| DNA-translocation-independent role of INO80 remodeler in DNA damage repairs. | DNA-translocation-independent role of INO80 remodeler in DNA damage repairs.
Sokolova V, Lee G, Mullins A, Mody P, Watanabe S, Tan D., Free PMC Article | 01/5/2024 |
| Arp8 engages N-actin in a manner distinct from that of other actin-fold proteins and thereby specifies recruitment of the Arp4-N-actin heterodimer to a segmented scaffold of the helicase-SANT-associated (HSA) domain of Ino80 | The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling.
Knoll KR, Eustermann S, Niebauer V, Oberbeckmann E, Stoehr G, Schall K, Tosi A, Schwarz M, Buchfellner A, Korber P, Hopfner KP. | 10/5/2019 |
| Binding of INO80 to these genes is cell cycle regulated, with a maximum binding preceding their transcription and accumulation of their mRNAs. In fact, the INO80 complex is required to fully and timely activate the transcription of these genes | The INO80 complex activates the transcription of S-phase genes in a cell cycle-regulated manner.
Knezevic I, González-Medina A, Gaspa L, Hidalgo E, Ayté J. | 06/8/2019 |
| we report that Isw2 and Ino80 promote efficient firing of the ribosomal origin of replication and facilitate the regulated increase of rDNA repeat copy number. This work significantly expands our understanding of the importance of ATP-dependent chromatin remodeling for rDNA biology. | Chromatin Remodeling Factors Isw2 and Ino80 Regulate Chromatin, Replication, and Copy Number of the Saccharomyces cerevisiae Ribosomal DNA Locus.
Cutler S, Lee LJ, Tsukiyama T., Free PMC Article | 03/2/2019 |
| indicate that INO80 is a highly processive remodeling motor that is tightly regulated by both substrate cues and non-catalytic subunits | The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding.
Zhou CY, Johnson SL, Lee LJ, Longhurst AD, Beckwith SL, Johnson MJ, Morrison AJ, Narlikar GJ., Free PMC Article | 01/5/2019 |
| INO80 translocates along DNA at the H2A-H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A-H2B. The data suggest that INO80 has a mechanism for dimer exchange that is distinct from other chromatin remodellers including its paralogue SWR1. | INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers.
Brahma S, Udugama MI, Kim J, Hada A, Bhardwaj SK, Hailu SG, Lee TH, Bartholomew B., Free PMC Article | 11/24/2018 |
| The INO80 complex is a central component of metabolic homeostasis that influences histone acetylation and may contribute to disease when disrupted. | The INO80 chromatin remodeler sustains metabolic stability by promoting TOR signaling and regulating histone acetylation.
Beckwith SL, Schwartz EK, García-Nieto PE, King DA, Gowans GJ, Wong KM, Eckley TL, Paraschuk AP, Peltan EL, Lee LR, Yao W, Morrison AJ., Free PMC Article | 07/21/2018 |
| results demonstrate the chaperone-like potential of Rvb1/Rvb2 and suggest a model where binding of multiple clients such as Ino80 stimulates ATP-driven cycling between hexamers and dodecamers, providing iterative opportunities for correct subunit assembly. | Regulation of Rvb1/Rvb2 by a Domain within the INO80 Chromatin Remodeling Complex Implicates the Yeast Rvbs as Protein Assembly Chaperones.
Zhou CY, Stoddard CI, Johnston JB, Trnka MJ, Echeverria I, Palovcak E, Sali A, Burlingame AL, Cheng Y, Narlikar GJ., Free PMC Article | 03/10/2018 |
| Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in S. cerevisiae. | Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals.
Xue Y, Pradhan SK, Sun F, Chronis C, Tran N, Su T, Van C, Vashisht A, Wohlschlegel J, Peterson CL, Timmers HTM, Kurdistani SK, Carey MF., Free PMC Article | 09/30/2017 |
| Arp5Delta, Ies6Delta, and INO80Delta mutants demonstrate decreased expression of genes involved in glycolysis and increased expression of genes in the oxidative phosphorylation pathway. | The INO80 Complex Requires the Arp5-Ies6 Subcomplex for Chromatin Remodeling and Metabolic Regulation.
Yao W, King DA, Beckwith SL, Gowans GJ, Yen K, Zhou C, Morrison AJ., Free PMC Article | 07/30/2016 |
| Results identify INO80 as a bona fide component of the proteolytic pathway for RNAPII degradation and suggest that INO80 nucleosome remodeling activity promotes the dissociation of ubiquitinated Rpb1 from chromatin to protect the integrity of the genome. | INO80 Chromatin Remodeler Facilitates Release of RNA Polymerase II from Chromatin for Ubiquitin-Mediated Proteasomal Degradation.
