, Lopes JM. | 01/21/2010 |
| These results indicate that Ume6p degradation is required for normal meiotic gene induction and meiotic progression. | Meiosis-specific destruction of the Ume6p repressor by the Cdc20-directed APC/C.
Mallory MJ, Cooper KF, Strich R., Free PMC Article | 01/21/2010 |
| sequence-specific repressors, Ume6 is stably associated with Rpd3L | Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.
Carrozza MJ, Florens L, Swanson SK, Shia WJ, Anderson S, Yates J, Washburn MP, Workman JL. | 01/21/2010 |