| Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism. | Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.
Peckert-Maier K, Wild AB, Sprißler L, Fuchs M, Beck P, Auger JP, Sinner P, Strack A, Mühl-Zürbes P, Ramadan N, Kunz M, Krönke G, Stich L, Steinkasserer A, Royzman D., Free PMC Article | 01/3/2024 |
| Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality. | Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
Holtan SG, Savid-Frontera C, Walton K, Eaton AA, Demorest C, Hoeschen A, Zhang L, Reid K, Kurian T, Sayegh Z, Julia E, Maakaron J, Bachanova V, Jurdi NE, MacMillan ML, Weisdorf DJ, Felices M, Miller JS, Blazar BR, Davila ML, Betts BC., Free PMC Article | 03/16/2023 |
| CD83 Regulates the Immune Responses in Inflammatory Disorders. | CD83 Regulates the Immune Responses in Inflammatory Disorders.
Riaz B, Islam SMS, Ryu HM, Sohn S., Free PMC Article | 02/17/2023 |
| The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis. | The soluble CD83 protein prevents bone destruction by inhibiting the formation of osteoclasts and inducing resolution of inflammation in arthritis.
Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E, Mühl-Zürbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bäuerle T, Nagel L, Schett G, Bozec A, Steinkasserer A., Free PMC Article | 09/3/2022 |
| Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity. | Monocyte Maturation Mediators Upregulate CD83, ICAM-1 and MHC Class 1 Expression on Ewing's Sarcoma, Enhancing T Cell Cytotoxicity.
Biele E, Schober SJ, Prexler C, Thiede M, Heyking KV, Gassmann H, Eck J, Xue B, Burdach S, Thiel U., Free PMC Article | 12/25/2021 |
| Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses. | Soluble CD83 suppresses experimental food allergy via regulating aberrant T helper 2 responses.
Song W, Li H, Jia B, Wang Z, Liu Q, Yang G, Li X. | 08/28/2021 |
| Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses. | Contribution of a European-Prevalent Variant near CD83 and an East Asian-Prevalent Variant near IL17RB to Herpes Zoster Risk in Tofacitinib Treatment: Results of Genome-Wide Association Study Meta-Analyses.
Bing N, Zhou H, Chen X, Hirose T, Kochi Y, Tsuchida Y, Ishigaki K, Sumitomo S, Fujio K, Zhang B, Valdez H, Vincent MS, Martin D, Clark JD., Free PMC Article | 08/14/2021 |
| Difference in Presence and Number of CD83(+) Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease. | Difference in Presence and Number of CD83(+) Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease.
Despalatović BR, Babić M, Bratanić A, Tonkić A, Vilović K., Free PMC Article | 12/12/2020 |
| Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells. | Endogenous Expression of the Human CD83 Attenuates EAE Symptoms in Humanized Transgenic Mice and Increases the Activity of Regulatory T Cells.
Zinser E, Naumann R, Wild AB, Michalski J, Deinzer A, Stich L, Kuhnt C, Steinkasserer A, Knippertz I., Free PMC Article | 10/24/2020 |
| MHC II ubiquitination by E3 ubiquitin-protein ligase MARCH8 (MARCH8) and CD83 antigen (CD83) plays a critical role in T cell thymic selection [Review]. | MARCH ligases in immunity.
Liu H, Mintern JD, Villadangos JA. | 07/11/2020 |
| data establish CD83 as a potential biomarker and therapeutic target in Hodgkin lymphoma. | CD83 is a new potential biomarker and therapeutic target for Hodgkin lymphoma.
Li Z, Ju X, Lee K, Clarke C, Hsu JL, Abadir E, Bryant CE, Pears S, Sunderland N, Heffernan S, Hennessy A, Lo TH, Pietersz GA, Kupresanin F, Fromm PD, Silveira PA, Tsonis C, Cooper WA, Cunningham I, Brown C, Clark GJ, Hart DNJ., Free PMC Article | 07/20/2019 |
| Anti-CD83 may be clinically useful in autoimmunity. | CD83 Antibody Inhibits Human B Cell Responses to Antigen as well as Dendritic Cell-Mediated CD4 T Cell Responses.
Wong KY, Baron R, Seldon TA, Jones ML, Rice AM, Munster DJ. | 04/13/2019 |
| the presence of CD83 in mDC membranes enhances T lymphocyte proliferation by boosting calcium release from intracellular stores in these cells. | Dendritic cell membrane CD83 enhances immune responses by boosting intracellular calcium release in T lymphocytes.
Pinho MP, Migliori IK, Flatow EA, Barbuto JA. | 10/7/2017 |
| this study shows that the tolerogenic mechanism of action of sCD83 to be dependent on initial interaction with antigen-presenting cells, altering early cytokine signal pathways and leading to T cell unresponsiveness | Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14(+) Monocytes.
Horvatinovich JM, Grogan EW, Norris M, Steinkasserer A, Lemos H, Mellor AL, Tcherepanova IY, Nicolette CA, DeBenedette MA., Free PMC Article | 09/16/2017 |
| this study shows differential expression and function of CD83 on human immune cells, and reveals potential new roles for this molecule as a target of therapeutic manipulation in transplantation, inflammation, and autoimmune diseases | The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population.
Ju X, Silveira PA, Hsu WH, Elgundi Z, Alingcastre R, Verma ND, Fromm PD, Hsu JL, Bryant C, Li Z, Kupresanin F, Lo TH, Clarke C, Lee K, McGuire H, Fazekas de St Groth B, Larsen SR, Gibson J, Bradstock KF, Clark GJ, Hart DN. | 08/12/2017 |
| We conducted a genome-wide association study (GWAS) of plasma caffeine, paraxanthine, theophylline, theobromine and paraxanthine/caffeine ratio. A single SNP at 6p23 (near CD83) and several SNPs at 7p21 (near AHR), 15q24 (near CYP1A2) and 19q13.2 (near CYP2A6) met GW-significance (P < 5 x 10-8) and were associated with one or more metabolites | Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.
Cornelis MC, Kacprowski T, Menni C, Gustafsson S, Pivin E, Adamski J, Artati A, Eap CB, Ehret G, Friedrich N, Ganna A, Guessous I, Homuth G, Lind L, Magnusson PK, Mangino M, Pedersen NL, Pietzner M, Suhre K, Völzke H, Swiss Kidney Project on Genes in Hypertension (SKIPOGH) team, