| Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae. | Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae.
Sekiguchi T, Ishii T, Funakoshi M, Kobayashi H, Furuno N. | 02/21/2024 |
| Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex. | Ivy1 is a negative regulator of Gtr-dependent TORC1 activation.
Varlakhanova NV, Tornabene BA, Ford MGJ., Free PMC Article | 12/7/2019 |
| the early-endosome recycling route and its control though the Vam6>Gtr1/Gtr2>Ltv1 pathway plays a physiological role in regulating the abundance of amino acid transporters at the cell surface | Genetic dissection of early endosomal recycling highlights a TORC1-independent role for Rag GTPases.
MacDonald C, Piper RC., Free PMC Article | 10/7/2017 |
| Amino acids stimulate TORC1 through Lst4-Lst7, a GTPase-activating protein complex for the Rag family GTPase Gtr2. | Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.
Péli-Gulli MP, Sardu A, Panchaud N, Raucci S, De Virgilio C. | 07/16/2016 |
| Npr2-Npr3-dependent GTP hydrolysis of Gtr1 and direct binding of Gtr2 to Kog1, are involved in TORC1 inactivation and autophagic induction | Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy.
Kira S, Tabata K, Shirahama-Noda K, Nozoe A, Yoshimori T, Noda T., Free PMC Article | 07/25/2015 |
| Data indicate that the metabolic input acts independently of small GTPases Gtr1 and Gtr2/Rag in TOR complex 1 (TORC1) activation. | Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
Stracka D, Jozefczuk S, Rudroff F, Sauer U, Hall MN., Free PMC Article | 01/31/2015 |
| Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion. | Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion.
Jeong JH, Lee KH, Kim YM, Kim DH, Oh BH, Kim YG., Free PMC Article | 11/24/2012 |
| Data present the crystal structure of the Gtr1p-Gtr2p complex, the Rag homologs from Saccharomyces cerevisiae, at 2.8 A resolution. | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y., Free PMC Article | 12/10/2011 |
| Results describe the action of small-molecule inhibitors of exocytosis and show that Gtr2 efficiently suppresses the toxic effects of the compounds. | A chemical genetic screen for modulators of exocytic transport identifies inhibitors of a transport mechanism linked to GTR2 function.
Zhang L, Huang M, Harsay E., Free PMC Article | 04/19/2010 |
| Findings indicate that the formation of heterodimers by Gtr1p differs between Gtr2p and Ego1p. | Gtr1p differentially associates with Gtr2p and Ego1p.
Wang Y, Kurihara Y, Sato T, Toh H, Kobayashi H, Sekiguchi T. | 01/21/2010 |
| Thus, the Gtr1p-Gtr2p cycle was suggested to regulate the Ran cycle through Yrb2p. | Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p.
Wang Y, Nakashima N, Sekiguchi T, Nishimoto T. | 01/21/2010 |
| Gtr2 and the EGO fungal proteins (Ego1 and Ego3) complexes orchestrate microautophagy in yeasts. | The TOR and EGO protein complexes orchestrate microautophagy in yeast.
Dubouloz F, Deloche O, Wanke V, Cameroni E, De Virgilio C. | 01/21/2010 |