| CRISPR Screen Reveals PACT as a Pro-Viral Factor for Dengue Viral Replication. | CRISPR Screen Reveals PACT as a Pro-Viral Factor for Dengue Viral Replication.
Shivaprasad S, Qiao W, Weng KF, Umashankar P, Carette JE, Sarnow P., Free PMC Article | 08/15/2024 |
| PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3beta-N-nsp3 cascade. | PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3β-N-nsp3 cascade.
Lin YY, Yao R, Zhuang J, Wang B, Du L, Guo D, Pan JA, Peng X. | 06/7/2023 |
| PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation. | PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation.
Wei L, Wang W, Yao J, Cui Z, Xu Z, Ding H, Wu X, Wang D, Luo J, Ke ZJ. | 09/24/2022 |
| DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction. | DYT-PRKRA Mutation P222L Enhances PACT's Stimulatory Activity on Type I Interferon Induction.
Vaughn LS, Frederick K, Burnett SB, Sharma N, Bragg DC, Camargos S, Cardoso F, Patel RC., Free PMC Article | 06/11/2022 |
| SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules. | SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules.
Zheng Y, Deng J, Han L, Zhuang MW, Xu Y, Zhang J, Nan ML, Xiao Y, Zhan P, Liu X, Gao C, Wang PH., Free PMC Article | 02/19/2022 |
| A tale of two proteins: PACT and PKR and their roles in inflammation. | A tale of two proteins: PACT and PKR and their roles in inflammation.
Chukwurah E, Farabaugh KT, Guan BJ, Ramakrishnan P, Hatzoglou M., Free PMC Article | 12/4/2021 |
| High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1). | High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1).
Neault N, O'Reilly S, Baig AT, Plaza-Diaz J, Azimi M, Farooq F, Baird SD, MacKenzie A., Free PMC Article | 11/22/2021 |
| Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2alpha signaling leading to a compromised stress response. | Dystonia 16 (DYT16) mutations in PACT cause dysregulated PKR activation and eIF2α signaling leading to a compromised stress response.
Burnett SB, Vaughn LS, Sharma N, Kulkarni R, Patel RC. | 10/30/2021 |
| Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling. | Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling.
Vaughn LS, Chukwurah E, Patel RC., Free PMC Article | 06/19/2021 |
| A truncated PACT protein resulting from a frameshift mutation reported in movement disorder DYT16 triggers caspase activation and apoptosis. | A truncated PACT protein resulting from a frameshift mutation reported in movement disorder DYT16 triggers caspase activation and apoptosis.
Burnett SB, Vaughn LS, Strom JM, Francois A, Patel RC., Free PMC Article | 09/12/2020 |
| LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses. | LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses.
Sanchez David RY, Combredet C, Najburg V, Millot GA, Beauclair G, Schwikowski B, Léger T, Camadro JM, Jacob Y, Bellalou J, Jouvenet N, Tangy F, Komarova AV. | 08/15/2020 |
| ASPACT acts as a negative regulator of PACT at multiple levels | A novel antisense RNA ASPACT confers multi-level suppression of PACT and associated signalling.
Kuo YP, Ma CP, Chen HW, Chen YT, Lai YH, Liu H, Kuo RL, Chin-Ming Tan B., Free PMC Article | 03/21/2020 |
| Study demonstrated that PACT is frequently overexpressed in mucinous ovarian cancer (MOC) cells and regulates oxaliplatin resistance of MOC cells. | PRKRA/PACT Expression Promotes Chemoresistance of Mucinous Ovarian Cancer.
Hisamatsu T, McGuire M, Wu SY, Rupaimoole R, Pradeep S, Bayraktar E, Noh K, Hu W, Hansen JM, Lyons Y, Gharpure KM, Nagaraja AS, Mangala LS, Mitamura T, Rodriguez-Aguayo C, Eun YG, Rose J, Bartholomeusz G, Ivan C, Lee JS, Matsuo K, Frumovitz M, Wong KK, Lopez-Berestein G, Sood AK., Free PMC Article | 11/30/2019 |
| This study report the PRKRA mutation causing adulthood-onset dystonia. | The prevalence of PRKRA mutations in idiopathic dystonia.
Dos Santos CO, da Silva-Júnior FP, Puga RD, Barbosa ER, Azevedo Silva SMC, Borges V, Limongi JCP, Rocha MSG, Ferraz HB, de Carvalho Aguiar P. | 04/20/2019 |
| The antiviral activity of PACT is mediated primarily via its interaction with and inhibition of IAV polymerase. | Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase.
Chan CP, Yuen CK, Cheung PH, Fung SY, Lui PY, Chen H, Kok KH, Jin DY. | 02/16/2019 |
| Low PACT expression is associated with Arenaviral infections. | Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production.
Shao J, Huang Q, Liu X, Di D, Liang Y, Ly H., Free PMC Article | 08/4/2018 |
| phenotype of our patients overlaps that of previouslyreported DYT16 patients | PRKRA Mutation Causing Early-Onset Generalized Dystonia-Parkinsonism (DYT16) in an Italian Family.
Quadri M, Olgiati S, Sensi M, Gualandi F, Groppo E, Rispoli V, Graafland J, Breedveld GJ, Fabbrini G, Berardelli A, Bonifati V. | 02/24/2018 |
| this study shows that PACT is an essential coactivator of the MDA5-dependent type I IFN response to viral RNA | PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization.
Lui PY, Wong LR, Ho TH, Au SWN, Chan CP, Kok KH, Jin DY., Free PMC Article | 09/30/2017 |
| High PRKRA mRNA expression is associated with colorectal cancer. | Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.
Mullany LE, Herrick JS, Wolff RK, Slattery ML., Free PMC Article | 07/22/2017 |
| It was established in this report that interactions between PACT, ADAR1 and HIV-1-encoded Tat protein diminish the activation of PKR in response to HIV-1 infection. | ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element.
Chukwurah E, Handy I, Patel RC., Free PMC Article | 06/24/2017 |
| 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. | Mutational analysis of GSC, HOXA2 and PRKRA in 106 Chinese patients with microtia.
Hao S, Jin L, Li C, Wang H, Zheng F, Ma D, Zhang T. | 03/18/2017 |
| MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells. | MicroRNA-122 Inhibits the Production of Inflammatory Cytokines by Targeting the PKR Activator PACT in Human Hepatic Stellate Cells.
Nakamura M, Kanda T, Sasaki R, Haga Y, Jiang X, Wu S, Nakamoto S, Yokosuka O., Free PMC Article | 06/28/2016 |
| The interferon-induced protein kinase(PACT) partially rescued defects of interferon-beta1 and chemokine (C-C motif) ligand 5/RANTES (regulated on activation normal T cell expressed and secreted) induction in DDX3-knockdown HEK293 cells. | DDX3 functions in antiviral innate immunity through translational control of PACT.
Lai MC, Sun HS, Wang SW, Tarn WY., Free PMC Article | 06/11/2016 |
| These findings support a model in which a measles virus defective interfering RNA is sensed by PACT and RIG-I to initiate an innate antiviral response via activation of interferon-beta production. | PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine.
Ho TH, Kew C, Lui PY, Chan CP, Satoh T, Akira S, Jin DY, Kok KH., Free PMC Article | 05/28/2016 |
| this study demonstrates for the first time that OV20.0 of Orf virus is also able to interact with the dsRNA binding domain of PACT and that the presence of dsRNA strengthened the interaction of these two molecules. | Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus.
Tseng YY, Liao GR, Sen GC, Lin FY, Hsu WL., Free PMC Article | 01/30/2016 |