Lafon A, Taranum S, Pietrocola F, Dingli F, Loew D, Brahma S, Bartholomew B, Papamichos-Chronakis M., Free PMC Article | 04/16/2016 |
| Arp5-Ies6 interacts with chromatin via assembly with the INO80 complex, as IES2 and INO80 deletion results in loss of Arp5-Ies6 chromatin association | Assembly of the Arp5 (Actin-related Protein) Subunit Involved in Distinct INO80 Chromatin Remodeling Activities.
Yao W, Beckwith SL, Zheng T, Young T, Dinh VT, Ranjan A, Morrison AJ., Free PMC Article | 02/20/2016 |
| INO80 can activate Rad53 kinase activity in an Ies4-phosphorylation-dependent manner in the absence of known activators such as Rad9. | Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex.
Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X., Free PMC Article | 08/22/2015 |
| Both remodelers, Ino80p and Snf2p are required to recruit RNA polymerase II and targeted histone acetylation, indicating that remodelers are recruited to the CUP1 promoter before RNA polymerase II and histone acetylases. | Co-dependent recruitment of Ino80p and Snf2p is required for yeast CUP1 activation.
Wimalarathna RN, Pan PY, Shen CH. | 04/12/2014 |
| INO80 chromatin remodeler is shown to act downstream from Mec1 to increase chromatin mobility, highlighting an additional damage-related role of this nucleosome remodeling complex | Checkpoint kinases and the INO80 nucleosome remodeling complex enhance global chromatin mobility in response to DNA damage.
Seeber A, Dion V, Gasser SM., Free PMC Article | 11/16/2013 |
| Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex | Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex.
Saravanan M, Wuerges J, Bose D, McCormack EA, Cook NJ, Zhang X, Wigley DB., Free PMC Article | 03/2/2013 |
| INO80 maintains genome stability. | The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres.
Chambers AL, Ormerod G, Durley SC, Sing TL, Brown GW, Kent NA, Downs JA., Free PMC Article | 01/26/2013 |
| these data provide a mechanism for cross talk within transcriptional co-activators Ino80p and Snf2p during INO1 activation. | INO1 induction requires chromatin remodelers Ino80p and Snf2p but not the histone acetylases.
Konarzewska P, Esposito M, Shen CH. | 04/14/2012 |
| Isw2 and Ino80 are both enriched at stalled replication forks and physically and specifically interact with a single-stranded DNA binding protein, replication protein A | ATP-dependent chromatin remodeling factors tune S phase checkpoint activity.
Au TJ, Rodriguez J, Vincent JA, Tsukiyama T., Free PMC Article | 12/24/2011 |
| INO80 moved arrays of two or three nucleosomes with 50 or 79 bp of linker DNA closer together, with a final length of approximately 30 bp of linker DNA or a repeat length of approximately 177 bp. | The INO80 ATP-dependent chromatin remodeling complex is a nucleosome spacing factor.
Udugama M, Sabri A, Bartholomew B., Free PMC Article | 03/5/2011 |
| In the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced responsiveness to transcriptional changes, suggesting that INO80 controls H2A.Z dynamics. | Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity.
Papamichos-Chronakis M, Watanabe S, Rando OJ, Peterson CL., Free PMC Article | 02/26/2011 |
| These results demonstrate a critical role of INO80 in creating DNA accessibility for the NER pathway and provide direct evidence that repair of UV lesions and perhaps most bulky adduct lesions requires chromatin reconfiguration. | INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway.
Jiang Y, Wang X, Bao S, Guo R, Johnson DG, Shen X, Li L., Free PMC Article | 11/27/2010 |
| Chromatin remodeling by INO80 in cooperation with Spt6 determines the shape of the expression profile under acute stress conditions, possibly by an elongation-dependent mechanism. | Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae.
Klopf E, Paskova L, Solé C, Mas G, Petryshyn A, Posas F, Wintersberger U, Ammerer G, Schüller C., Free PMC Article | 01/21/2010 |
| SWI/SNF and INO80 are present at the INO1 promoter and are restricted to the promoter, indicating that they directly participate in localized INO1 chromatin remodeling. | Activator-dependent recruitment of SWI/SNF and INO80 during INO1 activation.
Ford J, Odeyale O, Shen CH., Free PMC Article | 01/21/2010 |
| enriched at stalled replication forks, where it promotes the resumption of replication upon recovery from fork arrest | Ino80 chromatin remodeling complex promotes recovery of stalled replication forks.
Shimada K, Oma Y, Schleker T, Kugou K, Ohta K, Harata M, Gasser SM. | 01/21/2010 |