| Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions. | Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions.
Vesela P, Zahumensky J, Malinsky J. | 02/25/2023 |
| Eisosome protein Pil1 regulates mitochondrial morphology, mitophagy, and cell death in Saccharomyces cerevisiae. | Eisosome protein Pil1 regulates mitochondrial morphology, mitophagy, and cell death in Saccharomyces cerevisiae.
Pal A, Paripati AK, Deolal P, Chatterjee A, Prasad PR, Adla P, Sepuri NBV., Free PMC Article | 12/3/2022 |
| Plasma membrane tension regulates eisosome structure and function. | Plasma membrane tension regulates eisosome structure and function.
Appadurai D, Gay L, Moharir A, Lang MJ, Duncan MC, Schmidt O, Teis D, Vu TN, Silva M, Jorgensen EM, Babst M., Free PMC Article | 12/5/2020 |
| Combined cryo-fluorescence microscopy with electron cryo-tomography results demonstrate that in cells, the BAR protein Pil1 localizes to eisosomes of varying membrane curvature. Further analysis revealed a dense protein coat on curved eisosomes, which was not present on shallow eisosomes, indicating that while BAR domains can assemble at shallow membranes, scaffold formation is tightly coupled to curvature generation. | Correlative Microscopy of Vitreous Sections Provides Insights into BAR-Domain Organization In Situ.
Bharat TAM, Hoffmann PC, Kukulski W., Free PMC Article | 03/9/2019 |
| In cells lacking the eisosome organizer Pil1, Xrn1 does not associate with the plasma membrane and its activity is preserved till the stationary phase. Thus, properly assembled eisosome is necessary for this kind of Xrn1 regulation, which occurs in a liquid culture as well as in a differentiated colony. | mRNA decay is regulated via sequestration of the conserved 5'-3' exoribonuclease Xrn1 at eisosome in yeast.
Vaškovičová K, Awadová T, Veselá P, Balážová M, Opekarová M, Malinsky J. | 06/9/2018 |
| Data indicate that Pkc1-induced phosphorylation of the eisosome core components Pil1 and Lsp1 was not exerted directly by Pkc1, but involved signaling through the Slt2 MAPK module. | Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components.
Mascaraque V, Hernáez ML, Jiménez-Sánchez M, Hansen R, Gil C, Martín H, Cid VJ, Molina M., Free PMC Article | 08/31/2013 |
| Seg1/Sle1 controls eisosome assembly and shape, which also involves Pil1 and Lsp1 | Seg1 controls eisosome assembly and shape.
Moreira KE, Schuck S, Schrul B, Fröhlich F, Moseley JB, Walther TC, Walter P., Free PMC Article | 10/20/2012 |
| Pil1 and Lsp1 self-assemble into higher-order structures and bind preferentially to phosphoinositide-containing membranes. | Eisosome proteins assemble into a membrane scaffold.
Karotki L, Huiskonen JT, Stefan CJ, Ziółkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC., Free PMC Article | 01/28/2012 |
| Pil1, an eisosome organizer, plays an important role in the recruitment of synaptojanins and amphiphysins to facilitate receptor-mediated endocytosis in yeast | Pil1, an eisosome organizer, plays an important role in the recruitment of synaptojanins and amphiphysins to facilitate receptor-mediated endocytosis in yeast.
Murphy ER, Boxberger J, Colvin R, Lee SJ, Zahn G, Loor F, Kim K. | 12/31/2011 |
| Pil1 expression is regulated by the cell cycle, which synchronizes eisosome formation with plasma membrane growth. | Pil1 controls eisosome biogenesis.
Moreira KE, Walther TC, Aguilar PS, Walter P., Free PMC Article | 01/21/2010 |
| Data suggest that Pkh1 signaling relayed to Pil1 may help regulate endocytic events to modulate the organization of the plasma membrane. | Pkh-kinases control eisosome assembly and organization.
Walther TC, Aguilar PS, Fröhlich F, Chu F, Moreira K, Burlingame AL, Walter P., Free PMC Article | 01/21/2010 |
| Loss of Pil1 leads to clustering of eisosome remnants and redirects endocytosis and endocytic effector proteins to these clusters | Eisosomes mark static sites of endocytosis.
Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. | 01/21/2010 |