| Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair. | Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair.
Gong W, Holmberg H, Lu C, Huang M, Li S., Free PMC Article | 06/25/2024 |
| Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process. | Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent Process.
Amaral L, Mendes F, Côrte-Real M, Sousa MJ, Chaves SR., Free PMC Article | 05/22/2021 |
| The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion. | The DNA damage-sensing NER repair factor XPC-RAD23B does not recognize bulky DNA lesions with a missing nucleotide opposite the lesion.
Feher KM, Kolbanovskiy A, Durandin A, Shim Y, Min JH, Lee YC, Shafirovich V, Mu H, Broyde S, Geacintov NE., Free PMC Article | 04/3/2021 |
| Tethering-facilitated DNA 'opening' and complementary roles of beta-hairpin motifs in the Rad4/XPC DNA damage sensor protein. | Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4/XPC DNA damage sensor protein.
Paul D, Mu H, Tavakoli A, Dai Q, Chen X, Chakraborty S, He C, Ansari A, Broyde S, Min JH., Free PMC Article | 01/2/2021 |
| Sequence specificity, energetics and mechanism of mismatch recognition by DNA damage sensing protein Rad4/XPC has been reported. | Sequence specificity, energetics and mechanism of mismatch recognition by DNA damage sensing protein Rad4/XPC.
Panigrahi A, Vemuri H, Aggarwal M, Pitta K, Krishnan M., Free PMC Article | 05/23/2020 |
| Enhanced spontaneous DNA twisting/bending fluctuations promote mismatch recognition by the Rad4 nucleotide excision repair complex. | Enhanced spontaneous DNA twisting/bending fluctuations unveiled by fluorescence lifetime distributions promote mismatch recognition by the Rad4 nucleotide excision repair complex.
Chakraborty S, Steinbach PJ, Paul D, Mu H, Broyde S, Min JH, Ansari A., Free PMC Article | 07/6/2019 |
| Upon binding of RAD4 to the DNA, the global free energy minimum is shifted to the extrahelical state indicating the key role of RAD4-DNA interactions in catalyzing the dinucleotide base extrusion in the DNA-RAD4 complex. | Molecular Mechanism, Dynamics, and Energetics of Protein-Mediated Dinucleotide Flipping in a Mismatched DNA: A Computational Study of the RAD4-DNA Complex.
Pitta K, Krishnan M. | 02/23/2019 |
| Rad4-Rad23 forms non-motile complexes or conducts a one-dimensional search for DNA lesions via either random diffusion or constrained motion. | Single-Molecule Imaging Reveals that Rad4 Employs a Dynamic DNA Damage Recognition Process.
Kong M, Liu L, Chen X, Driscoll KI, Mao P, Böhm S, Kad NM, Watkins SC, Bernstein KA, Wyrick JJ, Min JH, Van Houten B., Free PMC Article | 09/9/2017 |
| Rad4 recognizes lesions in a step-wise "twist-open" mechanism, in which preliminary twisting represents Rad4 interconverting between search and interrogation modes. | Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex.
Velmurugu Y, Chen X, Slogoff Sevilla P, Min JH, Ansari A., Free PMC Article | 09/3/2016 |
| Rad4/XPC uses a kinetic gating mechanism whereby lesion selectivity arises from the kinetic competition between DNA opening and the residence time of Rad4/XPC per site. | Kinetic gating mechanism of DNA damage recognition by Rad4/XPC.
Chen X, Velmurugu Y, Zheng G, Park B, Shim Y, Kim Y, Liu L, Van Houten B, He C, Ansari A, Min JH., Free PMC Article | 12/12/2015 |
| Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae | Degradation of specific nuclear proteins occurs in the cytoplasm in Saccharomyces cerevisiae.
Chen L, Madura K., Free PMC Article | 12/27/2014 |
| A novel role of Rad4p in the regulation of heterochromatin structure and gene silencing. | Detection of an altered heterochromatin structure in the absence of the nucleotide excision repair protein Rad4 in Saccharomyces cerevisiae.
Zhang L, Chen H, Bi X, Gong F., Free PMC Article | 04/26/2014 |
| Disruption of UBP3 leads to enhanced UV resistance and elevated Rad4 stability. | Yeast deubiquitinase Ubp3 interacts with the 26 S proteasome to facilitate Rad4 degradation.
Mao P, Smerdon MJ., Free PMC Article | 01/1/2011 |
| Rad4, a Rad23-binding protein, regulates ubiquitylated substrate turnover. | Rad4 regulates protein turnover at a postubiquitylation step.
Li Y, Yan J, Kim I, Liu C, Huo K, Rao H., Free PMC Article | 03/29/2010 |
| Data show that Rad4p is essential for repair in the intergenic spacer and the transcription initiation site, while Rad34p is necessary for transcription-coupled NER that starts about 40 nucleotides downstream of the transcription initiation site. | Complementary roles of yeast Rad4p and Rad34p in nucleotide excision repair of active and inactive rRNA gene chromatin.
Tremblay M, Teng Y, Paquette M, Waters R, Conconi A., Free PMC Article | 01/21/2010 |
| crystal structure of the yeast XPC orthologue Rad4 bound to DNA containing a cyclobutane pyrimidine dimer (CPD) lesion | Recognition of DNA damage by the Rad4 nucleotide excision repair protein.
Min JH, Pavletich NP. | 01/21/2010 |
| Rad23 stabilizes Rad4 from degradation during nucleotide excision-repair. | Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway.
Ortolan TG, Chen L, Tongaonkar P, Madura K., Free PMC Article | 01/21/2010 |
| Ufd4, the E3 component of the UFD pathway, is involved in controlling the degradation of Rad4, and Ufd4 and Rad23 exhibit a synthetic inhibitory effect on Rad4 degradation | A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23.
Ju D, Xie Y. | 01/21/2010 |
| Snf6 and Snf5, two subunits of the SWI/SNF chromatin-remodeling complex in Saccharomyces cerevisiae, copurify with the NER damage-recognition heterodimer Rad4-Rad23. This interaction between SWI/SNF and Rad4-Rad23 is stimulated by UV irradiation. | Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.
Gong F, Fahy D, Smerdon MJ. | 01/21/2010 |