| Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis. | Age-related genes USP2 and ARG2 are involved in the reduction of immune cell infiltration in elderly patients with rheumatoid arthritis.
Cheng Q, Chen M, Liu M, Wang F, Chen X, Sun W, Du Y, Wu H. | 02/7/2024 |
| USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination. | USP2 Inhibits Lung Cancer Pathogenesis by Reducing ARID2 Protein Degradation via Ubiquitination.
Zhu L, Chen Z, Guo T, Chen W, Zhao L, Guo L, Pan X., Free PMC Article | 01/14/2023 |
| Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation. | Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.
Hashimoto M, Fujimoto M, Konno K, Lee ML, Yamada Y, Yamashita K, Toda C, Tomura M, Watanabe M, Inanami O, Kitamura H., Free PMC Article | 06/18/2022 |
| Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-beta signaling. | Loss of deubiquitylase USP2 triggers development of glioblastoma via TGF-β signaling.
Tu Y, Xu L, Xu J, Bao Z, Tian W, Ye Y, Sun G, Miao Z, Chao H, You Y, Liu N, Ji J. | 05/7/2022 |
| High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. | High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.
Ke HL, Lee YC, Li WM, Wang CS, Hsu WC, Lin HH, Lee YA, Jhan JH, Li CC, Yeh HC, Wu WJ, Huang AM. | 04/23/2022 |
| Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-kappaB pathway. | Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.
Duan J, Jin M, Yang D, Shi J, Gao J, Guo D, Tang H, Zhang S, Qiao B., Free PMC Article | 03/26/2022 |
| Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage. | Decreased USP2a Expression Inhibits Trophoblast Invasion and Associates With Recurrent Miscarriage.
Wang J, Ding J, Zhang S, Chen X, Yan S, Zhang Y, Yin T., Free PMC Article | 12/25/2021 |
| USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates. | USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.
Zhang F, Zhao Y, Sun Y., Free PMC Article | 11/27/2021 |
| Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. | Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A.
Xiong B, Huang J, Liu Y, Zou M, Zhao Z, Gong J, Wu X, Qiu C. | 10/9/2021 |
| The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer. | The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
Zhang J, Liu S, Li Q, Shi Y, Wu Y, Liu F, Wang S, Zaky MY, Yousuf W, Sun Q, Guo D, Wang T, Zhang Y, Wang Y, Li M, Liu H., Free PMC Article | 09/25/2021 |
| Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21. | Disulfiram and 6-Thioguanine synergistically inhibit the enzymatic activities of USP2 and USP21.
Lin HC, Kuan Y, Chu HF, Cheng SC, Pan HC, Chen WY, Sun CY, Lin TH. | 07/24/2021 |
| USP2-mediated Twist/Bmi1 pathway represents a cell-intrinsic mechanism crucial for CSC regulation besides EMT and provides pre-clinical evidence that targeting USP2 is indeed a promising approach for anti-CSC therapy. | Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.
He J, Lee HJ, Saha S, Ruan D, Guo H, Chan CH., Free PMC Article | 05/9/2020 |
| These findings have characterized an essential role of USP2a as a potential target for treatment of metastatic cancers. | USP2a Supports Metastasis by Tuning TGF-β Signaling.
Zhao Y, Wang X, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B. | 06/22/2019 |
| Data suggest that ubiquitin (Ub) and neural precursor cell expressed developmentally down-regulated 8 (NEDD8) residues 4, 12, 14, and 72 serve as the molecular determinants for specific recognition by ubiquitin specific protease 2 protein (USP2). | The molecular determinants for distinguishing between ubiquitin and NEDD8 by USP2.
Shin YC, Chen JH, Chang SC., Free PMC Article | 01/12/2019 |
| In general, we collect and summarize the factors involved in the alternative splicing of USP2 in this review to further understand the mechanism behind the USP2's alternative splicing | The Molecular Mechanisms of Regulation on USP2's Alternative Splicing and the Significance of Its Products.
