| The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II. | The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II.
Osman S, Mohammad E, Lidschreiber M, Stuetzer A, Bazsó FL, Maier KC, Urlaub H, Cramer P., Free PMC Article | 09/4/2021 |
| CDK8 could overcome the transcriptional and posttranscriptional alterations of the fcp1 mutant by increasing Skn7 stability, protein levels, and likely the expression of target genes. | Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast.
Aristizabal MJ, Dever K, Negri GL, Shen M, Hawe N, Benschop JJ, Holstege FCP, Krogan NJ, Sadowski I, Kobor MS., Free PMC Article | 06/13/2020 |
| While active INO1 is associated with Cdk8(-) Mediator, during INO1 transcriptional memory, Cdk8(+) Mediator recruits poised RNAPII PIC lacking the Kin28 CTD kinase. | Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory.
D'Urso A, Takahashi YH, Xiong B, Marone J, Coukos R, Randise-Hinchliff C, Wang JP, Shilatifard A, Brickner JH., Free PMC Article | 11/25/2017 |
| with Srb10 clearing mostly inactive Gcn4 molecules at the promoter that are enriched for sumoylation of the activation domain, and Pho85 clearing molecules unbound to the UAS that include both fully functional and inactive Gcn4 species. | Accumulation of a threonine biosynthetic intermediate attenuates general amino acid control by accelerating degradation of Gcn4 via Pho85 and Cdk8.
Rawal Y, Qiu H, Hinnebusch AG., Free PMC Article | 02/14/2015 |
| the detailed architecture of Cdk8 module, and suggest the Cdk8 module could positively regulate transcription by modulating Mediator conformation. | Structural flexibility and functional interaction of Mediator Cdk8 module.
Wang X, Wang J, Ding Z, Ji J, Sun Q, Cai G., Free PMC Article | 04/26/2014 |
| The function of the Mediator tail module component Med3, which is required for transcription activation, is suppressed by the kinase activity of the Cdk8 module. | Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.
Gonzalez D, Hamidi N, Del Sol R, Benschop JJ, Nancy T, Li C, Francis L, Tzouros M, Krijgsveld J, Holstege FC, Conlan RS., Free PMC Article | 04/19/2014 |
| discuss recent advances in our understanding of Cdk8 function and a possible role for Mediator as a hub for integrating transcription regulation with cell cycle progression | Emerging roles of Cdk8 in cell cycle control.
Szilagyi Z, Gustafsson CM. | 09/21/2013 |
| It was shown that Phd1 is an unstable protein whose degradation is initiated through phosphorylation by Cdk8 of the RNA polymerase II mediator subcomplex. | Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae.
Raithatha S, Su TC, Lourenco P, Goto S, Sadowski I., Free PMC Article | 03/17/2012 |
| the Ccr4-Not complex has a critical role in the mechanism of activation of Skn7 that is dependent upon the Srb10 kinase | The Ccr4-not complex regulates Skn7 through Srb10 kinase.
Lenssen E, Azzouz N, Michel A, Landrieux E, Collart MA., Free PMC Article | 01/21/2010 |
| in Srb10p derivatives, the absence of CM-1 & CM-II motifs decreases the interaction of Srb10p with its cyclin partner Srb11p and with the component Tup1p of the general co-repressor complex Tup1p-Ssn6p. | Functional motifs outside the kinase domain of yeast Srb10p. Their role in transcriptional regulation and protein-interactions with Tup1p and Srb11p.
Núñez L, González-Siso MI, Becerra M, Cerdán ME. | 01/21/2010 |
| The general stress responses of yeast genes are repressed by SRB10. | Genetic factors that regulate the attenuation of the general stress response of yeast.
Bose S, Dutko JA, Zitomer RS., Free PMC Article | 01/21/2010 |
| Hda1 partially represses roughly 30% of Tup1-repressed genes, whereas Srb10 kinase activity contributes to the repression of approximately 15% of Tup1-repressed genes. | Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae.
Green SR, Johnson AD., Free PMC Article | 01/21/2010 |