| Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase zeta complex. | Bypass of DNA interstrand crosslinks by a Rev1-DNA polymerase ζ complex.
Bezalel-Buch R, Cheun YK, Roy U, Schärer OD, Burgers PM., Free PMC Article | 10/24/2020 |
| Structure-guided mutagenesis highlights the importance of UBM2 for REV1-mediated mutagenesis and DNA damage tolerance. | Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.
Cui G, Botuyan MV, Mer G., Free PMC Article | 06/22/2019 |
| The structures of the translesion DNA synthesis polymerase Rev1 in complex with benzo[a]pyrene guanine adducts gives insights how Rev1 achieves error-free replication. | Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.
Rechkoblit O, Kolbanovskiy A, Landes H, Geacintov NE, Aggarwal AK., Free PMC Article | 03/3/2018 |
| TLS polymerase REV1 carries out DNA lesion bypass only after the Def1-assisted removal of Pol3 from the stalled replication fork. | Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage--induced mutagenesis in Saccharomyces cerevisiae.
Daraba A, Gali VK, Halmai M, Haracska L, Unk I., Free PMC Article | 08/23/2014 |
| Rev1-BRCT domain bound to PCNA can be displaced by increasing amounts of the PIP-box peptide. | NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain.
Pustovalova Y, Maciejewski MW, Korzhnev DM. | 02/22/2014 |
| Rev1 stably interacts with Rad5 via the C-terminal region of Rev1 and the N-terminal region of Rad5. | A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.
Kuang L, Kou H, Xie Z, Zhou Y, Feng X, Wang L, Wang Z. | 06/22/2013 |
| The study reports the X-ray crystal structure of the yeast Rev1 BRCT domain and show that substitutions in residues constituting its phosphate-binding pocket do not affect mutagenic translesion synthesis. | Structure and functional analysis of the BRCT domain of translesion synthesis DNA polymerase Rev1.
Pryor JM, Gakhar L, Washington MT., Free PMC Article | 03/9/2013 |
| the levels of Rev1 protein are dependent on proteasome-mediated degradation;proteasomal degradation acts as a regulatory system of mutagenic translesion DNA synthesis mediated by Rev1. | Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1.
Wiltrout ME, Walker GC., Free PMC Article | 05/7/2011 |
| results show that Rev1's catalytic activity is important in vivo when the cell has to cope with specific DNA lesions, such as N(2)-dG. | The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.
Wiltrout ME, Walker GC., Free PMC Article | 04/23/2011 |
| We present here the structure of yeast Rev1 in ternary complex with DNA containing an abasic lesion and with dCTP as the incoming nucleotide. The structure shows a mechanism of synthesis across an abasic lesion that differs from that in other polymerases. | DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase.
Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK., Free PMC Article | 03/19/2011 |
| Only the second ubiquitin-binding motif of Saccharomyces cerevisiae Rev1 binds to ubiquitin and is essential for Rev1-dependent cell survival and mutagenesis. | Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1.
Bomar MG, D'Souza S, Bienko M, Dikic I, Walker GC, Zhou P., Free PMC Article | 04/12/2010 |
| Dbf4 and Rev1 BRCT domains interact with a common protein or structure, although the precise function of both domains and their binding partners remains elusive | Budding yeast Dbf4 sequences required for Cdc7 kinase activation and identification of a functional relationship between the Dbf4 and Rev1 BRCT domains.
Harkins V, Gabrielse C, Haste L, Weinreich M., Free PMC Article | 02/22/2010 |
| Results suggest that the proto-oncogene homologue Sch9 promotes the accumulation of superoxide-dependent DNA damage in nondividing cells by a superoxide and Rev1/Polzeta-dependent mechanism. | Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism.
Madia F, Wei M, Yuan V, Hu J, Gattazzo C, Pham P, Goodman MF, Longo VD., Free PMC Article | 01/21/2010 |
| We further show that the minimal C-terminal fragment of Rev1 containing these highly conserved motifs is sufficient to interact with Rev7. | Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance.
D'Souza S, Waters LS, Walker GC., Free PMC Article | 01/21/2010 |
| Rev1 may be involved in facilitating mutagenic and recombinagenic responses to the failure of Pol delta. | Mutagenic and recombinagenic responses to defective DNA polymerase delta are facilitated by the Rev1 protein in pol3-t mutants of Saccharomyces cerevisiae.
Mito E, Mokhnatkin JV, Steele MC, Buettner VL, Sommer SS, Manthey GM, Bailis AM., Free PMC Article | 01/21/2010 |
| plays a role in mutagenesis and translesin DNA synthesis. (review) | [Induced mutagenesis and translesion DNA synthesis--structure and function of REV1].
Masuda Y, Kamiya K. | 01/21/2010 |
| Dot1 inhibits translesion synthesis (TLS) by Polzeta/Rev1 and that the methyl methanesulfonate resistance observed in the dot1 mutant results from the enhanced TLS activity. | Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.
Conde F, San-Segundo PA., Free PMC Article | 01/21/2010 |
| pre-steady-state kinetic studies with Rev1p | Pre-steady-state kinetic studies of protein-template-directed nucleotide incorporation by the yeast Rev1 protein.
Howell CA, Prakash S, Washington MT. | 01/21/2010 |
| Although in yeast a stable Rev1-Pol eta complex can be formed, this complex formation involves the polymerase-associated domain of Rev1 and not the Rev1 C terminus as in humans. | Complex formation of yeast Rev1 with DNA polymerase eta.
Acharya N, Haracska L, Prakash S, Prakash L., Free PMC Article | 01/21/2010 |
| REVIEW: REV1 is involved in somatic hypermutation and double strand break repair | Cellular functions of DNA polymerase zeta and Rev1 protein.
Lawrence CW. | 01/21/2010 |
| Results report that elevated levels of the yeast Rev1 C terminus confer a strong dominant-negative effect on viability and induced mutagenesis after DNA damage. | Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.
D'Souza S, Walker GC., Free PMC Article | 01/21/2010 |
| The polymerase domain of REV1 is responsible for the dCMP incorporation; the BRCT domain is important but dispensable for translation synthesis. | Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo.
Otsuka C, Kunitomi N, Iwai S, Loakes D, Negishi K. | 01/21/2010 |
| Strains deficient in REV1 protein show little bypass of the T-T (6-4) photoadduct or the abasic sites. | The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer.
Gibbs PE, McDonald J, Woodgate R, Lawrence CW., Free PMC Article | 01/21/2010 |
| crystal structure of Rev1 bound to template G and incoming 2'-deoxycytidine 5'-triphosphate (dCTP), which reveals that the polymerase itself dictates the identity of the incoming nucleotide, as well as the identity of the templating base | Rev1 employs a novel mechanism of DNA synthesis using a protein template.
Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. | 01/21/2010 |
| Data show that Saccharomyces cerevisiae Rev1 is subject to pronounced cell cycle control in which the levels of Rev1 protein are approximately 50-fold higher in G(2) and throughout mitosis than during G(1) and much of S phase. | The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.
Waters LS, Walker GC., Free PMC Article | 01/21/2010 |