| A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20. | A Protein-Protein Interaction Analysis Suggests a Wide Range of New Functions for the p21-Activated Kinase (PAK) Ste20.
Joshua IM, Lin M, Mardjuki A, Mazzola A, Höfken T., Free PMC Article | 11/18/2023 |
| Yeast daughter cells can polarize Cdc42 before CDK activation at start. This polarization operates via a positive feedback loop mediated by the Cdc42 effector Ste20. | Cell-cycle control of cell polarity in yeast.
Moran KD, Kang H, Araujo AV, Zyla TR, Saito K, Tsygankov D, Lew DJ., Free PMC Article | 10/26/2019 |
| during filamentous growth, Ste20 stimulates V-ATPase activity, this would sustain nutrient mobilization from vacuolar stores, which is beneficial for filamentous growth. | Regulation of vacuolar H+-ATPase activity by the Cdc42 effector Ste20 in Saccharomyces cerevisiae.
Lin M, Li SC, Kane PM, Höfken T., Free PMC Article | 07/28/2012 |
| cell cycle kinases Ste20 as central mediators of the cellular response to inhibition of fatty acid synthesis. (Ste20) | Global mapping of protein phosphorylation events identifies Ste20, Sch9 and the cell-cycle regulatory kinases Cdc28/Pho85 as mediators of fatty acid starvation responses in Saccharomyces cerevisiae.
Pultz D, Bennetzen MV, Rødkær SV, Zimmermann C, Enserink JM, Andersen JS, Færgeman NJ. | 06/30/2012 |
| Nbp2p SH3 domain made contacts with the Ste20 peptide core RXXPXXP motif and the Bem1p SH3b domain made stronger contacts with residues flanking the core motif. | Distinct peptide binding specificities of Src homology 3 (SH3) protein domains can be determined by modulation of local energetics across the binding interface.
Gorelik M, Davidson AR., Free PMC Article | 06/16/2012 |
| The signaling proteins Ste5 and Ste20 have recognition sequences, or "docking" sites, for G1/S (interphase) cyclins. These docking sites bind preferentially to the cyclin Cln2, and strongly enhance Cln2-driven in vivo substrate phosphorylation. | Cyclin-specific docking motifs promote phosphorylation of yeast signaling proteins by G1/S Cdk complexes.
Bhaduri S, Pryciak PM., Free PMC Article | 03/3/2012 |
| Ste20 has an unexpected role in the modulation of mRNA decay and translation in Saccharomyces cerevisiae. Phosphorylation of Dcp2 by Ste20 is an important control point for mRNA decapping. | Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae.
Yoon JH, Choi EJ, Parker R., Free PMC Article | 07/26/2010 |
| analysis of the solution structure of a novel Cdc42 binding module of Bem1 and its interaction with Ste20 and Cdc42 | Solution structure of a novel Cdc42 binding module of Bem1 and its interaction with Ste20 and Cdc42.
Takaku T, Ogura K, Kumeta H, Yoshida N, Inagaki F., Free PMC Article | 07/26/2010 |
| An in silico predictor was built to identify Ste20p substrates on a proteome-wide basis. | A biochemical genomics screen for substrates of Ste20p kinase enables the in silico prediction of novel substrates.
Annan RB, Lee AY, Reid ID, Sayad A, Whiteway M, Hallett M, Thomas DY., Free PMC Article | 03/22/2010 |
| Results suggest that the Cdc42 effectors Ste20, Cla4, and Skm1 translocate into the nucleus, where they modulate expression of sterol uptake genes via Sut1, thereby controlling sterol homeostasis. | The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.
Lin M, Unden H, Jacquier N, Schneiter R, Just U, Höfken T., Free PMC Article | 02/15/2010 |
| Ste20p & Cla4p may function as negative modulators of sterol biosynthesis. Cla4p has negative effect on steryl ester formation. Ste20p and Cla4p may regulate cell polarity in part through the modulation of sterol homeostasis. | Modulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae.
Lin M, Grillitsch K, Daum G, Just U, Höfken T. | 01/21/2010 |
| Cla4 and Ste20 play roles in cell segregation and the degradation of Vac17. | p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.
Bartholomew CR, Hardy CF., Free PMC Article | 01/21/2010 |
| These findings highlight the important interactions among PLD1, Cdc42p and Ste20p during polarized cell growth in S. cerevisiae. | An upstream regulator and downstream target of phospholipase D1 activity during pheromone response in Saccharomyces cerevisiae.
Harkins AL, London SD, Dolan JW. | 01/21/2010 |
| to gain further insight into the mechanisms of Ste20 action in cell polarity, we screened for interactors of Ste20; among the identified proteins were Erg4, Cbr1 and Ncp1, which are all involved in sterol biosynthesis | Proteins involved in sterol synthesis interact with Ste20 and regulate cell polarity.
Tiedje C, Holland DG, Just U, Höfken T. | 01/21/2010 |
| Sec14p regulation of phosphoinositide levels affects cytokinesis at the level of the Cdc42p/Cla4p/Ste20p signaling cascade. | Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesis.
Howe AG, Fairn GD, MacDonald K, Bankaitis VA, McMaster CR., Free PMC Article | 01/21/2010 |
| An evolutionarily conserved binding site for Bem1 between the CRIB and kinase domains of Ste20 was identified. | Interaction with the SH3 domain protein Bem1 regulates signaling by the Saccharomyces cerevisiae p21-activated kinase Ste20.
Winters MJ, Pryciak PM., Free PMC Article | 01/21/2010 |
| In mitogen-activated protein kinase (MAPK) cascades of budding yeast, pheromone-induced mating signal is transmitted by interactions between the beta-subunit of a G-protein (G-beta) and the G-beta binding (GBB) domain of Ste20 kinase. | An NMR-based identification of a peptide fragment from the beta-subunit of a G-protein showing specific interactions with the GBB domain of the Ste20 kinase in budding yeast.
Bhattacharjya S, Gingras R, Xu P. | 01/21/2010 |
| the SH3b (second SH3 domain) and the CI (C-terminal flanking segment) collaborate in tethering of Ste20 to Bem1 to ensure efficient mating pheromone signaling | A novel Cdc42-interacting domain of the yeast polarity establishment protein Bem1. Implications for modulation of mating pheromone signaling.
Yamaguchi Y, Ota K, Ito T. | 01/21/2010 |