| Effects of the Nonstructural Protein-Nucleolar and Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress. | Effects of the Nonstructural Protein-Nucleolar and Coiled-Body Phosphoprotein 1 Protein Interaction on rRNA Synthesis Through Telomeric Repeat-Binding Factor 2 Regulation Under Nucleolar Stress.
Zhang M, Zeng Y, Wang F, Feng H, Liu Q, Li F, Zhao S, Zhao J, Liu Z, Zheng F, Liu H. | 10/25/2024 |
| T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells. | T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.
Choi H, Kim HD, Choi YW, Lim H, Kim KW, Kim KS, Lee YC, Kim CH. | 11/30/2023 |
| High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer. | High expression of NOLC1 as an independent prognostic factor for survival in patients with colorectal cancer.
Sun Z, Zhang Q, Lv J, Sun Y, Feng Z, Zhang M, Zhang F, Xia C, Gao Y, Zhang Z, Zuo YF, Ren SY., Free PMC Article | 11/6/2023 |
| Roles of NOLC1 in cancers and viral infection. | Roles of NOLC1 in cancers and viral infection.
Zhai F, Wang J, Luo X, Ye M, Jin X. | 08/20/2023 |
| NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and beta-catenin accumulation. | NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and β-catenin accumulation.
Kim W, Yeo DY, Choi SK, Kim HY, Lee SW, Ashim J, Han JE, Yu W, Jeong H, Park JK, Park S. | 11/19/2022 |
| Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings. | Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings.
Luo JH, Liu S, Tao J, Ren BG, Luo K, Chen ZH, Nalesnik M, Cieply K, Ma T, Cheng SY, Chen Q, Michalopoulos GK, Nelson JB, Bhargava R, Zhang J, Ma D, Jarrard D, Pennathur A, Luketich JD, DeFranco DB, Monga SP, Tseng G, Yu YP., Free PMC Article | 07/31/2021 |
| This study suggests that the dynamic distribution of telomerase between Cajal bodies and nucleoplasm uniquely impacts telomere length maintenance and identifies Nopp140 as a novel player in telomere biology. | Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.
Bizarro J, Bhardwaj A, Smith S, Meier UT., Free PMC Article | 06/20/2020 |
| Nucleolar TRF2 attenuated nucleolus stress-induced hepatocellular carcinoma cell-cycle arrest by altering rRNA synthesis via interaction with NOLC1. | Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis.
Yuan F, Xu C, Li G, Tong T., Free PMC Article | 11/30/2019 |
| Identification and validation of NOLC1 might be a promising therapeutic strategy for the management of multidrug resistance of non-small cell lung cancer patients. | Identification and validation of NOLC1 as a potential target for enhancing sensitivity in multidrug resistant non-small cell lung cancer cells.
Huang H, Li T, Chen M, Liu F, Wu H, Wang J, Chen J, Li X., Free PMC Article | 03/9/2019 |
| In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR). | Biophysical characterization of the structural change of Nopp140, an intrinsically disordered protein, in the interaction with CK2α.
Na JH, Lee WK, Kim Y, Jeong C, Song SS, Cha SS, Han KH, Shin YK, Yu YG., Free PMC Article | 06/24/2017 |
| D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1. | Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
Zhu CY, Zheng FL, She XS, Zhao D, Gu Y, Duan YT, Chang AK, Liu HS. | 03/12/2016 |
| pRb2/p130 cytoplasmic delocalization can lead to cell cycle deregulation | pRb2/p130 localizes to the cytoplasm in diffuse gastric cancer.
Cito L, Indovina P, Forte IM, Pentimalli F, Di Marzo D, Somma P, Barone D, Penon A, Penon D, Ceccherini E, Micheli P, Saragoni L, Di Domenico M, Feola A, Roviello F, Mattioli E, Giordano GG, Giordano A. | 04/25/2015 |
| our study demonstrated that DNA methylation is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells, and NOLC1 gene hypermethylation of the four CpG dinucleotides is a potential biomarker for hepatocellular carcinoma. | Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma.
