| DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression. | DNA methylation determines the regulation of pregnane X receptor on CYP3A4 expression.
Wang X, Wei L, Yang J, Wang Y, Chen S, Yang K, Meng X, Zhang L. | 10/2/2024 |
| NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction. | NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction.
Mitamura R, Nakano M, Isono M, Kurosawa K, Fukami T, Nakajima M. | 09/20/2023 |
| Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation. | Effect of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of rivaroxaban and edoxaban in patients with nonvalvular atrial fibrillation.
Nakagawa J, Kinjo T, Aiuchi N, Ueno K, Tomita H, Niioka T. | 04/19/2023 |
| Pregnane X receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease. | Pregnane X receptor gene variant rs7643645 and total mortality in subjects with nonalcoholic fatty liver disease.
Käräjämäki AJ, Hukkanen J, Ukkola O. | 02/15/2023 |
| Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients. | Effects of NR1I2 and ABCB1 Genetic Polymorphisms on Everolimus Pharmacokinetics in Japanese Renal Transplant Patients.
Yagishita H, Kagaya H, Saito M, Numakura K, Yamamoto R, Sagehashi R, Habuchi T, Satoh S, Miura M., Free PMC Article | 10/22/2022 |
| Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity. | Relevance of gene polymorphisms of NAT2 and NR1I2 to anti-tuberculosis drug-induced hepatotoxicity.
Wang N, Guo S, Liu H, Ding Y, Yao R, Liu Z, Zhu H, Chen X, Yang X, Chen X, Lu Y. | 09/3/2022 |
| Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. | Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Yoshinari K, Shizu R. | 07/16/2022 |
| Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient's Age. | Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient's Age.
Li W, Osman E, Forssell C, Yuan XM., Free PMC Article | 07/2/2022 |
| No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects. | No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects.
Liu H, Xie Y, Cai T, Xing J. | 06/25/2022 |
| Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. | Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T., Free PMC Article | 05/7/2022 |
| The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance Gq/Gi Signaling. | The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance G(q)/G(i) Signaling.
Xu QY, Wang YJ, Lin LR, Liu LL, Yang TC., Free PMC Article | 05/7/2022 |
| Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway. | Protease-activated receptor type 1 (PAR1) increases CEMP1 gene expression through MAPK/ERK pathway.
Rovai ES, Alves T, Gasparoni LM, França BN, Sipert CR, Kantarci A, Holzhausen M. | 04/30/2022 |
| Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. | Pregnane X Receptor and the Gut-Liver Axis: A Recent Update.
Dutta M, Lim JJ, Cui JY., Free PMC Article | 04/30/2022 |
| Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia. | Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia.
Karpale M, Hukkanen J, Hakkola J., Free PMC Article | 04/16/2022 |
| Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. | Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids.
Smutny T, Bernhauerova V, Smutna L, Tebbens JD, Pavek P. | 04/9/2022 |
| Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals. | Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
de Almeida Velozo C, de Almeida TB, de Azevedo MCVM, Espasandin I, da Cunha Pinto JF, López S, Pizzatti L, Tanuri A, da Silva Santos S, Ribeiro-Alves M, Cardoso CC. | 03/12/2022 |
| Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis. | Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis.
Qin M, Xin Y, Bian Y, Yang X, Xi T, Xiong J., Free PMC Article | 02/26/2022 |
| Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital. | Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital.
Fricke-Galindo I, Jung-Cook H, Martínez-Juárez IE, Monroy-Jaramillo N, Ortega-Vázquez A, Rojas-Tomé IS, Dorado P, Peñas-Lledó E, Llerena A, López-López M. | 02/26/2022 |
| B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation. | B-cell clonogenic activity of HIV-1 p17 variants is driven by PAR1-mediated EGF transactivation.
Giagulli C, Caccuri F, Zorzan S, Bugatti A, Zani A, Filippini F, Manocha E, D'Ursi P, Orro A, Dolcetti R, Caruso A., Free PMC Article | 02/12/2022 |
| PXR Suppresses PPARalpha-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARalpha and PGC1alpha. | PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α.
Shizu R, Ezaki K, Sato T, Sugawara A, Hosaka T, Sasaki T, Yoshinari K., Free PMC Article | 01/22/2022 |
| Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation. | Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation.
Friebel J, Moritz E, Witkowski M, Jakobs K, Strässler E, Dörner A, Steffens D, Puccini M, Lammel S, Glauben R, Nowak F, Kränkel N, Haghikia A, Moos V, Schutheiss HP, Felix SB, Landmesser U, Rauch BH, Rauch U., Free PMC Article | 01/22/2022 |
| Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism. | Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism.
Smutny T, Hyrsova L, Braeuning A, Ingelman-Sundberg M, Pavek P. | 12/25/2021 |
| Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis. | Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis.
Guo H, Chi Y, Chi N., Free PMC Article | 12/11/2021 |
| St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFkappaB antagonism. | St. John's Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism.
Yan T, Luo Y, Xia Y, Hamada K, Wang Q, Yan N, Krausz KW, Ward JM, Hao H, Wang P, Gonzalez FJ., Free PMC Article | 11/22/2021 |
| NR1I2 genetic polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity: A systematic review and meta-analysis. | NR1I2 genetic polymorphisms and the risk of anti-tuberculosis drug-induced hepatotoxicity: A systematic review and meta-analysis.
Yang M, Qiu Y, Jin Y, Liu W, Wang Q, Yi H, Tang S., Free PMC Article | 11/13/2021 |