Zhu HQ, Gao FH., Free PMC Article | 08/4/2018 |
| Authors show here USP2 is expressed in quiescent and activated T-cells and its expression is 50% lower in CTCL cell lines (MyLa2000, SeAx and Hut-78) than in normal T-cells. | Ubiquitin-specific protease 2 decreases p53-dependent apoptosis in cutaneous T-cell lymphoma.
Wei T, Biskup E, Gjerdrum LM, Niazi O, Ødum N, Gniadecki R., Free PMC Article | 03/17/2018 |
| Data show that ubiquitin variants (Ubvs) that bind to USP2 or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences. | Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21.
Leung I, Dekel A, Shifman JM, Sidhu SS., Free PMC Article | 02/10/2018 |
| The results show a connection between miR-125b and USP2 gene the etiology of psoriasis. They proceeded to show that modulation of nuclear factor kappa B-mediated inflammation is the likely mechanism through which this miRNA gene pair function | Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis.
Wei T, Folkersen L, Biskup E, Xu N, Manfe V, Niazi O, Gniadecki R. | 10/14/2017 |
| the deubiquitinase USP2a translocates into the nucleus and binds to pY701-STAT1, and inhibits K48-linked ubiquitination and degradation of pY701-STAT1 | Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.
Ren Y, Zhao P, Liu J, Yuan Y, Cheng Q, Zuo Y, Qian L, Liu C, Guo T, Zhang L, Wang X, Qian G, Li L, Ge J, Dai J, Xiong S, Zheng H., Free PMC Article | 06/10/2017 |
| ML364 also caused a decrease in homologous recombination-mediated DNA repair. These effects by a small molecule inhibitor support a key role for USP2 as a regulator of cell cycle, DNA repair, and tumor cell growth. | Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.
Davis MI, Pragani R, Fox JT, Shen M, Parmar K, Gaudiano EF, Liu L, Tanega C, McGee L, Hall MD, McKnight C, Shinn P, Nelson H, Chattopadhyay D, D'Andrea AD, Auld DS, DeLucas LJ, Li Z, Boxer MB, Simeonov A., Free PMC Article | 05/27/2017 |
| Identify USP2 as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR by IDOL. | The Deubiquitylase USP2 Regulates the LDLR Pathway by Counteracting the E3-Ubiquitin Ligase IDOL.
Nelson JK, Sorrentino V, Avagliano Trezza R, Heride C, Urbe S, Distel B, Zelcer N. | 07/2/2016 |
| Data suggest up-regulation of ASAH1 (acid ceramidase) activity by androgen in androgen-sensitive prostate cancer cells (but not other cancer cells) is mainly due to prolonged stability of ASAH1 by androgen-stimulated induction of USP2 expression. | Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP.
Mizutani N, Inoue M, Omori Y, Ito H, Tamiya-Koizumi K, Takagi A, Kojima T, Nakamura M, Iwaki S, Nakatochi M, Suzuki M, Nozawa Y, Murate T. | 07/2/2016 |
| Modulation of USP-2 expression plays a crucial role in cell cycle regulation by leptin and adiponectin. | Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells.
Nepal S, Shrestha A, Park PH. | 05/21/2016 |
| Our findings suggest that USP2a mRNA may be considered as a diagnostic marker candidate for bladder cancer, in particular, to stratify MIBC patients with a more invasive phenotype. | Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.
Jeong P, Ha YS, Yun SJ, Yoon HY, Freeman MR, Kim J, Kim WJ., Free PMC Article | 03/5/2016 |
| The present study showed that USP2 expression is associated with TNBC cell line's invasiveness and poor survival of breast cancer patients and may serve as a prognostic biomarker and therapeutic target for TNBC | USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.
Qu Q, Mao Y, Xiao G, Fei X, Wang J, Zhang Y, Liu J, Cheng G, Chen X, Wang J, Shen K. | 10/31/2015 |