| Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway. | Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway.
Xu Y, Yang T, Xu Q, Tang Y, Yang Q. | 07/22/2024 |
| The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion. | The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion.
Jian F, Wang S, Tian R, Wang Y, Li C, Li Y, Wang S, Fang C, Ma C, Rong Y., | 02/6/2024 |
| VAMP8 suppresses the metastasis via DDX5/beta-catenin signal pathway in osteosarcoma. | VAMP8 suppresses the metastasis via DDX5/β-catenin signal pathway in osteosarcoma.
Yang S, Zhou P, Zhang L, Xie X, Zhang Y, Bo K, Xue J, Zhang W, Liao F, Xu P, Hu Y, Yan R, Liu D, Chang J, Zhou K., Free PMC Article | 07/10/2023 |
| Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8. | Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8.
Ohnishi Y, Tsuji D, Itoh K. | 11/12/2022 |
| Prefused lysosomes cluster on autophagosomes regulated by VAMP8. | Prefused lysosomes cluster on autophagosomes regulated by VAMP8.
Chen Q, Hao M, Wang L, Li L, Chen Y, Shao X, Tian Z, Pfuetzner RA, Zhong Q, Brunger AT, Guan JL, Diao J., Free PMC Article | 02/5/2022 |
| Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy. | Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy.
Xing Y, Wei X, Wang MM, Liu Y, Sui Z, Wang X, Zhang Y, Fei YH, Jiang Y, Lu C, Zhang P, Chen R, Liu N, Wu M, Ding L, Wang Y, Guo F, Cao JL, Qi J, Wang W. | 01/8/2022 |
| mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation. | mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation.
Huang H, Ouyang Q, Zhu M, Yu H, Mei K, Liu R., Free PMC Article | 12/18/2021 |
| Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway. | Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway.
Davis LJ, Bright NA, Edgar JR, Parkinson MDJ, Wartosch L, Mantell J, Peden AA, Luzio JP., Free PMC Article | 09/4/2021 |
| Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population. | Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population.
Kotarac N, Dobrijevic Z, Matijasevic S, Savic-Pavicevic D, Brajuskovic G. | 06/26/2021 |
| Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion. | Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion.
Li Y, Cheng X, Li M, Wang Y, Fu T, Zhou Z, Wang Y, Gong X, Xu X, Liu J, Pan L., Free PMC Article | 10/24/2020 |
| data show that defects in adaptor protein complex 3-dependent maturation of Weibel-Palade bodies impairs exocytosis by affecting the recruitment of VAMP8. | Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Karampini E, Schillemans M, Hofman M, van Alphen F, de Boer M, Kuijpers TW, van den Biggelaar M, Voorberg J, Bierings R., Free PMC Article | 07/11/2020 |
| these results provide evidence that TRIM6 contributes to the antiviral response against WNV and identify VAMP8 as a novel regulator of the IFN-I system. | VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection.
van Tol S, Atkins C, Bharaj P, Johnson KN, Hage A, Freiberg AN, Rajsbaum R., Free PMC Article | 06/13/2020 |
| autophagic degradation critically determines the production of HBV virions and HBsAg; this is controlled by the SNAP29-VAMP8 interaction | Synaptosomal-associated protein 29 is required for the autophagic degradation of hepatitis B virus.
Lin Y, Wu C, Wang X, Liu S, Kemper T, Li F, Squire A, Zhu Y, Zhang J, Chen X, Lu M. | 06/6/2020 |
| Findings indicate that patients with low vesicle associated membrane protein 8 (VAMP8)/low rab GTP-binding protein RAB37 (RAB37) expression profile showed significantly high risk of death even after adjusting for tumor metastasis parameter. | VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Wang YS, Tzeng HT, Tsai CH, Cheng HC, Lai WW, Liu HS, Wang YC. | 09/28/2019 |
| The rs1010 SNP genotypes AG (p = 0.028) and GG (p = 0.016) were associated with increased susceptibility to Pulmonary Tuberculosis. | Association of VAMP8 rs1010 Polymorphism with Host Susceptibility to Pulmonary Tuberculosis in a Chinese Han Population.
Cheng S, Sun C, Lao W, Kang H. | 06/8/2019 |
| our study suggested that VAMP8 gene variants might not contribute to glioma susceptibility and associated with glioma in the Chinese Han population. | No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population.
Zhou P, Zhang S, Chen H, Chen Y, Liu X, Sun B., Free PMC Article | 04/23/2016 |
| Vesicle-associated membrane protein 8 as a novel oncogene by promoting cell proliferation and therapeutic resistance in glioma. Targeting VAMP8 may serve as a potential therapeutic regimen for the treatment of glioma. | VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells.
Chen Y, Meng D, Wang H, Sun R, Wang D, Wang S, Fan J, Zhao Y, Wang J, Yang S, Huai C, Song X, Qin R, Xu T, Yun D, Hu L, Yang J, Zhang X, Chen H, Chen J, Chen H, Lu D., Free PMC Article | 03/19/2016 |
| Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. | Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
Jean S, Cox S, Nassari S, Kiger AA., Free PMC Article | 12/12/2015 |
| Cytotoxic granule exocytosis is a sequential, multivesicle fusion process requiring VAMP8-mediated recycling endosome fusion before cytotoxic granule fusion. | VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity.
Marshall MR, Pattu V, Halimani M, Maier-Peuschel M, Müller ML, Becherer U, Hong W, Hoth M, Tschernig T, Bryceson YT, Rettig J., Free PMC Article | 10/10/2015 |
| Inhibition of VAMP8, but not VAMP7, significantly reduces viral entry. | UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C., Free PMC Article | 04/19/2014 |
| VAMP8 regulates mucin granule exocytosis in airway goblet cells, and reduction of its expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases | VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells.
Jones LC, Moussa L, Fulcher ML, Zhu Y, Hudson EJ, O'Neal WK, Randell SH, Lazarowski ER, Boucher RC, Kreda SM., Free PMC Article | 06/23/2012 |
| Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. | KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ. | 05/26/2012 |
| Dynamics of FIP3- and VAMP8-containing endosomes reflect the progressive stages of abscission. | Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission.
Schiel JA, Park K, Morphew MK, Reid E, Hoenger A, Prekeris R., Free PMC Article | 09/24/2011 |
| The VAMP8 rs1010 polymorphism was associated with CHD risk in Chinese Han population, the A allele might serve as a genetic risk factor of coronary heart disease. | [Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population].
Duan CC, Xu LX, Chen Q. | 09/20/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |