| An HLA-G/SPAG9/STAT3 axis promotes brain metastases. | An HLA-G/SPAG9/STAT3 axis promotes brain metastases.
Bassey-Archibong BI, Rajendra Chokshi C, Aghaei N, Kieliszek AM, Tatari N, McKenna D, Singh M, Kalpana Subapanditha M, Parmar A, Mobilio D, Savage N, Lam F, Tokar T, Provias J, Lu Y, Chafe SC, Swanton C, Hynds RE, Venugopal C, Singh SK., Free PMC Article | 02/16/2023 |
| Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer. | Significance of cancer testis-associated antigens (SPAG9 and FBXO39) in colon cancer.
Ramadan RA, Morsy H, Samir M, Shamseya M, Shalaby M, El-Attar EA. | 11/26/2022 |
| Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. | Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.
Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM., Free PMC Article | 12/4/2021 |
| Phosphorylation of JIP4 at S730 Presents Antiviral Properties against Influenza A Virus Infection. | Phosphorylation of JIP4 at S730 Presents Antiviral Properties against Influenza A Virus Infection.
Del Sarto J, Gerlt V, Friedrich ME, Anhlan D, Wixler V, Teixeira MM, Boergeling Y, Ludwig S., Free PMC Article | 10/23/2021 |
| miR-874 inhibits gastric cancer cell proliferation by targeting SPAG9. | miR-874 inhibits gastric cancer cell proliferation by targeting SPAG9.
Sun QH, Yin ZX, Li Z, Tian SB, Wang HC, Zhang FX, Li LP, Zheng CN, Kong S., Free PMC Article | 01/23/2021 |
| Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif. | Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif.
Vilela F, Velours C, Chenon M, Aumont-Nicaise M, Campanacci V, Thureau A, Pylypenko O, Andreani J, Llinas P, Ménétrey J., Free PMC Article | 10/31/2020 |
| Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway. | Sperm associated antigen 9 promotes oncogenic KSHV-encoded interferon regulatory factor-induced cellular transformation and angiogenesis by activating the JNK/VEGFA pathway.
Li W, Wang F, Shi J, Feng Q, Chen Y, Qi X, Wang C, Lu H, Lu Z, Jia X, Yan Q, Gao SJ, Lu C., Free PMC Article | 10/10/2020 |
| High SPAG9 expression is associated with drug resistance in anaplastic thyroid carcinoma. | LncRNA NEAT1 enhances the resistance of anaplastic thyroid carcinoma cells to cisplatin by sponging miR‑9‑5p and regulating SPAG9 expression.
Yan P, Su Z, Zhang Z, Gao T., Free PMC Article | 03/14/2020 |
| these data suggest that the TFEB/TMEM55B/JIP4 pathway coordinates lysosome movement in response to a variety of stress conditions. | TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Willett R, Martina JA, Zewe JP, Wills R, Hammond GRV, Puertollano R., Free PMC Article | 09/15/2018 |
| AKAP4 and SPAG9 genes may find use as diagnostic biomarkers for CRC. | AKAP4, SPAG9 and NY-ESO-1 in Iranian Colorectal Cancer Patients as Probable Diagnostic and Prognostic Biomarkers.
Tavakoli Koudehi A, Mahjoubi B, Mirzaei R, Shabani S, Mahjoubi F., Free PMC Article | 08/25/2018 |
| Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer | Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer.
Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN., Free PMC Article | 03/3/2018 |
| SPAG9 mRNA and protein overexpression in lung cancer tissue, and the presence of SPAG9 IgG antibody in peripheral blood of lung cancer patients indicates that it has potential as a biomarker for lung cancer diagnosis. | Cancer testis antigen SPAG9 is a promising marker for the diagnosis and treatment of lung cancer.
Ren B, Wei X, Zou G, He J, Xu G, Xu F, Huang Y, Zhu H, Li Y, Ma G, Yu P., Free PMC Article | 12/31/2016 |
| SPAG9-elevated expression contributes to malignant behavior and poor prognosis of breast cancer and may support a potential indicator in treatment selection. | Sperm-associated antigen 9 overexpression correlates with poor prognosis and insensitive to Taxol treatment in breast cancer.
