| Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis. | Zika Virus Induces Degradation of the Numb Protein Required through Embryonic Neurogenesis.
He J, Yang L, Chang P, Yang S, Wang Y, Lin S, Tang Q, Zhang Y., Free PMC Article | 07/7/2023 |
| Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool. | Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool.
Filippone MG, Freddi S, Zecchini S, Restelli S, Colaluca IN, Bertalot G, Pece S, Tosoni D, Di Fiore PP., Free PMC Article | 10/15/2022 |
| Notch, Numb and Numb-like responses to exercise-induced muscle damage in human skeletal muscle. | Notch, Numb and Numb-like responses to exercise-induced muscle damage in human skeletal muscle.
Bubak MP, Stout K, Tomtschik J, Peterson E, Cardozo CP, Graham ZA, Gallagher P., Free PMC Article | 08/6/2022 |
| miR-146a-5p Promotes Chondrocyte Apoptosis and Inhibits Autophagy of Osteoarthritis by Targeting NUMB. | miR-146a-5p Promotes Chondrocyte Apoptosis and Inhibits Autophagy of Osteoarthritis by Targeting NUMB.
Zhang H, Zheng W, Li D, Zheng J., Free PMC Article | 07/9/2022 |
| NUMB as a Therapeutic Target for Melanoma. | NUMB as a Therapeutic Target for Melanoma.
Hristova DM, Fukumoto T, Takemori C, Gao L, Hua X, Wang JX, Li L, Beqiri M, Watters A, Vultur A, Gimie Y, Rebecca V, Samarkina A, Jimbo H, Nishigori C, Zhang J, Cheng C, Wei Z, Somasundaram R, Fukunaga-Kalabis M, Herlyn M., Free PMC Article | 06/25/2022 |
| Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression. | Prognostic Biomarker NUMB Is Inhibited by Breast Cancer Cell Exosomes to Promote Breast Cancer Progression.
Qin X, Cao Y., Free PMC Article | 05/7/2022 |
| Numb-PRRL promotes TGF-beta1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer. | Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.
Sheng W, Tang J, Cao R, Shi X, Ma Y, Dong M., Free PMC Article | 04/16/2022 |
| Numb exon 9 inclusion regulates Integrinbeta5 surface expression and promotes breast cancer metastasis. | Numb exon 9 inclusion regulates Integrinβ5 surface expression and promotes breast cancer metastasis.
Zhang Y, Dho SE, Othman K, Simpson CD, Lapierre J, Bondoc A, McGlade CJ. | 04/9/2022 |
| Numb inhibits migration and promotes proliferation of colon cancer cells via RhoA/ROCK signaling pathway repression. | Numb inhibits migration and promotes proliferation of colon cancer cells via RhoA/ROCK signaling pathway repression.
Yang Y, Li L, He H, Shi M, He L, Liang S, Qi J, Chen W. | 02/12/2022 |
| Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling. | Loss of Numb promotes hepatic progenitor expansion and intrahepatic cholangiocarcinoma by enhancing Notch signaling.
Shu Y, Xu Q, Xu Y, Tao Q, Shao M, Cao X, Chen Y, Wu Z, Chen M, Zhou Y, Zhou P, Shi Y, Bu H., Free PMC Article | 02/5/2022 |
| The role of NUMB/NUMB isoforms in cancer stem cells. | The role of NUMB/NUMB isoforms in cancer stem cells.
Choi HY, Seok J, Kang GH, Lim KM, Cho SG., Free PMC Article | 01/1/2022 |
| miR-31-NUMB Cascade Modulates Monocarboxylate Transporters to Increase Oncogenicity and Lactate Production of Oral Carcinoma Cells. | miR-31-NUMB Cascade Modulates Monocarboxylate Transporters to Increase Oncogenicity and Lactate Production of Oral Carcinoma Cells.
Chou CH, Chiang CF, Yang CC, Liu YC, Chang SR, Chang KW, Lin SC., Free PMC Article | 12/18/2021 |
| NUMB suppression by miR-9-5P enhances CD44(+) prostate cancer stem cell growth and metastasis. | NUMB suppression by miR-9-5P enhances CD44(+) prostate cancer stem cell growth and metastasis.
