| Long Noncoding RNA RP11-89K21.1 Interacts with miR-146a/b-5p to Promote Proliferation and Gefitinib Resistance Through Regulating RHPN2 and RhoA/ROCK Pathway in Lung Adenocarcinoma. | Long Noncoding RNA RP11-89K21.1 Interacts with miR-146a/b-5p to Promote Proliferation and Gefitinib Resistance Through Regulating RHPN2 and RhoA/ROCK Pathway in Lung Adenocarcinoma.
Chen H, Shen D, Zhu F, Ou Q, Cheng L, Zhu Y. | 06/9/2023 |
| [RHPN2 is highly expressed in osteosarcoma cells to promote cell proliferation and migration and inhibit apoptosis]. | [RHPN2 is highly expressed in osteosarcoma cells to promote cell proliferation and migration and inhibit apoptosis].
Liu Z, Fang F, Li J, Zhao G, Zang Q, Zhang F, Die J., Free PMC Article | 10/15/2022 |
| P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin beta1/NF-kappaB pathway. | P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway.
Yan L, He Z, Li W, Liu N, Gao S., Free PMC Article | 03/26/2022 |
| The hBMSCs-derived exosomal miR-205 retards prostate cancer progression by inhibiting RHPN2, suggesting that miR-205 may present a predictor and potential therapeutic target for prostate cancer. | Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of RHPN2.
Jiang S, Mo C, Guo S, Zhuang J, Huang B, Mao X., Free PMC Article | 05/16/2020 |
| It may contribute to the pathogenesis of nonsyndromic orofacial clefts in Chinese populations. | Genetic variants of MGMT, RHPN2, and FAM49A contributed to susceptibility of nonsyndromic orofacial clefts in a Chinese population.
Chen C, Guo Q, Shi J, Jiao X, Lv K, Liu X, Jiang Y, Hui X, Song T. | 03/16/2019 |
| We found significant association between RHPN2 gene rs10411210 and colorectal cancer in European and Asian populations, but not American population | Analyzing large-scale samples highlights significant association between rs10411210 polymorphism and colorectal cancer.
He D, Ma L, Feng R, Zhang L, Jiang Y, Zhang Y, Liu G. | 06/11/2016 |
| Single nucleotide polymorphism in RHPN2 gene is associated with colorectal cancer. | Association between GWAS-identified genetic variations and disease prognosis for patients with colorectal cancer.
Kang BW, Jeon HS, Chae YS, Lee SJ, Park JY, Choi JE, Park JS, Choi GS, Kim JG., Free PMC Article | 02/27/2016 |
| These effects were implemented through RHPN2-mediated activation of RhoA. | RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.
Danussi C, Akavia UD, Niola F, Jovic A, Lasorella A, Pe'er D, Iavarone A., Free PMC Article | 02/22/2014 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype.
Abulí A, Bessa X, González JR, Ruiz-Ponte C, Cáceres A, Muñoz J, Gonzalo V, Balaguer F, Fernández-Rozadilla C, González D, de Castro L, Clofent J, Bujanda L, Cubiella J, Reñé JM, Morillas JD, Lanas A, Rigau J, García AM, Latorre M, Saló J, Fernández Bañares F, Argüello L, Peña E, Vilella A, Riestra S, Carreño R, Paya A, Alenda C, Xicola RM, Doyle BJ, Jover R, Llor X, Carracedo A, Castells A, Castellví-Bel S, Andreu M, Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGeneralizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
He J, Wilkens LR, Stram DO, Kolonel LN, Henderson BE, Wu AH, Le Marchand L, Haiman CA. Genetic heterogeneity in colorectal cancer associations between African and European americans.
Kupfer SS, Anderson JR, Hooker S, Skol A, Kittles RA, Keku TO, Sandler RS, Ellis NA. Association studies on 11 published colorectal cancer risk loci.
von Holst S, Picelli S, Edler D, Lenander C, Dalén J, Hjern F, Lundqvist N, Lindforss U, Påhlman L, Smedh K, Törnqvist A, Holm J, Janson M, Andersson M, Ekelund S, Olsson L, Ghazi S, Papadogiannakis N, Tenesa A, Farrington SM, Campbell H, Dunlop MG, Lindblom A. Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population.
Xiong F, Wu C, Bi X, Yu D, Huang L, Xu J, Zhang T, Zhai K, Chang J, Tan W, Cai J, Lin D. | 09/15/2010 |
| Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | Low-penetrance susceptibility variants in familial colorectal cancer.
Niittymäki I, Kaasinen E, Tuupanen S, Karhu A, Järvinen H, Mecklin JP, Tomlinson IP, Di Bernardo MC, Houlston RS, Aaltonen LA., Free PMC Article | 06/30/2010 |
| Observational study of genetic testing. (HuGE Navigator) | The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
Hawken SJ, Greenwood CM, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J., Free PMC Article | 06/30/2010 |
| Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) | Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
COGENT Study, Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S, Colorectal Cancer Association Study Consortium, Carvajal-Carmona L, Howarth K, Jaeger E, Spain SL, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira AS, CoRGI Consortium, Kerr D, Cazier JB, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Cetnarskyj R, Porteous ME, Pharoah PD, Koessler T, Hampe J, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, Zanke BW, Montpetit A, Hudson TJ, Gallinger S, Campbell H, Dunlop MG., Free PMC Article | 11/26/2008 |
| may play a key role between RhoB and potential downstream elements needed under stimulation of the thyrotropin/cAMP pathway in thyrocytes | Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP.
Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I. | 01/21/2010 |
| Rhophilin-2 may function normally in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity | The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.
Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD. | 01/21/2010 |