| Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast. | Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
Haluska C, Jin F, Wang Y., Free PMC Article | 03/26/2022 |
| Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. | Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Philip J, Örd M, Silva A, Singh S, Diffley JF, Remus D, Loog M, Ikui AE., Free PMC Article | 03/5/2022 |
| PP2A(Cdc55) dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae. | PP2A(Cdc55) dephosphorylates Pds1 and inhibits spindle elongation in S. cerevisiae.
Khondker S, Kajjo S, Chandler-Brown D, Skotheim J, Rudner A, Ikui AE., Free PMC Article | 06/26/2021 |
| Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit. | Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit.
Touati SA, Hofbauer L, Jones AW, Snijders AP, Kelly G, Uhlmann F., Free PMC Article | 09/19/2020 |
| Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism. | Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism.
Matmati N, Hassan BH, Ren J, Shamssedine AA, Jeong E, Shariff B, Snider J, Rødkær SV, Chen G, Mohanty BK, Zheng WJ, Obeid LM, Røssel-Larsen M, Færgeman NJ, Hannun YA., Free PMC Article | 08/29/2020 |
| CDC55 role in the regulation pericentric cohesin and anaphase onset. | Cdk1 phosphorylation of Esp1/Separase functions with PP2A and Slk19 to regulate pericentric Cohesin and anaphase onset.
Lianga N, Doré C, Kennedy EK, Yeh E, Williams EC, Fortinez CM, Wang A, Bloom KS, Rudner AD., Free PMC Article | 07/14/2018 |
| Cdc55 is required for reductional chromosome segregation during achiasmate meiosis. | PP2A(Cdc55)'s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.
Kerr GW, Wong JH, Arumugam P., Free PMC Article | 04/28/2018 |
| Results show that the phosphatase PP2ACdc55 counteracts and thereby delays cell-cycle phosphorylation by cyclin-dependent kinase specifically on threonine, but not serine, phosphorylation sites. | PP2A(Cdc55) Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation.
Godfrey M, Touati SA, Kataria M, Jones A, Snijders AP, Uhlmann F., Free PMC Article | 09/9/2017 |
| orchestrated action of PP2A antagonizes Atg13 phosphorylation and promotes autophagy after the inactivation of TORC1 | Orchestrated Action of PP2A Antagonizes Atg13 Phosphorylation and Promotes Autophagy after the Inactivation of TORC1.
Yeasmin AM, Waliullah TM, Kondo A, Kaneko A, Koike N, Ushimaru T., Free PMC Article | 07/15/2017 |
| Constitutively active Pkc1 can drive cells through a mitotic checkpoint arrest, which suggests that Pkc1-dependent activation of PP2A(Cdc55) plays a critical role in checkpoint signaling. | Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.
Thai V, Dephoure N, Weiss A, Ferguson J, Leitao R, Gygi SP, Kellogg DR., Free PMC Article | 06/24/2017 |
| The PP2A(Cdc55) specifies Rho1 signaling output and that reciprocal antagonism between Rho1-PP2A(Cdc55) and Rho1-Pkc1 explains how only one signaling pathway is robustly activated at a time. | Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase.
Jonasson EM, Rossio V, Hatakeyama R, Abe M, Ohya Y, Yoshida S., Free PMC Article | 05/21/2016 |
| we propose a clear picture of how PP2A(Cdc55) functions affect the regulation of various MEN components, contributing to mitotic exit. | Dual Regulation of the mitotic exit network (MEN) by PP2A-Cdc55 phosphatase.
Baro B, Rodriguez-Rodriguez JA, Calabria I, Hernáez ML, Gil C, Queralt E., Free PMC Article | 08/23/2014 |
| Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A | Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.
Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, Branton PE., Free PMC Article | 06/28/2014 |
| We conclude that Greatwall, endosulfines, and PP2A are part of a regulatory module that has been conserved during evolution irrespective of PP2A function in the control of mitosis | Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.
Juanes MA, Khoueiry R, Kupka T, Castro A, Mudrak I, Ogris E, Lorca T, Piatti S., Free PMC Article | 01/11/2014 |
| PP2A(Cdc55) regulates G1 cyclin stability. | PP2A(Cdc55) regulates G1 cyclin stability.
McCourt P, Gallo-Ebert C, Gonghong Y, Jiang Y, Nickels JT Jr., Free PMC Article | 11/16/2013 |
| Methionine and S-adenosylmethionine levels represent a critical gauge of amino acid availability that is sensed via the methylation of PP2A to reciprocally regulate cell growth and autophagy. | Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A.
Sutter BM, Wu X, Laxman S, Tu BP., Free PMC Article | 10/19/2013 |
| Cdc55 phosphatase is not involved in cytosolic stress signal perception but is involved in a specific intranuclear mechanism to regulate Msn2 and Msn4 nuclear accumulation and chromatin association under stress conditions. | Yeast protein phosphatase 2A-Cdc55 regulates the transcriptional response to hyperosmolarity stress by regulating Msn2 and Msn4 chromatin recruitment.
Reiter W, Klopf E, De Wever V, Anrather D, Petryshyn A, Roetzer A, Niederacher G, Roitinger E, Dohnal I, Görner W, Mechtler K, Brocard C, Schüller C, Ammerer G., Free PMC Article | 04/13/2013 |
| Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif. | Zds1 regulates PP2A(Cdc55) activity and Cdc14 activation during mitotic exit through its Zds_C motif.
Calabria I, Baro B, Rodriguez-Rodriguez JA, Russiñol N, Queralt E., Free PMC Article | 01/26/2013 |
| Data show a mechanism through which the conserved Pkh-Ypk kinase cascade and Cdc55-PP2A facilitate rapid, transient sphingolipid production in response to heat stress through Orm protein phosphoregulation. | Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.
Sun Y, Miao Y, Yamane Y, Zhang C, Shokat KM, Takematsu H, Kozutsumi Y, Drubin DG., Free PMC Article | 10/13/2012 |
| Separase acts directly on Scc1 and also indirectly, through inhibition of PP2A(Cdc55), to stimulate cohesin cleavage, providing a feedforward loop that may contribute to a robust and timely anaphase. | Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.
Yaakov G, Thorn K, Morgan DO., Free PMC Article | 10/13/2012 |
| A PP2A (Cdc) containing the human B/55 family B subunit ortholog Cdc55 is required for progression hrough meiosis I. | PP2A (Cdc)⁵⁵ is required for multiple events during meiosis I.
Nolt JK, Rice LM, Gallo-Ebert C, Bisher ME, Nickels JT. | 03/17/2012 |
| PP2A(Cdc55) sets a threshold that limits activation of Wee1, thereby allowing a low constant level of Cdk1 activity to escape Wee1 inhibition in early mitosis. | A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast.
Harvey SL, Enciso G, Dephoure N, Gygi SP, Gunawardena J, Kellogg DR., Free PMC Article | 02/11/2012 |
| Cdc55p/Zds2p module has a function in the regulation of the Swe1p-dependent G2/M checkpoint. | Zds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain.
Yasutis K, Vignali M, Ryder M, Tameire F, Dighe SA, Fields S, Kozminski KG., Free PMC Article | 08/20/2011 |
| regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast | Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast.
Rossio V, Yoshida S., Free PMC Article | 07/9/2011 |
| synthetic lethal interaction between loss of CDC55 and gene deletions lethal with rvs161, all of which function in endocytosis. | Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis.
McCourt PC, Morgan JM, Nickels JT Jr., Free PMC Article | 01/21/2010 |