Duan X, Zhang J, Liu S, Zhang M, Wang Q, Cheng J. | 04/12/2014 |
| A Nopp140 fragment (residues 568-596) and inositol hexakisphosphate competitively bind to the catalytic subunit of CK2 (CK2alpha), and phospho-Ser574 of Nopp140 significantly enhances its interaction with CK2alpha. | Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140.
Lee WK, Son SH, Jin BS, Na JH, Kim SY, Kim KH, Kim EE, Yu YG, Lee HH., Free PMC Article | 02/1/2014 |
| H5N1 viral NS1 interacts with host NOLC1 protein. | Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1.
Zhu C, Zheng F, Sun T, Duan Y, Cao J, Feng H, Shang L, Zhu Y, Liu H., Free PMC Article | 09/7/2013 |
| Structural disorder and local order of hNopp140 | Structural disorder and local order of hNopp140.
Tantos A, Szrnka K, Szabo B, Bokor M, Kamasa P, Matus P, Bekesi A, Tompa K, Han KH, Tompa P. | 03/23/2013 |
| The regulation of NOCL1 protein is a critical role for the transcription NF-kB and cAMP response element-bing protein | Identification of nucleolar and coiled-body phosphoprotein 1 (NOLC1) minimal promoter regulated by NF-κB and CREB.
Gao X, Wang Q, Li W, Yang B, Song H, Ju W, Liu S, Cheng J. | 05/7/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| Nopp140 could be a component implicated in the early steps of pre-rRNA processing. | Localization of Nopp140 within mammalian cells during interphase and mitosis.
Thiry M, Cheutin T, Lamaye F, Thelen N, Meier UT, O'Donohue MF, Ploton D., Free PMC Article | 01/21/2010 |
| both NOLC1 and tumor protein 53 work together synergistically to activate the MDM2 promoter in NPC cells. | NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression.
Hwang YC, Lu TY, Huang DY, Kuo YS, Kao CF, Yeh NH, Wu HC, Lin CT., Free PMC Article | 01/21/2010 |
| The functional deficiency in spinal muscular atrophy cells is associated with decreased localization of the snoRNP chaperone Nopp140 in Cajal bodies that correlates with disease severity. | The loss of the snoRNP chaperone Nopp140 from Cajal bodies of patient fibroblasts correlates with the severity of spinal muscular atrophy.
Renvoisé B, Colasse S, Burlet P, Viollet L, Meier UT, Lefebvre S., Free PMC Article | 01/21/2010 |
| InsP(6) specifically binds to CK2alpha and disrupts the interaction between CK2alpha and Nopp140 with an IC(50) value of 25 microM, thereby attenuating the Nopp140-mediated repression of CK2 activity. | Characterization of the InsP6-dependent interaction between CK2 and Nopp140.
Lee WK, Lee SY, Kim WI, Rho YH, Bae YS, Lee C, Kim IY, Yu YG. | 01/21/2010 |
| hNopp140, a scaffold protein, is involved in the nucleolar assembly, fusion, and maintenance | Chromatin tethering effects of hNopp140 are involved in the spatial organization of nucleolus and the rRNA gene transcription.
Tsai YT, Lin CI, Chen HK, Lee KM, Hsu CY, Yang SJ, Yeh NH., Free PMC Article | 01/21/2010 |
| NOPP140 is involved in a PKA signaling pathway that leads to agp activation | Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene.
Chiu CM, Tsay YG, Chang CJ, Lee SC. | 01/21/2010 |
| hNopp140 serves as a negative regulator of CK2 and InsP(6) stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2 | Protein kinase CK2 is inhibited by human nucleolar phosphoprotein p140 in an inositol hexakisphosphate-dependent manner.
Kim YK, Lee KJ, Jeon H, Yu YG. | 01/21/2010 |