| Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression. | Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
Gu C, Wiest M, Zhang W, Halder K, Zurawski S, Zurawski G, Joo H, Oh S. | 06/26/2023 |
| Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics. | Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
Su Z, Luo L, Wu X, Wei B, Wang L, Liu F, Cai B. | 06/18/2022 |
| TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain. | TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
Wang L, Yang HY, Zang CX, Shang JM, Liu H, Zhang ZH, Yuan FY, Ju C, Li FY, Bao XQ, Zhang D. | 03/26/2022 |
| Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker. | Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
Chen AX, Gartrell RD, Zhao J, Upadhyayula PS, Zhao W, Yuan J, Minns HE, Dovas A, Bruce JN, Lasorella A, Iavarone A, Canoll P, Sims PA, Rabadan R., Free PMC Article | 02/19/2022 |
| Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells. | Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
Xing Q, Feng Y, Sun H, Yang S, Sun T, Guo X, Ji F, Wu B, Zhou D. | 12/11/2021 |
| Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures. | Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
Alberts A, Klingberg A, Hoffmeister L, Wessig AK, Brand K, Pich A, Neumann K., Free PMC Article | 07/3/2021 |
| Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants. | Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
López EL, Ferolla FM, Toledano A, Yfran EW, Giordano AC, Carrizo B, Feldman F, Talarico LB, Caratozzolo A, Contrini MM, Acosta PL, GUTI Respiratory Infections Network. | 06/19/2021 |
| Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function. | Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
La Fleur L, Botling J, He F, Pelicano C, Zhou C, He C, Palano G, Mezheyeuski A, Micke P, Ravetch JV, Karlsson MCI, Sarhan D. | 05/15/2021 |
| Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis. | Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
Kanno S, Hirano S, Sakamoto T, Furuyama A, Takase H, Kato H, Fukuta M, Aoki Y., Free PMC Article | 05/1/2021 |
| MARCO is involved in hepatocellular carcinoma (HCC)progression and it can be defined as a novel probable biomarker as well as treatment target for HCC. | Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma.
Xiao Y, Chen B, Yang K, Wang Q, Liu P, Gu Y, Zhong Q, Liu Z, He Y, Liu Q. | 07/4/2020 |
| Q452 and F282 are important for ligand association and phagocytosis of bacteria. Q452 and F282 are examples of positively selected mutations in MARCO, and both enhance the intrinsic function of the receptor. | Human-Specific Mutations and Positively Selected Sites in MARCO Confer Functional Changes.
Novakowski KE, Yap NVL, Yin C, Sakamoto K, Heit B, Golding GB, Bowdish DME., Free PMC Article | 02/16/2019 |
| the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. | Entry of Herpes Simplex Virus 1 into Epidermis and Dermal Fibroblasts Is Independent of the Scavenger Receptor MARCO.
Thier K, Möckel M, Palitzsch K, Döhner K, Sodeik B, Knebel-Mörsdorf D., Free PMC Article | 07/28/2018 |
| High surface expression of SR-A6 facilitates HAdV-C5 infection. | Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.
Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun A, May T, Köster M, Fejer G, Greber UF., Free PMC Article | 06/30/2018 |
| These data suggest the SRCR domain of MARCO is the key domain in modulating ligand binding, enhancing downstream pro-inflammatory signaling and MARCO-mediated cellular adhesion. | A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function.
Novakowski KE, Huynh A, Han S, Dorrington MG, Yin C, Tu Z, Pelka P, Whyte P, Guarné A, Sakamoto K, Bowdish DM., Free PMC Article | 12/2/2017 |
| Expression of MARCO declined progressively as hepatocellular carcinoma condition is aggravated. | Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma.
Sun H, Song J, Weng C, Xu J, Huang M, Huang Q, Sun R, Xiao W, Sun C. | 10/14/2017 |
| MARCO single nucleotide polymorphisms rs12998782 increases risk to pulmonary tuberculosis in a Chinese Han population. | Evaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population.
Lao W, Kang H, Jin G, Chen L, Chu Y, Sun J, Sun B., Free PMC Article | 10/14/2017 |
| CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population. | Evaluation of the relationship between CD36 and MARCO single-nucleotide polymorphisms and susceptibility to carotid atherosclerosis in a Chinese Han population.
Chu Y, Lao W, Jin G, Dai D, Chen L, Kang H. | 09/30/2017 |
| Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. | Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.
Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L., Free PMC Article | 08/5/2017 |
| results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of pulmonary tuberculosis | MARCO variants are associated with phagocytosis, pulmonary tuberculosis susceptibility and Beijing lineage.
Thuong NT, Tram TT, Dinh TD, Thai PV, Heemskerk D, Bang ND, Chau TT, Russell DG, Thwaites GE, Hawn TR, Caws M, Dunstan SJ., Free PMC Article | 05/20/2017 |
| this paper shows that key gene of intermediate proinflammatory monocytes, such as MARCO, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis | Intermediate monocytes are increased in enthesitis-related arthritis, a category of juvenile idiopathic arthritis.
Gaur P, Myles A, Misra R, Aggarwal A., Free PMC Article | 05/13/2017 |
| this study shows that MARCO modulates inflammatory responses against Cryptococcus neoformans infection | Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.
Xu J, Flaczyk A, Neal LM, Fa Z, Eastman AJ, Malachowski AN, Cheng D, Moore BB, Curtis JL, Osterholzer JJ, Olszewski MA., Free PMC Article | 05/6/2017 |
| this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. | Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.
High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, Acosta PL, Ciencewicki J, McCaw ZR, Kobzik L, Miller-DeGraff L, Gladwell W, Peden DB, Serra ME, Shi M, Weinberg C, Suzuki O, Wang X, Bell DA, Polack FP, Kleeberger SR., Free PMC Article | 02/18/2017 |
| Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. | Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO.
Tsay HJ, Huang YC, Chen YJ, Lee YH, Hsu SM, Tsai KC, Yang CN, Huang FL, Shie FS, Lee LC, Shiao YJ., Free PMC Article | 10/22/2016 |
| identified as a disease-associated molecule in IgG4-related disease by DNA microarray | DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins.
Ohta M, Moriyama M, Maehara T, Gion Y, Furukawa S, Tanaka A, Hayashida JN, Yamauchi M, Ishiguro N, Mikami Y, Tsuboi H, Iizuka-Koga M, Kawano S, Sato Y, Kiyoshima T, Sumida T, Nakamura S., Free PMC Article | 07/2/2016 |
| None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD. | Genetic variations in scavenger and β₂-adrenergic receptors and risk of pulmonary disease.
Thomsen M. | 05/16/2015 |