Yang C, Shen B, Zhang J, Zhang Q. | 12/17/2016 |
| Study suggest that suppression of miR-141 may cause an aberrant overexpression of SPAG9 promoting growth and metastasis of hepatocellular carcinoma cells. | Direct targeting sperm-associated antigen 9 by miR-141 influences hepatocellular carcinoma cell growth and metastasis via JNK pathway.
Lou G, Dong X, Xia C, Ye B, Yan Q, Wu S, Yu Y, Liu F, Zheng M, Chen Z, Liu Y., Free PMC Article | 10/22/2016 |
| expression of SPAG9 in ECC cells with TGF-beta1 treatment and spheroids formation was increased | SPAG9 promotes endometrial carcinoma cell invasion through regulation of genes related to the epithelial-mesenchymal transition.
Zhang L, Yan L, Cao M, Zhang H, Li C, Bai Y, Yu P, Li M, Zhao X. | 07/30/2016 |
| PLK1 binding to JIP4 was found in G2 phase and mitosis, and PLK1 binding was self-primed by PLK1 phosphorylation of JIP4. | JIP4 is a PLK1 binding protein that regulates p38MAPK activity in G2 phase.
Pinder A, Loo D, Harrington B, Oakes V, Hill MM, Gabrielli B. | 07/2/2016 |
| Based on in vitro assays, we found miR-200a-3p significantly inhibit cancer cell proliferation by inducing apoptosis. | MicroRNA-200a-3p suppresses tumor proliferation and induces apoptosis by targeting SPAG9 in renal cell carcinoma.
Wang X, Jiang F, Song H, Li X, Xian J, Gu X. | 06/28/2016 |
| FOXK1 protein levels and activity are regulated by associating with JLP and PLK1 | JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1.
Ramkumar P, Lee CM, Moradian A, Sweredoski MJ, Hess S, Sharrocks AD, Haines DS, Reddy EP., Free PMC Article | 04/23/2016 |
| SPAG9 overexpression in gastric cancer correlates with poor prognosis and contributes to gastric cancer cell proliferation | Overexpression of SPAG9 in human gastric cancer is correlated with poor prognosis.
Miao ZF, Wang ZN, Zhao TT, Xu YY, Wu JH, Liu XY, Xu H, You Y, Xu HM. | 03/12/2016 |
| SPAG9 was upregulated in nonmelanoma skin cancer when compared with normal skin. | Immunohistochemical expression of sperm-associated antigen 9 in nonmelanoma skin cancer.
Seleit I, Bakry OA, Samaka RM, Malak MA. | 07/25/2015 |
| SPAG9 expression is significantly increased in prostate cancer and it may be involved in the process of prostate cancer cell motility, migration and angiogenesis. | SPAG9 expression is increased in human prostate cancer and promotes cell motility, invasion and angiogenesis in vitro.
Chen F, Lu Z, Deng J, Han X, Bai J, Liu Q, Xi Y, Zheng J. | 06/27/2015 |
| knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38. | Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase (JNK)-interacting protein 4 for mitogen-activated protein kinase kinase 4 (MKK4) and suppresses the phosphorylation of MKK4, p38, and JNK, thereby inhibiting apoptosis.
Tanaka T, Iino M, Goto K. | 01/31/2015 |
| SPAG9 upregulates PODXL expression in human astrocytoma cells at the PODXL gene promoter/transcriptional level through a JNKdependent mechanism. | Sperm‑associated antigen 9 promotes astrocytoma cell invasion through the upregulation of podocalyxin.
Jiang J, Liu Y, Fang W, Liu F. | 01/17/2015 |
| SPAG9 is overexpressed in human HCC and serves as a prognostic marker. SPAG9 contributes to cancer cell growth through regulation of cyclin proteins. | Overexpression of SPAG9 correlates with poor prognosis and tumor progression in hepatocellular carcinoma.
Xie C, Fu L, Liu N, Li Q. | 01/17/2015 |
| SPAG9 is overexpressed in human prostate cancers and contributes to prostate cancer cell growth, possibly through cyclin protein regulation. | SPAG9 is overexpressed in human prostate cancer and promotes cancer cell proliferation.
Li H, Peng Y, Niu H, Wu B, Zhang Y, Zhang Y, Bai X, He P. | 10/11/2014 |