| REPS2 downregulation facilitates FGF-induced adhesion and migration in human lens epithelial cells through FAK/Cdc42 signaling and contributes to posterior capsule opacification. | REPS2 downregulation facilitates FGF-induced adhesion and migration in human lens epithelial cells through FAK/Cdc42 signaling and contributes to posterior capsule opacification.
Wen C, Wang C, Hu C, Qi T, Jing R, Wang Y, Zhang M, Shao Y, Pei C. | 08/13/2022 |
| HIV-1 gp41 promotes viral endocytosis in a CD4-independent manner by interacting with the host protein POB1. | Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1.
Tan Y, Wang J, Su S, Wang Q, Jiang S, Lu L, Chen YH., Free PMC Article | 05/11/2019 |
| miR-675-5p might play an oncogenic role in esophageal squamous cell carcinoma (ESCC) through RalBP1/RAC1/CDC42 signaling pathway by inhibiting REPS2 and might serve as a valuable prognostic biomarker and therapeutic target for ESCC patients. | miR-675-5p enhances tumorigenesis and metastasis of esophageal squamous cell carcinoma by targeting REPS2.
Zhou YW, Zhang H, Duan CJ, Gao Y, Cheng YD, He D, Li R, Zhang CF., Free PMC Article | 12/30/2017 |
| downregulation of REPS2 may contribute to malignant progression of esophageal squamous cell carcinoma and represent a novel prognostic marker and a potential therapeutic target for esophageal squamous cell carcinoma patients. | Expression and clinical significance of REPS2 in human esophageal squamous cell carcinoma.
Zhang H, Duan CJ, Zhang H, Cheng YD, Zhang CF. | 01/17/2015 |
| REPS2 may be a useful tumor marker for favorable prognosis in breast cancer. | TMEM25, REPS2 and Meis 1: favourable prognostic and predictive biomarkers for breast cancer.
Doolan P, Clynes M, Kennedy S, Mehta JP, Germano S, Ehrhardt C, Crown J, O'Driscoll L. | 01/21/2010 |
| Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1. | Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1.
Singhal SS, Yadav S, Drake K, Singhal J, Awasthi S., Free PMC Article | 01/21/2010 |
| POB1, through its influence on the Ral signalling pathway, is involved in growth factor signalling and consequently in control of cell proliferation | REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells.
Oosterhoff JK, Penninkhof F, Brinkmann AO, Anton Grootegoed J, Blok LJ. | 01/21/2010 |
| Decreased REPS2 expression is associated with androgen-independent state of advanced prostate cancer | EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2.
Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ. | 01/21/2010 |
| These results suggest that POB1 interacts with PAG2 through its proline-rich motif, thereby regulating cell migration. | Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.
Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A. | 01/21/2010 |
| These results show for the first time that POB1 can regulate the transport function of RLIP76 and are consistent with our previous studies showing that inhibition of RLIP76 induces apoptosis in cancer cells. | POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis.
Yadav S, Zajac E, Singhal SS, Singhal J, Drake K, Awasthi YC, Awasthi S. | 01/21/2010 |
| decreased expression of REPS2 might be a key factor, causing prostate cancer cells to become resistant to induction of apoptosis by androgen deprivation. | Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells.
Penninkhof F, Grootegoed JA, Blok LJ. | 01/21/2010 |