| Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site. | Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
Shioi T, Hatazawa S, Oya E, Hosoya N, Kobayashi W, Ogasawara M, Kobayashi T, Takizawa Y, Kurumizaka H., Free PMC Article | 04/6/2024 |
| Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes. | Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes.
Deveryshetty J, Chadda R, Mattice JR, Karunakaran S, Rau MJ, Basore K, Pokhrel N, Englander N, Fitzpatrick JAJ, Bothner B, Antony E., Free PMC Article | 11/1/2023 |
| Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO. | Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO.
Antoniuk-Majchrzak J, Enkhbaatar T, Długajczyk A, Kaminska J, Skoneczny M, Klionsky DJ, Skoneczna A. | 08/19/2023 |
| Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase delta in Rad52-mediated direct-repeat recombination. | Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination.
Cerqueira PG, Meyer D, Zhang L, Mallory B, Liu J, Hua Fu BX, Zhang X, Heyer WD., Free PMC Article | 06/28/2023 |
| Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases. | Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases.
Liu G, Li J, He B, Yan J, Zhao J, Wang X, Zhao X, Xu J, Wu Y, Zhang S, Gan X, Zhou C, Li X, Zhang X, Chen X., Free PMC Article | 06/12/2023 |
| Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps. | Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
Maloisel L, Ma E, Phipps J, Deshayes A, Mattarocci S, Marcand S, Dubrana K, Coïc E., Free PMC Article | 02/24/2023 |
| Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase. | Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase.
Ziesel A, Weng Q, Ahuja JS, Bhattacharya A, Dutta R, Cheng E, Börner GV, Lichten M, Hollingsworth NM., Free PMC Article | 02/4/2023 |
| Repair of mismatched templates during Rad51-dependent Break-Induced Replication. | Repair of mismatched templates during Rad51-dependent Break-Induced Replication.
Choi J, Kong M, Gallagher DN, Li K, Bronk G, Cao Y, Greene EC, Haber JE., Free PMC Article | 10/1/2022 |
| Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis. | Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.
Woo TT, Chuang CN, Wang TF., Free PMC Article | 09/4/2021 |
| Single-Stranded DNA Curtains for Single-Molecule Visualization of Rad51-ssDNA Filament Dynamics. | Single-Stranded DNA Curtains for Single-Molecule Visualization of Rad51-ssDNA Filament Dynamics.
Roy U, Greene EC. | 06/19/2021 |
| Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association. | Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association.
Whalen JM, Dhingra N, Wei L, Zhao X, Freudenreich CH., Free PMC Article | 05/22/2021 |
| Rad54 and Rdh54 occupy spatially and functionally distinct sites within the Rad51-ssDNA presynaptic complex. | Rad54 and Rdh54 occupy spatially and functionally distinct sites within the Rad51-ssDNA presynaptic complex.
Crickard JB, Kwon Y, Sung P, Greene EC., Free PMC Article | 04/17/2021 |
| The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination. | The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Roy U, Kwon Y, Marie L, Symington L, Sung P, Lisby M, Greene EC., Free PMC Article | 03/20/2021 |
| Emerging non-canonical roles for the Rad51-Rad52 interaction in response to double-strand breaks in yeast. | Emerging non-canonical roles for the Rad51-Rad52 interaction in response to double-strand breaks in yeast.
Ngo K, Epum EA, Friedman KL., Free PMC Article | 02/27/2021 |
| Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae. | Effect of BRCA1 missense variants on gene reversion in DNA double-strand break repair mutants and cell cycle-arrested cells of Saccharomyces cerevisiae.
Lodovichi S, Bellè F, Cervelli T, Lorenzoni A, Maresca L, Cozzani C, Caligo MA, Galli A. | 01/2/2021 |
| Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks. | Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks.
Woo TT, Chuang CN, Higashide M, Shinohara A, Wang TF., Free PMC Article | 10/24/2020 |
| Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase. | Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase.
Lan WH, Lin SY, Kao CY, Chang WH, Yeh HY, Chang HY, Chi P, Li HW., Free PMC Article | 08/29/2020 |
| In S. cerevisiae telomere addition is significantly reduced in the absence of the Rad51 recombinase, while loss of Rad52, required for Rad51 nucleoprotein filament formation, has no effect. Deletion of RAD52 suppresses the defect of the rad51Delta strain, suggesting that Rad52 inhibits de novo telomere addition in the absence of Rad51. | Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition.
Epum EA, Mohan MJ, Ruppe NP, Friedman KL., Free PMC Article | 05/16/2020 |
| Data suggest that recombinase RAD51 (Rad51)/DNA-dependent ATPase RAD54 (Rad54) form a functional unit operating in homology search, synaptic complex and D-loop formation. | In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation.
Tavares EM, Wright WD, Heyer WD, Le Cam E, Dupaigne P., Free PMC Article | 01/4/2020 |
| we find that Sgs1 utilizes a novel motor mechanism for disrupting ssDNA intermediates bound by the recombinase protein Rad51. The ability of Sgs1 to disrupt Rad51-ssDNA filaments may explain some of the defects engendered by RECQ helicase deficiencies in human cells | The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments.
Crickard JB, Xue C, Wang W, Kwon Y, Sung P, Greene EC., Free PMC Article | 11/30/2019 |
| Lack of SOD1 in a RAD51 mutant depending on CCS1 exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae. | Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress-mediated cytotoxicity in Saccharomyces cerevisiae.
Choi JE, Heo SH, Kim MJ, Chung WH. | 10/5/2019 |
| Rad52-RFP and Rad51-GFP co-localize to the same DSB, but a significant minority of foci have Rad51-GFP without visible Rad52-RFP. We conclude that co-localization of foci in cells with 3 DSBs does not represent formation of a homologous recombination "repair center," as the same distribution of Ddc2-GFP foci was found in the absence of the Rad52 protein. | Live cell monitoring of double strand breaks in S. cerevisiae.
Waterman DP, Zhou F, Li K, Lee CS, Tsabar M, Eapen VV, Mazzella A, Haber JE., Free PMC Article | 03/30/2019 |
| propose that Rad51 and Dmc1 have intrinsic capacities to form spatially distinct filaments, suggesting that additional recombination cofactors are not required to segregate the Rad51 and Dmc1 filaments | Spontaneous self-segregation of Rad51 and Dmc1 DNA recombinases within mixed recombinase filaments.
Crickard JB, Kaniecki K, Kwon Y, Sung P, Greene EC., Free PMC Article | 01/12/2019 |
| Global chromosome mobility is regulated by the Rad51 recombinase and its mediator, Rad52. | Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint.
Smith MJ, Bryant EE, Rothstein R., Free PMC Article | 10/6/2018 |
| Srs2 rapidly disrupts small heteroduplex DNA joints bound to Rad51 filaments. | Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2.
Kaniecki K, De Tullio L, Gibb B, Kwon Y, Sung P, Greene EC., Free PMC Article | 07/28/2018 |