| Clinical implications of activation of the LIMD1-VHL-HIF1alpha pathway during head-&-neck squamous cell carcinoma development. | Clinical implications of activation of the LIMD1-VHL-HIF1α pathway during head-&-neck squamous cell carcinoma development.
Mukhopadhyay D, Chakraborty B, Sarkar S, Alam N, Panda CK., Free PMC Article | 10/18/2024 |
| LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force. | LIMD1 phase separation contributes to cellular mechanics and durotaxis by regulating focal adhesion dynamics in response to force.
Wang Y, Zhang C, Yang W, Shao S, Xu X, Sun Y, Li P, Liang L, Wu C. | 09/25/2021 |
| High nuclear expression of HIF1alpha, synergizing with inactivation of LIMD1 and VHL, portray worst prognosis among the bladder cancer patients: association with arsenic prevalence. | High nuclear expression of HIF1α, synergizing with inactivation of LIMD1 and VHL, portray worst prognosis among the bladder cancer patients: association with arsenic prevalence.
Basu M, Chatterjee A, Chakraborty B, Chatterjee E, Ghosh S, Samadder S, Pal DK, Roy A, Chakrabarti J, Ghosh A, Panda CK. | 07/10/2021 |
| findings suggest that LIMD1 is a key regulator of mitotic progression, and that dysregulation of LIMD1 contributes to tumorigenesis | LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor-suppressing activity.
Zhou J, Zhang L, Zhou W, Chen Y, Cheng Y, Dong J. | 12/14/2019 |
| We show that all three mammalian Ajuba family proteins - AJUBA, LIMD1 and WTIP - exhibit tension-dependent localization to adherens junctions, and that both LATS family proteins, LATS1 and LATS2, exhibit an overlapping tension-dependent junctional localization | Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine KD., Free PMC Article | 09/14/2019 |
| Kaposi's sarcoma-associated herpesvirus SOX binds to LIMD1 and shows RNA substrate selectivity | Site specific target binding controls RNA cleavage efficiency by the Kaposi's sarcoma-associated herpesvirus endonuclease SOX.
Mendez AS, Vogt C, Bohne J, Glaunsinger BA., Free PMC Article | 07/20/2019 |
| The lung tumor suppressor protein LIMD1 is a member of the Zyxin family of adaptor proteins, initially characterized as signal transducers shuttling between the cytoplasm and nucleus. LIMD1 expression promotes tumor growth. | A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia.
Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang TY, Shaw PE, Reynolds LE, McKay TR, Wang HW, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I, Sharp TV., Free PMC Article | 04/27/2019 |
| Low LIMD1 expression is associated with cervical cancer. | Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.
Chakraborty C, Mitra S, Roychowdhury A, Samadder S, Dutta S, Roy A, Das P, Mandal RK, Sharp TV, Roychoudhury S, Panda CK. | 02/16/2019 |
| that the reduced expression of LimD1 and VHL might have synergistic effect on induction of HIF1alpha resulting increased cellular proliferation and progression of the disease. | Over expression of HIF1α is associated with inactivation of both LimD1 and VHL in renal cell carcinoma: Clinical importance.
Sur S, Maurya AK, Roy A, Sharp TV, Pal DK, Panda CK. | 08/11/2018 |
| our data also suggests the importance ofLIMD1 and CDC25A in conjunction with HPV for use as diagnostic and prognostic markers of HNSCC, whereas RBSP3 as a prognostic marker only. | Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study.
Sarkar S, Alam N, Mandal SS, Chatterjee K, Ghosh S, Roychoudhury S, Panda CK., Free PMC Article | 07/28/2018 |
| LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by binding both proteins simultaneously at distinct interfaces. | Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.
Bridge KS, Shah KM, Li Y, Foxler DE, Wong SCK, Miller DC, Davidson KM, Foster JG, Rose R, Hodgkinson MR, Ribeiro PS, Aboobaker AA, Yashiro K, Wang X, Graves PR, Plevin MJ, Lagos D, Sharp TV., Free PMC Article | 03/31/2018 |
| These results suggested that LIMD1 is a novel BRCA2-interacting protein and is involved in the centrosome localization of BRCA2 and suppression of LIMD1, causing abnormal cell division in EC cells. | Novel BRCA2-Interacting Protein, LIMD1, Is Essential for the Centrosome Localization of BRCA2 in Esophageal Cancer Cell.
