| Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae. | Involvement of Gtr1p in the oxidative stress response in yeast Saccharomyces cerevisiae.
Sekiguchi T, Ishii T, Kamada Y, Funakoshi M, Kobayashi H, Furuno N. | 03/19/2022 |
| Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex. | Ivy1 is a negative regulator of Gtr-dependent TORC1 activation.
Varlakhanova NV, Tornabene BA, Ford MGJ., Free PMC Article | 12/7/2019 |
| the early-endosome recycling route and its control though the Vam6>Gtr1/Gtr2>Ltv1 pathway plays a physiological role in regulating the abundance of amino acid transporters at the cell surface | Genetic dissection of early endosomal recycling highlights a TORC1-independent role for Rag GTPases.
MacDonald C, Piper RC., Free PMC Article | 10/7/2017 |
| Data indicate that the metabolic input acts independently of small GTPases Gtr1 and Gtr2/Rag in TOR complex 1 (TORC1) activation. | Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
Stracka D, Jozefczuk S, Rudroff F, Sauer U, Hall MN., Free PMC Article | 01/31/2015 |
| Study demonstrates V-ATPase interacts with two distinct GTPases, Arf1 and Gtr1, which are required for Ras and TORC1 activation, respectively. | Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras/PKA and TORC1 activity.
Dechant R, Saad S, Ibáñez AJ, Peter M. | 10/18/2014 |
| The altered GTPase activity of gtr1 protein was shown associated conformational changes as compared to the wild type protein and the cysteine-less mutant. | The intrinsic GTPase activity of the Gtr1 protein from Saccharomyces cerevisiae.
Sengottaiyan P, Spetea C, Lagerstedt JO, Samyn D, Andersson M, Ruiz-Pavón L, Persson BL., Free PMC Article | 01/26/2013 |
| Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion. | Crystal structure of the Gtr1p(GTP)-Gtr2p(GDP) protein complex reveals large structural rearrangements triggered by GTP-to-GDP conversion.
Jeong JH, Lee KH, Kim YM, Kim DH, Oh BH, Kim YG., Free PMC Article | 11/24/2012 |
| Data present the crystal structure of the Gtr1p-Gtr2p complex, the Rag homologs from Saccharomyces cerevisiae, at 2.8 A resolution. | Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation.
Gong R, Li L, Liu Y, Wang P, Yang H, Wang L, Cheng J, Guan KL, Xu Y., Free PMC Article | 12/10/2011 |
| Vam6 controls TORC1(Tco89) function by activating the Gtr1 subunit of the EGO complex. | The Vam6 GEF controls TORC1 by activating the EGO complex.
Binda M, Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R, De Virgilio C. | 01/21/2010 |
| Findings indicate that the formation of heterodimers by Gtr1p differs between Gtr2p and Ego1p. | Gtr1p differentially associates with Gtr2p and Ego1p.
Wang Y, Kurihara Y, Sato T, Toh H, Kobayashi H, Sekiguchi T. | 01/21/2010 |
| We propose that Gtr1p and Gtr2p are involved in epigenetic control of gene expression in the TOR signaling pathway. | Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae.
Sekiguchi T, Hayashi N, Wang Y, Kobayashi H. | 01/21/2010 |
| Studies of Gtr1 involvement in high-affinity phosphate uptake of derepressible Pho84 in S. cerevisiae reveal a delayed response in Pho84-mediated phosphate uptake and extracellular phosphatase activity under phosphate-limiting conditions. | Structure and function of the GTP binding protein Gtr1 and its role in phosphate transport in Saccharomyces cerevisiae.
Lagerstedt JO, Reeve I, Voss JC, Persson BL. | 01/21/2010 |
| Thus, the Gtr1p-Gtr2p cycle was suggested to regulate the Ran cycle through Yrb2p. | Saccharomyces cerevisiae GTPase complex: Gtr1p-Gtr2p regulates cell-proliferation through Saccharomyces cerevisiae Ran-binding protein, Yrb2p.
Wang Y, Nakashima N, Sekiguchi T, Nishimoto T. | 01/21/2010 |