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    BECN1 beclin 1 [ Homo sapiens (human) ]

    Gene ID: 8678, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of molecular signatures and molecular dynamics simulation of highly deleterious missense variants of key autophagy regulator beclin 1: a computational based approach.

    Identification of molecular signatures and molecular dynamics simulation of highly deleterious missense variants of key autophagy regulator beclin 1: a computational based approach.
    Kaur S, Vashistt J, Changotra H.

    10/28/2024
    Autophagy Gene BECN1 Intronic Variant rs9890617 Predisposes Individuals to Hepatitis B Virus Infection.

    Autophagy Gene BECN1 Intronic Variant rs9890617 Predisposes Individuals to Hepatitis B Virus Infection.
    Kaur S, Vashistt J, Changotra H.

    10/1/2024
    BECN1 mRNA expression in breast cancer tissue; significant correlation to tumor grade.

    BECN1 mRNA expression in breast cancer tissue; significant correlation to tumor grade.
    Aglan SA, Awad AM, Elwany YN, Shawky S, Salam RMA, Omar RS, Ghazala RAM, Soliman NA, Khedr MI, Kandil LS, Sultan M, Hamed Y, Kandil NS., Free PMC Article

    09/13/2024
    Regulation of platelet activation and thrombus formation in acute non-ST segment elevation myocardial infarction: Role of Beclin1.

    Regulation of platelet activation and thrombus formation in acute non-ST segment elevation myocardial infarction: Role of Beclin1.
    Ma L, Sun W, Li J, Wang H, Ding Z, He Q, Kang Y, Dong S, Chu Y., Free PMC Article

    08/30/2024
    VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy.

    VCP/p97 UFMylation stabilizes BECN1 and facilitates the initiation of autophagy.
    Wang Z, Xiong S, Wu Z, Wang X, Gong Y, Zhu WG, Xu X.,

    08/27/2024
    TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1.

    TMEM9 activates Rab9-dependent alternative autophagy through interaction with Beclin1.
    Baek S, Chang JW, Yoo SM, Choo J, Jung S, Nah J, Jung YK., Free PMC Article

    07/31/2024
    Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.

    Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.
    Guo R, Liu J, Min X, Zeng W, Shan B, Zhang M, He Z, Zhang Y, He K, Yuan J, Xu D.

    06/28/2024
    Upregulation of miR-499a Targets Beclin1 to Modulate Astrocyte Autophagy and Promote Ischemic Stroke.

    Upregulation of miR-499a Targets Beclin1 to Modulate Astrocyte Autophagy and Promote Ischemic Stroke.
    Xian G, Song D, Wei Y, Huang F, Luo H.

    04/4/2024
    Targeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC.

    Targeting IL-6/STAT3 signaling abrogates EGFR-TKI resistance through inhibiting Beclin-1 dependent autophagy in HNSCC.
    Wang Y, Zhou Q, Liu C, Zhang R, Xing B, Du J, Dong L, Zheng J, Chen Z, Sun M, Yao X, Ren Y, Zhou X.

    03/19/2024
    VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.

    VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.
    Wang Z, Yan M, Ye L, Zhou Q, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B, Lu Z, Xu D., Free PMC Article

    03/19/2024
    THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.

    THSD1 Suppresses Autophagy-Mediated Focal Adhesion Turnover by Modulating the FAK-Beclin 1 Pathway.
    Xu Z, Lu J, Gao S, Rui YN., Free PMC Article

    03/13/2024
    Clinical roles of autophagy-related proteins Beclin-1 and mTOR in smoking and non-smoking patients with oral leukoplakia.

    Clinical roles of autophagy-related proteins Beclin-1 and mTOR in smoking and non-smoking patients with oral leukoplakia.
    Zhang P, Zhou P, Yao M., Free PMC Article

    02/15/2024
    GRB2 is a BECN1 interacting protein that regulates autophagy.

    GRB2 is a BECN1 interacting protein that regulates autophagy.
    Montero-Vergara J, Plachetta K, Kinch L, Bernhardt S, Kashyap K, Levine B, Thukral L, Vetter M, Thomssen C, Wiemann S, Peña-Llopis S, Jendrossek V, Vega-Rubin-de-Celis S., Free PMC Article

    01/26/2024
    [Pro-oxidation status of rotator cuff tissue and expression of Beclin-1 and mTOR in patients with rotator cuff injury].

    [Pro-oxidation status of rotator cuff tissue and expression of Beclin-1 and mTOR in patients with rotator cuff injury].
    Liu ZJ, Wei HW, Zheng WP, Wan L, Liao ZH, Chen S.

    01/3/2024
    LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.

    LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
    Xu M, Zhou Y.

    12/18/2023
    hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.

    hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.
    Fan H, Zhou D, Zhang X, Jiang M, Kong X, Xue T, Gao L, Lu D, Tao C, Wang L.

    11/13/2023
    Structural insights for selective disruption of Beclin 1 binding to Bcl-2.

    Structural insights for selective disruption of Beclin 1 binding to Bcl-2.
    Pan YZ, Liang Q, Tomchick DR, De Brabander JK, Rizo J., Free PMC Article

    11/1/2023
    COTE1 Facilitates Intrahepatic Cholangiocarcinoma Progression via Beclin1-Dependent Autophagy Inhibition.

    COTE1 Facilitates Intrahepatic Cholangiocarcinoma Progression via Beclin1-Dependent Autophagy Inhibition.
    Zhang H, Chen S, Xu S, Li X., Free PMC Article

    10/5/2023
    Investigation of Beclin 1 and TNF-alpha expressions in preeclampsia placentas: Immunohistochemical study.

    Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas: Immunohistochemical study.
    Öcal E, Toprak V, Akalin SA, Aşir F, Deveci E., Free PMC Article

    08/25/2023
    SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.

    SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
    Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F.

    06/25/2023
    SPINK1 contributes to proliferation and clonal formation of HT29 cells through Beclin1 associated enhanced autophagy.

    SPINK1 contributes to proliferation and clonal formation of HT29 cells through Beclin1 associated enhanced autophagy.
    Hu NA, Zhang S, Jin A, Guo L, Qu Z, Wang J., Free PMC Article

    06/22/2023
    Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma.

    Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma.
    Huang S, Zhang J, Li Y, Xu Y, Jia H, An L, Wang X, Yang Y., Free PMC Article

    06/21/2023
    Genetically prolonged beige fat in male mice confers long-lasting metabolic health.

    Genetically prolonged beige fat in male mice confers long-lasting metabolic health.
    Wu R, Park J, Qian Y, Shi Z, Hu R, Yuan Y, Xiong S, Wang Z, Yan G, Ong SG, Song Q, Song Z, Mahmoud AM, Xu P, He C, Arpke RW, Kyba M, Shu G, Jiang Q, Jiang Y., Free PMC Article

    06/2/2023
    Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia.

    Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia.
    Kamal AM, Nabih NA, Rakha NM, Sanad EF., Free PMC Article

    05/30/2023
    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.

    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy.
    Popli P, Tang S, Chadchan SB, Talwar C, Rucker EB 3rd, Guan X, Monsivais D, Lydon JP, Stallings CL, Moley KH, Kommagani R., Free PMC Article

    05/28/2023
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