Wang X, Cai J, Zhao L, Zhang D, Xu G, Hu J, Zhang T, Jin M., Free PMC Article | 11/6/2021 |
| NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain. | NUMB enhances Notch signaling by repressing ubiquitination of NOTCH1 intracellular domain.
Luo Z, Mu L, Zheng Y, Shen W, Li J, Xu L, Zhong B, Liu Y, Zhou Y., Free PMC Article | 08/14/2021 |
| Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5. | Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5.
Wang N, Wang DD, Hou X, Li X, Shen Y. | 05/22/2021 |
| Progress in the research of p53 tumour suppressor activity controlled by Numb in triple-negative breast cancer. | Progress in the research of p53 tumour suppressor activity controlled by Numb in triple-negative breast cancer.
Xian J, Cheng Y, Qin X, Cao Y, Luo Y, Cao Y., Free PMC Article | 05/1/2021 |
| Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer. | Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Wang G, Sheng W, Tang J, Li X, Zhou J, Dong M., Free PMC Article | 12/5/2020 |
| Musashi1 expression is negatively correlated with numb expression in brain metastases. | Musashi1 expression is negatively correlated with numb expression in brain metastases.
Dong Y, Li J, Liu R, Zhao Z, Wang S, Cui K., Free PMC Article | 11/21/2020 |
| Numb functions as a tumor suppressor in colorectal cancer, and its tumor suppressor function is mediated by negative regulation of the epithelial mesenchymal transition through the Wnt signaling pathway. | Numb negatively regulates the epithelial-to-mesenchymal transition in colorectal cancer through the Wnt signaling pathway.
Cheng C, Huang Z, Zhou R, An H, Cao G, Ye J, Huang C, Wu D. | 08/1/2020 |
| HMGA1 knockdown-induced NUMB upregulation. | HMGA1 negatively regulates NUMB expression at transcriptional and post transcriptional level in glioblastoma stem cells.
Puca F, Tosti N, Federico A, Kuzay Y, Pepe A, Morlando S, Savarese T, D'Alessio F, Colamaio M, Sarnataro D, Ziberi S, De Martino M, Fusco A, Battista S., Free PMC Article | 07/11/2020 |
| Knockdown of NUMB endocytic adaptor protein (Numb could promote the epithelial mesenchymal transition (EMT) of breast cancer cells via beta-catenin/RNA binding protein Lin28 (Lin28) signal pathway. | Numb confers to inhibit epithelial mesenchymal transition via β-catenin/Lin28 signaling pathway in breast cancer.
Hu XB, Ouyang LZ, He Y, Xia MZ. | 02/29/2020 |
| Data show that member RAS oncogene family protein RAB27B (RAB27B) expression is required for the secretion of colorectal cancer stem cells (CRCSCs) exosomes, and exosomal miR-146a promotes stem-like properties and tumorigenicity by targeting endocytic adaptor protein Numb (Numb) in colorectal cancer (CRC) cells. | RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
Cheng WC, Liao TT, Lin CC, Yuan LE, Lan HY, Lin HH, Teng HW, Chang HC, Lin CH, Yang CY, Huang SC, Jiang JK, Yang SH, Yang MH, Hwang WL. | 02/8/2020 |
| Numb negatively regulated Notch signaling pathway in epithelial-mesenchymal transition of diabetic nephropathy (DN), implying that they had great potentials to serve as therapeutic targets or diagnostic biomarkers for DN. | The implication of Numb-induced Notch signaling in endothelial-mesenchymal transition of diabetic nephropathy.
Liu W, Wu Y, Yu F, Hu W, Fang X, Hao W. | 10/5/2019 |
| NUMB negatively controls membrane protrusions and the acquisition of mesenchymal migratory traits by modulating EFA6B-ARF6 activity. | A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.
Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G., Free PMC Article | 09/21/2019 |
| Data show the expression of Zeb1 and Numb were both significantly higher in LLC-symmetric cell division than LLC-asymmetric cell division cells. | Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31.
Wang J, Zhou T, Sun Z, Ye T, Zhou S, Li J, Liu Y, Kong L, Tang J, Liu D, Xing HR., Free PMC Article | 09/14/2019 |