| miR-14 2-3 p not only mitigate cardiac hypertrophy by directly inhibit the expression of gene SH2B1, but also can protect mitochondrial function in cardiac hypertrophy of vitro and vivo. | Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy.
Liu BL, Cheng M, Hu S, Wang S, Wang L, Tu X, Huang CX, Jiang H, Wu G. | 03/23/2019 |
| SH2B1 overexpression resulted in increased viability, reduced lactate dehydrogenase release and a reduction in the expression levels of proteins associated with the apoptotic cascade in PC12 cells under the oxygenglucose deprivation condition. | SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway.
Yuan J, Zeng L, Sun Y, Wang N, Sun Q, Cheng Z, Wang Y., Free PMC Article | 10/27/2018 |
| These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching. | SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches.
Chen CJ, Shih CH, Chang YJ, Hong SJ, Li TN, Wang LH, Chen L., Free PMC Article | 05/23/2015 |
| findings demonstrate that SH2B1beta promotes BDNF-induced neurite outgrowth through enhancing pathways involved MEK-ERK1/2 and PI3K-AKT. | New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth.
Shih CH, Chen CJ, Chen L., Free PMC Article | 07/12/2014 |
| Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats | Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ. | 05/26/2012 |
| These findings provide significant new insights into how N-cadherin-mediated inter-cellular interactions may influence neurite initiation and how SH2B1beta may regulate these processes. | SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation.
Wang TC, Li YH, Chen KW, Chen CJ, Wu CL, Teng NY, Chen L. | 07/30/2011 |
| SH2B1beta must shuttle between the plasma membrane and nucleus to function as a critical component of NGF-induced gene expression and neuronal differentiation. | Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.
Maures TJ, Chen L, Carter-Su C., Free PMC Article | 01/21/2010 |
| SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway. | SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.
Lin WF, Chen CJ, Chang YJ, Chen SL, Chiu IM, Chen L. | 01/21/2010 |
| Results suggest that SH2B1beta stimulates NGF-induced neuronal differentiation at least in part by enhancing expression of a specific subset of NGF-sensitive genes, including Plaur, Mmp3, and/or Mmp10, required for neurite outgrowth. | SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.
Chen L, Maures TJ, Jin H, Huo JS, Rabbani SA, Schwartz J, Carter-Su C., Free PMC Article | 01/21/2010 |
| SH2-Bbeta and APS do not activate JAK2 as a consequence of their own dimerization, recruitment of an activator of JAK2, or direct competition with a JAK2 inhibitor for binding to JAK2. They most likely induce or stabilize an active conformation of JAK2. | Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.
Kurzer JH, Saharinen P, Silvennoinen O, Carter-Su C., Free PMC Article | 01/21/2010 |
| SH2-B is a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway. | SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.
Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C. | 01/21/2010 |
| data suggest that SH2-B beta shuttles constitutively between the nucleus and cytoplasm, and that the stimulatory effect of SH2-B beta on NGF-induced neurite outgrowth is either downstream of ERKs or via some other pathway yet to be identified. | Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation.
Chen L, Carter-Su C., Free PMC Article | 01/21/2010 |