| LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1alpha-CXCR4 pathway. | LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1α-CXCR4 pathway.
Tu S, Wang XY, Zeng LX, Shen ZJ, Zhang ZH. | 03/19/2022 |
| Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart. | Cardiac-specific VEGFB overexpression reduces lipoprotein lipase activity and improves insulin action in rat heart.
Shang R, Lal N, Lee CS, Zhai Y, Puri K, Seira O, Boushel RC, Sultan I, Räsänen M, Alitalo K, Hussein B, Rodrigues B. | 01/8/2022 |
| Loss of VEGFB and its downstream signaling is an early event following hyperglycemia, is sustained with disease progression, and could explain diabetic cardiomyopathy. | Loss of VEGFB and its signaling in the diabetic heart is associated with increased cell death signaling.
Lal N, Chiu AP, Wang F, Zhang D, Jia J, Wan A, Vlodavsky I, Hussein B, Rodrigues B. | 08/12/2017 |
| Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue. | Methylation patterns of Vegfb promoter are associated with gene and protein expression levels: the effects of dietary fatty acids.
Monastero R, García-Serrano S, Lago-Sampedro A, Rodríguez-Pacheco F, Colomo N, Morcillo S, Martín-Nuñez GM, Gomez-Zumaquero JM, García-Fuentes E, Soriguer F, Rojo-Martínez G, García-Escobar E. | 08/12/2017 |
| Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation. | Oral Platelet-Derived Growth Factor and Vascular Endothelial Growth Factor Inhibitor Sunitinib Prevents Chronic Allograft Injury in Experimental Kidney Transplantation Model.
Rintala JM, Savikko J, Palin N, Rintala SE, Koskinen PK, von Willebrand E. | 04/23/2016 |
| Cardiac VEGF-B mRNA expression decreases following heart transplantation. | Cardiac VEGF-B expression decreases along with cardiac allograft unload.
Raissadati A, Tuuminen R. | 08/31/2013 |
| VEGF-B has important effects on the functional architecture of the visual cortex. | Vascular endothelial growth factor B prevents the shift in the ocular dominance distribution of visual cortical neurons in monocularly deprived rats.
Shan L, Yong H, Song Q, Wei Y, Qin R, Zhang G, Xu M, Zhang S. | 06/1/2013 |
| results demonstrate that the vascular endothelium can function as an efficient barrier to excess muscle lipid uptake even under conditions of severe obesity and type 2 diabetes, and that this barrier can be maintained by inhibition of VEGF-B signalling | Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.
Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U. | 12/8/2012 |
| Transcript level of angiogenesis-related genes, Vegfb and its transcription factor gene, Hif1a, those being downstream of phosphatase and tensin homolog (PTEN)/Akt signaling, were up-regulated in the thyroid tissue with Cochineal extracts administration. | Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats.
Kemmochi S, Shimamoto K, Shiraki A, Onda N, Hasumi K, Suzuki K, Mitsumori K, Shibutani M. | 10/20/2012 |
| VEGFB and PlGF can either inhibit or potentiate the actions of VEGFA, depending on their relative concentrations, which change in the hypoxic lung. | Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung.
Sands M, Howell K, Costello CM, McLoughlin P., Free PMC Article | 05/7/2011 |
| VEGF-B appears to be a coronary growth factor in rats but not in mice. | Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.
Bry M, Kivelä R, Holopainen T, Anisimov A, Tammela T, Soronen J, Silvola J, Saraste A, Jeltsch M, Korpisalo P, Carmeliet P, Lemström KB, Shibuya M, Ylä-Herttuala S, Alhonen L, Mervaala E, Andersson LC, Knuuti J, Alitalo K. | 11/27/2010 |