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    RIPK2 receptor interacting serine/threonine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 8767, updated on 10-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.

    Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.
    Goncharov T, Kőműves LG, Kist M, Castellanos ER, Witt A, Fedorova AV, Izrael-Tomasevic A, Yu K, Keir M, Matsumoto ML, Vucic D.

    01/29/2024
    NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-kB-independent manner.

    NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2- and NF-ĸB-independent manner.
    Hezinger L, Bauer S, Ellwanger K, Piotrowsky A, Biber F, Venturelli S, Kufer TA.

    11/16/2023
    Mechanism of Human Cytomegalovirus-Induced Epithelial-Mesenchymal Transition in Glioma Cells via the Upregulation of RIP2 Expression.

    Mechanism of Human Cytomegalovirus-Induced Epithelial-Mesenchymal Transition in Glioma Cells via the Upregulation of RIP2 Expression.
    Cui K, Wang X, Han C, Liu S, Hu Y.

    11/7/2023
    Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-kappaB/JNK/ERK phosphorylation.

    Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation.
    Jiao J, Ruan L, Cheng CS, Wang F, Yang P, Chen Z., Free PMC Article

    04/6/2023
    Expression and Prognostic Value of PIK3CA, VEGF, IL-8, IL-10, and RIP2 in Diffuse Large B-Cell Lymphoma.

    Expression and Prognostic Value of PIK3CA, VEGF, IL-8, IL-10, and RIP2 in Diffuse Large B-Cell Lymphoma.
    Shen N, Yu Y, Zhang R, Guo Y, Liu M, Tan M, Liu J, Bai J, Li L, Liu K, Wang R, He J., Free PMC Article

    01/14/2023
    Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistance.

    Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistance.
    Wang XL, Jiao BH, Wu JL, Yang JK, Hu YH, Cui K., Free PMC Article

    11/5/2022
    RIP2 Knockdown Attenuates Vascular Smooth Muscle Cells Activation via Negative Regulating Myocardin Expression.

    RIP2 Knockdown Attenuates Vascular Smooth Muscle Cells Activation via Negative Regulating Myocardin Expression.
    Zhang L, Huang QW, Pu YF, Xiao XQ, Song BJ, Zhang XP, Yang YS, Zhang YS, Gong FH.

    05/21/2022
    Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction.

    Pan-cancer analysis reveals RIPK2 predicts prognosis and promotes immune therapy resistance via triggering cytotoxic T lymphocytes dysfunction.
    Song J, Yang R, Wei R, Du Y, He P, Liu X., Free PMC Article

    05/14/2022
    High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer.

    High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer.
    Shen Y, Lin H, Chen K, Ge W, Xia D, Wu Y, Lu W., Free PMC Article

    05/14/2022
    A pancancer analysis of the carcinogenic role of receptor-interacting serine/threonine protein kinase-2 (RIPK2) in human tumours.

    A pancancer analysis of the carcinogenic role of receptor-interacting serine/threonine protein kinase-2 (RIPK2) in human tumours.
    Zhang H, Ma Y, Zhang Q, Liu R, Luo H, Wang X., Free PMC Article

    05/14/2022
    Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.

    Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
    Sun H, Li N, Tan J, Li H, Zhang J, Qu L, Lamont SJ., Free PMC Article

    04/23/2022
    Activation of RIPK2-mediated NOD1 signaling promotes proliferation and invasion of ovarian cancer cells via NF-kappaB pathway.

    Activation of RIPK2-mediated NOD1 signaling promotes proliferation and invasion of ovarian cancer cells via NF-κB pathway.
    Zhang W, Wang Y.

    03/19/2022
    Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-kappaB pathway.

    Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway.
    Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome K, Harada K, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Moroishi T, Komohara Y, Sawa T, Baba H.

    03/12/2022
    Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.

    Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis.
    Yan Y, Zhou B, Qian C, Vasquez A, Kamra M, Chatterjee A, Lee YJ, Yuan X, Ellis L, Di Vizio D, Posadas EM, Kyprianou N, Knudsen BS, Shah K, Murali R, Gertych A, You S, Freeman MR, Yang W., Free PMC Article

    02/26/2022
    RIP2 knockdown inhibits cartilage degradation and oxidative stress in IL-1beta-treated chondrocytes via regulating TRAF3 and inhibiting p38 MAPK pathway.

    RIP2 knockdown inhibits cartilage degradation and oxidative stress in IL-1β-treated chondrocytes via regulating TRAF3 and inhibiting p38 MAPK pathway.
    Pan D, Lyu Y, Zhang N, Wang X, Lei T, Liang Z.

    11/27/2021
    14-3-3 and erlin proteins differentially interact with RIPK2 complexes.

    14-3-3 and erlin proteins differentially interact with RIPK2 complexes.
    Steinle H, Ellwanger K, Mirza N, Briese S, Kienes I, Pfannstiel J, Kufer TA.

    09/4/2021
    RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.

    RIPK2 is an unfavorable prognosis marker and a potential therapeutic target in human kidney renal clear cell carcinoma.
    Li D, Tang L, Liu B, Xu S, Jin M, Bo W., Free PMC Article

    08/21/2021
    Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer.

    Receptor-Interacting Serine/Threonine-Protein Kinase-2 as a Potential Prognostic Factor in Colorectal Cancer.
    Jaafar RF, Ibrahim Z, Ataya K, Hassanieh J, Ard N, Faraj W., Free PMC Article

    08/14/2021
    Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism.

    Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism.
    Zhou Y, Hu L, Tang W, Li D, Ma L, Liu H, Zhang S, Zhang X, Dong L, Shen X, Chen S, Xue R, Zhang S., Free PMC Article

    06/19/2021
    Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.

    Autophagy Regulatory Genes MET and RIPK2 Play a Prognostic Role in Pancreatic Ductal Adenocarcinoma: A Bioinformatic Analysis Based on GEO and TCGA.
    Li X, Li Z, Zhu H, Yu X., Free PMC Article

    04/17/2021
    Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.

    Fusobacterium nucleatum Promotes Metastasis in Colorectal Cancer by Activating Autophagy Signaling via the Upregulation of CARD3 Expression.
    Chen Y, Chen Y, Zhang J, Cao P, Su W, Deng Y, Zhan N, Fu X, Huang Y, Dong W., Free PMC Article

    04/3/2021
    Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.

    Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism.
    Groeger S, Denter F, Lochnit G, Schmitz ML, Meyle J., Free PMC Article

    10/24/2020
    findings firstly exhibit that the G allele of rs39509 in nearGene-3 region of RIPK2 might serve as a hazard for TB in this Western Chinese Han population

    RIPK2 polymorphisms and susceptibility to tuberculosis in a Western Chinese Han population.
    Song J, Liu T, Jiao L, Zhao Z, Hu X, Wu Q, Bai H, Lv M, Meng Z, Wu T, Chen H, Chen X, Song X, Ying B.

    05/30/2020
    Results demonstrate an essential role of phosphorylation of RIPK2 at Y474 for the inflammatory function and cytosolic RIPosome formation, whereas lack of phosphorylation at S176 can facilitate complex formation.

    XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures.
    Ellwanger K, Briese S, Arnold C, Kienes I, Heim V, Nachbur U, Kufer TA., Free PMC Article

    01/18/2020
    these results point to a plausible role for genetic polymorphisms in IL23R and RIPK2 in the development and severity of acute pancreatitis.

    Association between Genetic Polymorphisms of Inflammatory Response Genes and Acute Pancreatitis.
    Rodriguez-Nicolas A, Jiménez P, Carmona FD, Martín J, Matas Cobos AM, Ruiz-Cabello F, Redondo-Cerezo E.

    12/14/2019
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