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    PDS5 Pds5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855099, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.

    S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
    Choudhary K, Itzkovich Z, Alonso-Perez E, Bishara H, Dunn B, Sherlock G, Kupiec M., Free PMC Article

    09/17/2022
    Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.

    Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
    Bastié N, Chapard C, Dauban L, Gadal O, Beckouët F, Koszul R.

    06/25/2022
    ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.

    ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
    Wang Y, Zhai B, Tan T, Yang X, Zhang J, Song M, Tan Y, Yang X, Chu T, Zhang S, Wang S, Zhang L., Free PMC Article

    11/6/2021
    PDS5A and PDS5B in Cohesin Function and Human Disease.

    PDS5A and PDS5B in Cohesin Function and Human Disease.
    Zhang N, Coutinho LE, Pati D., Free PMC Article

    06/26/2021
    Pds5+Rec8] promotes double-strand break formation, maintains homolog bias for crossover formation and promotes S-phase progression.

    Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.
    Hong S, Joo JH, Yun H, Kleckner N, Kim KP., Free PMC Article

    06/6/2020
    the integrity of the Pds5-Scc1 interface is indispensable for the recruitment of Pds5 to cohesin, and that its abrogation results in loss of sister chromatid cohesion and cell viability.

    Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.
    Muir KW, Kschonsak M, Li Y, Metz J, Haering CH, Panne D.

    01/14/2017
    a novel role for Pds5 in Saccharomyces cerevisiae

    Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
    Tong K, Skibbens RV., Free PMC Article

    02/14/2015
    propose that Pds5 maintains cohesion, at least in part, by antagonizing the polySUMO-dependent degradation of cohesin

    Pds5 prevents the PolySUMO-dependent separation of sister chromatids.
    D'Ambrosio LM, Lavoie BD.

    09/13/2014
    Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase.

    Pds5 promotes and protects cohesin acetylation.
    Chan KL, Gligoris T, Upcher W, Kato Y, Shirahige K, Nasmyth K, Beckouët F., Free PMC Article

    11/16/2013
    Scc3 and Pds5 are cohesin maintenance factors required for cohesin ring stability or for maintaining its association with DNA.

    Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA.
    Kulemzina I, Schumacher MR, Verma V, Reiter J, Metzler J, Failla AV, Lanz C, Sreedharan VT, Rätsch G, Ivanov D., Free PMC Article

    12/22/2012
    These data suggest that Pds5 modulates the Rec8 activity to facilitate chromosome morphological changes required for homologue synapsis, DSB repair, and meiotic chromosome segregation.

    Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis.
    Jin H, Guacci V, Yu HG., Free PMC Article

    01/21/2010
    Pds5p and Top2p cooperate to promote proper chromosome segregation by a mechanism unrelated to either cohesion or catenation/decatenation

    Topoisomerase II suppresses the temperature sensitivity of Saccharomyces cerevisiae pds5 mutants, but not the defect in sister chromatid cohesion.
    Aguilar C, Davidson C, Dix M, Stead K, Zheng K, Hartman T, Guacci V.

    01/21/2010
    pds5-1 causes cell death in yeast Saccharomyces cerevisiae during early meiosis

    Mutation of the cohesin related gene PDS5 causes cell death with predominant apoptotic features in Saccharomyces cerevisiae during early meiosis.
    Ren Q, Yang H, Rosinski M, Conrad MN, Dresser ME, Guacci V, Zhang Z.

    01/21/2010
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