| TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis. | TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis.
Yang WJ, Han FH, Gu YP, Qu H, Liu J, Shen JH, Leng Y., Free PMC Article | 08/9/2024 |
| Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis. | Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Yang CY, Lien CI, Tseng YC, Tu YF, Kulczyk AW, Lu YC, Wang YT, Su TW, Hsu LC, Lo YC, Lin SC., Free PMC Article | 05/23/2024 |
| cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes. | cFLIP(S) regulates alternative NLRP3 inflammasome activation in human monocytes.
Gao Y, Yu S, Chen M, Wang X, Pan L, Wei B, Meng G., Free PMC Article | 10/5/2023 |
| c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression. | c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression.
Wang WD, Shang Y, Wang C, Ni J, Wang AM, Li GJ, Su L, Chen SZ., Free PMC Article | 01/28/2023 |
| The interaction of CFLAR with p130Cas promotes cell migration. | The interaction of CFLAR with p130Cas promotes cell migration.
Li H, Li L, Qiu X, Zhang J, Hua Z. | 01/7/2023 |
| cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. | cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells.
Mora-Molina R, Stöhr D, Rehm M, López-Rivas A., Free PMC Article | 04/16/2022 |
| The deubiquitinase Usp27x as a novel regulator of cFLIPL protein expression and sensitizer to death-receptor-induced apoptosis. | The deubiquitinase Usp27x as a novel regulator of cFLIP(L) protein expression and sensitizer to death-receptor-induced apoptosis.
Dold MN, Ng X, Alber C, Gentle IE, Häcker G, Weber A., Free PMC Article | 03/26/2022 |
| Lactucin induces apoptosis through reactive oxygen species-mediated BCL-2 and CFLARL downregulation in Caki-1 cells. | Lactucin induces apoptosis through reactive oxygen species-mediated BCL-2 and CFLAR(L) downregulation in Caki-1 cells.
Jang JH, Park CY, Sung EG, Song IH, Kim JY, Jung C, Sohn HY, Lee TJ. | 03/12/2022 |
| Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells. | Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.
Huangfu J, Hao C, Wei Z, Wormstone IM, Yan H, Fan X., Free PMC Article | 10/16/2021 |
| The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L). | The SCF(Skp2) ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB., Free PMC Article | 09/25/2021 |
| Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP. | Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP.
Hirpara JL, Subramaniam K, Bellot G, Qu J, Seah S, Loh T, Tucker-Kellogg L, Clement MV, Pervaiz S., Free PMC Article | 04/17/2021 |
| Co-treatment of birinapant with TRAIL synergistically induces apoptosis by downregulating cFLIP(L) in MDA-MB-453 cell lines. | Co-treatment of birinapant with TRAIL synergistically induces apoptosis by downregulating cFLIP(L) in MDA-MB-453 cell lines.
Park EJ, Kim HD, Choi EK, Hoe KL, Kim DU. | 03/20/2021 |
| Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly. | Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly.
Hillert LK, Ivanisenko NV, Espe J, König C, Ivanisenko VA, Kähne T, Lavrik IN. | 11/28/2020 |
| Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma. | Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma.
Vanbervliet-Defrance B, Delaunay T, Daunizeau T, Kepenekian V, Glehen O, Weber K, Estornes Y, Ziverec A, Djemal L, Delphin M, Lantuéjoul S, Passot G, Grégoire M, Micheau O, Blanquart C, Renno T, Fonteneau JF, Lebecque S, Mahtouk K. | 08/15/2020 |
| c-FLIP and NF-kappaB are both required for inhibiting cell death and ensuring survival in a complex CD95-FLIP-NF-kappaB-signaling circuit in renal cell carcinoma. | c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma.
Luebke T, Schwarz L, Beer YY, Schumann S, Misterek M, Sander FE, Plaza-Sirvent C, Schmitz I., Free PMC Article | 06/27/2020 |
| High c-FLIP expression is associated with lung squamous cell carcinoma. | Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy.
Zheng H, Zhang Y, Zhan Y, Liu S, Lu J, Wen Q, Fan S., Free PMC Article | 04/18/2020 |
| They constitutively express and efficiently utilize c-FLIPL , which prevents their Fas-mediated apoptosis. | Efficient recruitment of c-FLIP(L) to the death-inducing signaling complex leads to Fas resistance in natural killer-cell lymphoma.
Masuda A, Isobe Y, Sugimoto K, Yoshimori M, Arai A, Komatsu N., Free PMC Article | 03/21/2020 |
| enhancement of DR5 expression and inhibition of cFLIP expression by genome editing had a synergistic effect of inhibiting proliferation and inducing apoptosis in TRAIL-resistant HeLa cells | CRISPR-mediated upregulation of DR5 and downregulation of cFLIP synergistically sensitize HeLa cells to TRAIL-mediated apoptosis.
Poondla N, Chandrasekaran AP, Heese K, Kim KS, Ramakrishna S. | 02/15/2020 |
| Combining the release of the c-FLIP brake with TLR3 ligand synergizes to selectively kill cancer cells. | Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis.
Alkurdi L, Virard F, Vanbervliet B, Weber K, Toscano F, Bonnin M, Le Stang N, Lantuejoul S, Micheau O, Renno T, Lebecque S, Estornes Y., Free PMC Article | 11/23/2019 |
| Down-regulation of CFLAR increased apoptosis. | Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release.
Faiz A, Heijink IH, Vermeulen CJ, Guryev V, van den Berge M, Nawijn MC, Pouwels SD., Free PMC Article | 10/26/2019 |
| In this review, we tried to collect and examine investigations that researchers have been able to sensitize cancer cells to TRAIL through targeting of c-FLIP alone or with other intracellular anti-apoptotic proteins directly or indirectly. | Down-regulation of intracellular anti-apoptotic proteins, particularly c-FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL.
Hassanzadeh A, Farshdousti Hagh M, Alivand MR, Akbari AAM, Shams Asenjan K, Saraei R, Solali S. | 10/5/2019 |
| Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells. | Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells.
Mauro-Lizcano M, López-Rivas A., Free PMC Article | 09/21/2019 |
| The findings reveal a novel mechanism by which inhibition of GSK-3beta promotes lysosome-dependent degradation of c-FLIPL. | Glycogen synthase kinase-3β inhibition promotes lysosome-dependent degradation of c-FLIP(L) in hepatocellular carcinoma.
Zhang N, Liu X, Liu L, Deng Z, Zeng Q, Pang W, Liu Y, Song D, Deng H., Free PMC Article | 09/14/2019 |
| Our findings show the de-ubiquitinase USP40 regulates the ubiquitination and degradation of CFLARL; and GMEB1 acts as a bridge protein for USP40 and CFLARL. Mechanistically, we found GMEB1 inhibits the activation of CASP8 by modulating ubiquitination and degradation of CFLARL | Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR(L) and inhibit apoptosis in human non-small cell lung cancer cells.
An W, Yao S, Sun X, Hou Z, Lin Y, Su L, Liu X., Free PMC Article | 09/7/2019 |
| DTX1 is an E3 ligase for c-FLIP in gastric cancer cells. | c-FLIP is a target of the E3 ligase deltex1 in gastric cancer.
Hsu TS, Mo ST, Hsu PN, Lai MZ., Free PMC Article | 08/3/2019 |