| The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent. | The increase in cell death rates in caloric restricted cells of the yeast helicase mutant rrm3 is Sir complex dependent.
Ivessa AS, Singh S., Free PMC Article | 10/30/2023 |
| Sen1 and Rrm3 ensure permissive topological conditions for replication termination. | Sen1 and Rrm3 ensure permissive topological conditions for replication termination.
Choudhary R, Niska-Blakie J, Adhil M, Liberi G, Achar YJ, Giannattasio M, Foiani M. | 08/3/2023 |
| Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae. | Helicase activities of Rad5 and Rrm3 genetically interact in the prevention of recombinogenic DNA lesions in Saccharomyces cerevisiae.
Muellner J, Schmidt KH., Free PMC Article | 04/26/2023 |
| Pif1 family helicases promote mutation avoidance during DNA replication. | Pif1 family helicases promote mutation avoidance during DNA replication.
Zhou ZX, Follonier C, Lujan SA, Burkholder AB, Zakian VA, Kunkel TA., Free PMC Article | 03/10/2023 |
| Suppression of chromosome instability by targeting a DNA helicase in budding yeast. | Suppression of chromosome instability by targeting a DNA helicase in budding yeast.
Gordon MR, Zhu J, Sun G, Li R., Free PMC Article | 12/24/2022 |
| We showed that the Pif1 and Rrm3 DNA helicases promote efficient fork convergence and completion of DNA synthesis, even in the absence of type II topoisomerase. Furthermore, Rrm3 and Pif1 are also important for termination of plasmid DNA replication in vivo. | Pif1-Family Helicases Support Fork Convergence during DNA Replication Termination in Eukaryotes.
Deegan TD, Baxter J, Ortiz Bazán MÁ, Yeeles JTP, Labib KPM., Free PMC Article | 10/19/2019 |
| The absence of Rrm3 renders cells resistant to microtubule-destabilizing drugs. | Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae.
Chen CF, Pohl TJ, Pott S, Zakian VA., Free PMC Article | 03/16/2019 |
| It has been proposed that Rrm3 and Pif1 promote genome stability at tDNAs by displacing the stable multi-protein transcription complex and by removing R-loops. | PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes.
Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA., Free PMC Article | 11/17/2018 |
| Either Pif1 or Rrm3 redundantly stimulates strand displacement by DNA polymerase delta during lagging-strand synthesis. | Pif1-family helicases cooperatively suppress widespread replication-fork arrest at tRNA genes.
Osmundson JS, Kumar J, Yeung R, Smith DJ., Free PMC Article | 07/8/2017 |
| Rrm3 recruitment to replication-born DSBs is crucial for viability. | A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination.
Muñoz-Galván S, García-Rubio M, Ortega P, Ruiz JF, Jimeno S, Pardo B, Gómez-González B, Aguilera A., Free PMC Article | 06/24/2017 |
| RRM3 regulates epigenetic conversions in Saccharomyces cerevisiae in conjunction with Chromatin Assembly Factor I | RRM3 regulates epigenetic conversions in Saccharomyces cerevisiae in conjunction with Chromatin Assembly Factor I.
Wyse B, Oshidari R, Rowlands H, Abbasi S, Yankulov K., Free PMC Article | 05/20/2017 |
| our findings suggest a role of Rrm3, via its Orc5-binding domain, in restricting DNA synthesis that is genetically and physically separable from its established catalytic role in facilitating fork progression through replication blocks. | A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression.
Syed S, Desler C, Rasmussen LJ, Schmidt KH., Free PMC Article | 05/13/2017 |
| The initial telomere-proximal unstable chromosome is increased in mutants in telomerase subunits, Tel1, and even Rad9, with no known telomere-specific function. Defects in Tel1 and in Rrm3, a checkpoint protein kinase with a role in telomere maintenance and a DNA helicase, respectively, synergize dramatically to generate unstable chromosomes, further illustrating the consequence of replication error in the telomere. | Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.
Beyer T, Weinert T., Free PMC Article | 04/29/2017 |
| Rad53-mediated regulation of Rrm3 and Pif1 DNA helicases contributes to prevention of aberrant fork transitions under replication stress. | Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.
Rossi SE, Ajazi A, Carotenuto W, Foiani M, Giannattasio M., Free PMC Article | 07/16/2016 |
| Rrm3Delta and high concentrations of hydroxyurea suppressed replication slow zone expression in mec1-4ts cells. | Regulation of fragile sites expression in budding yeast by MEC1, RRM3 and hydroxyurea.
Hashash N, Johnson AL, Cha RS., Free PMC Article | 04/23/2011 |
| The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae. | The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.
Bairwa NK, Mohanty BK, Stamenova R, Curcio MJ, Bastia D., Free PMC Article | 03/5/2011 |
| Data show that overexpression of a cellular RNase H, which degrades RNA in an RNA:DNA hybrid, completely suppressed the increase in Ty1 multimer formation in an rrm3 mutant. | Rrm3 protects the Saccharomyces cerevisiae genome from instability at nascent sites of retrotransposition.
Stamenova R, Maxwell PH, Kenny AE, Curcio MJ., Free PMC Article | 01/21/2010 |
| Pif1p acts as a DNA helicase in mitochondria affects mtDNA replication directly and independently of the DNA helicase Rrm3p | Loss of mitochondrial DNA under genotoxic stress conditions in the absence of the yeast DNA helicase Pif1p occurs independently of the DNA helicase Rrm3p.
Cheng X, Qin Y, Ivessa AS. | 01/21/2010 |
| Rrm3 helicase facilitates replication through the transcription-dependent replication fork pause site and reduces recombination. | Impairment of replication fork progression mediates RNA polII transcription-associated recombination.
Prado F, Aguilera A., Free PMC Article | 01/21/2010 |
| Results show that deletion of the RRM3 gene significantly rescues the petite-induction phenotype of a Pif1p mutation and define a novel role for Rrm3p in mitochondrial function. | Differential involvement of the related DNA helicases Pif1p and Rrm3p in mtDNA point mutagenesis and stability.
O'Rourke TW, Doudican NA, Zhang H, Eaton JS, Doetsch PW, Shadel GS. | 01/21/2010 |
| Tof1p-Csm3p function differently from MRC1 and their complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae | The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.
Mohanty BK, Bairwa NK, Bastia D., Free PMC Article | 01/21/2010 |
| Replication of all yeast chromosomes was markedly delayed in rrm3 cells. | The S. cerevisiae Rrm3p DNA helicase moves with the replication fork and affects replication of all yeast chromosomes.
Azvolinsky A, Dunaway S, Torres JZ, Bessler JB, Zakian VA., Free PMC Article | 01/21/2010 |