| Our results define the roles of Pat1, Lsm1, and Dhh1 in decapping of general mRNAs and suggest that these factors may monitor mRNA translation and target unique features of individual mRNAs. | General decapping activators target different subsets of inefficiently translated mRNAs.
He F, Celik A, Wu C, Jacobson A., Free PMC Article | 03/30/2019 |
| Study observations indicate that Saccharomyces cerevisiae Pat1 and Lsm1 are important for dampening ribosome transit in the 5'-UTR, and thus translation initiation of osmostress mRNAs, in particular under low stress conditions. | The Lsm1-7/Pat1 complex binds to stress-activated mRNAs and modulates the response to hyperosmotic shock.
Garre E, Pelechano V, Sánchez Del Pino M, Alepuz P, Sunnerhagen P., Free PMC Article | 01/19/2019 |
| P-bodies like LSM1 form in response to stress and act as sites of mRNA storage and degradation. Here the authors identify the mRNA targets of P-bodies during DNA replication stress, and show that P-body proteins act to prevent toxic accumulation of these target transcripts. | P-body proteins regulate transcriptional rewiring to promote DNA replication stress resistance.
Loll-Krippleber R, Brown GW., Free PMC Article | 01/13/2018 |
| the studies presented here identify a set of residues at the very C-terminal end of Lsm1 to be functionally important and suggest that these residues support the function of the Lsm1-7-Pat1 complex by facilitating RNA binding either directly or indirectly | Mutagenic Analysis of the C-Terminal Extension of Lsm1.
Chowdhury A, Kalurupalle S, Tharun S., Free PMC Article | 07/29/2017 |
| The middle domain of Pat1 is essential for the interaction of Pat1 with the Lsm1-7 complex in vivo. | Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.
Chowdhury A, Kalurupalle S, Tharun S., Free PMC Article | 10/25/2014 |
| LSm1, Pat1, and Dhh1 control the RNA3/RNA1 ratio of Flock House virus RNAs. | The cellular decapping activators LSm1, Pat1, and Dhh1 control the ratio of subgenomic to genomic Flock House virus RNAs.
Giménez-Barcons M, Alves-Rodrigues I, Jungfleisch J, Van Wynsberghe PM, Ahlquist P, Díez J., Free PMC Article | 08/3/2013 |
| The authors identify histone mRNAs as substrates of the Lsm1-7-Pat1 complex in yeast, and show that abnormally high amounts of histones accumulate in lsm1Delta mutant cells. | Lsm1 promotes genomic stability by controlling histone mRNA decay.
Herrero AB, Moreno S., Free PMC Article | 07/30/2011 |
| LSM1 over-expression in the yeast Saccharomyces cerevisiae inhibits growth primarily due to U6 snRNA depletion, thereby altering pre-mRNA splicing. | LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels.
Luhtala N, Parker R., Free PMC Article | 01/21/2010 |
| Results describe a range of mutant and hybrid Lsm1 and Lsm8 proteins, shedding light on the relative importance of their various domains in determining their localization and ability to support growth. | Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.
Reijns MA, Auchynnikava T, Beggs JD., Free PMC Article | 01/21/2010 |
| Lsmlp may confer protection against UV-radiation damage by protecting the 3' ends of mRNAs from exosome-dependent 3' to 5' degradation as part of a novel RAD5-mediated, PCNA-K164 ubiquitylation-independent subpathway of PRR. | A role for Lsmlp in response to ultraviolet-radiation damage in Saccharomyces cerevisiae.
Spicakova T, McCann K, Brown JM., Free PMC Article | 01/21/2010 |
| The Lsm1p-7p-Pat1p complex protects mRNAs by binding at/near the 3'end and distinguishes between oligoadenyLated and polyadenylated RNA. | The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs.
Chowdhury A, Mukhopadhyay J, Tharun S., Free PMC Article | 01/21/2010 |
| Mutations led to impairment of mRNA decay, did not affect the localization of the Lsm1p-7p complex. mRNA 3'-end protection could be indicative of the binding of the Lsm1p-7p complex to the mRNA. | Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.
Tharun S, Muhlrad D, Chowdhury A, Parker R., Free PMC Article | 01/21/2010 |