Hou X, Li T, Ren Z, Liu Y., Free PMC Article | 03/18/2017 |
| Thus, the LIMD1-MYBL1 Index had considerable clinical value for DLBCL subtype classification and prognosis. | Identification and validation of a two-gene expression index for subtype classification and prognosis in Diffuse Large B-Cell Lymphoma.
Xu Q, Tan C, Ni S, Wang Q, Wu F, Liu F, Ye X, Meng X, Sheng W, Du X., Free PMC Article | 02/27/2016 |
| Cyclic stretch is associated with a JNK-dependent increase in binding of a LATS inhibitor, LIMD1, to the LATS1 kinase and that reduction of LIMD1 expression suppresses the activation of YAP by cyclic stretch. | Regulation of YAP by mechanical strain through Jnk and Hippo signaling.
Codelia VA, Sun G, Irvine KD., Free PMC Article | 05/23/2015 |
| LIMD1 prevents retinoblastoma phosphorylation and downregulates of E2F1 protein and blocks entry of cells into S-phase. | LIMD1 antagonizes E2F1 activity and cell cycle progression by enhancing Rb function in cancer cells.
Mayank AK, Sharma S, Deshwal RK, Lal SK. | 01/17/2015 |
| Data show that the tumour suppressor protein LIMD1 acts as a molecular scaffold, simultaneously binding the PHDs and VHL, thereby assembling a PHD-LIMD1-VHL protein complex and creating an enzymatic niche that enables efficient degradation of HIF-1alpha. | The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV. | 03/31/2012 |
| PU.1 is a major transcriptional activator of LIMD1 | PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1.
Foxler DE, James V, Shelton SJ, Vallim TQ, Shaw PE, Sharp TV., Free PMC Article | 05/28/2011 |
| LIMD1 inactivation as primary event than inactivation of RB1 in head and neck squamous cell carcinoma development. | LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications.
Ghosh S, Ghosh A, Maiti GP, Mukherjee N, Dutta S, Roy A, Roychoudhury S, Panda CK, Ghosh S, Ghosh A, Maiti GP, Mukherjee N, Dutta S, Roy A, Roychoudhury S, Panda CK., Free PMC Articles: PMC2848626, PMC2848626 | 05/31/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications.
Ghosh S, Ghosh A, Maiti GP, Mukherjee N, Dutta S, Roy A, Roychoudhury S, Panda CK, Ghosh S, Ghosh A, Maiti GP, Mukherjee N, Dutta S, Roy A, Roychoudhury S, Panda CK., Free PMC Articles: PMC2848626, PMC2848626 | 04/7/2010 |
| LIMD1 is a validated chromosome 3p21.3 tumor-suppressor gene involved in human lung cancer development. | The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM, Nicholson AG, Zhang Q, Kraja A, Spendlove I, Osborne J, Mardis E, Longmore GD., Free PMC Article | 01/21/2010 |
| study demonstrates that LIMD1 represents a novel prognostic marker for breast cancer. Combined with the fact that LIMD1 expression is downregulated in lung cancers this clearly indicates that LIMD1 may represent a critical tumor suppressor gene | Differential subcellular localisation of the tumour suppressor protein LIMD1 in breast cancer correlates with patient survival.
Spendlove I, Al-Attar A, Watherstone O, Webb TM, Ellis IO, Longmore GD, Sharp TV. | 01/21/2010 |
| These results suggest that some breast tumors have altered expression of LIMD1 RNA and that LIMD1 may be involved in cell anchoring via focal adhesions and in the cell cycle, particularly during mitosis. | Cell cycle regulated phosphorylation of LIMD1 in cell lines and expression in human breast cancers.
Huggins CJ, Andrulis IL. | 01/21/2010 |
| analysis of hLIMD1 gene variants in breast cancer | Identification of rare variants in the hLIMD1 gene in breast cancer.
Huggins CJ, Gill M, Andrulis IL. | 01/21/2010 |
| LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis | LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription.
Sharp TV, Munoz F, Bourboulia D, Presneau N, Darai E, Wang HW, Cannon M, Butcher DN, Nicholson AG, Klein G, Imreh S, Boshoff C., Free PMC Article | 01/21/2010 |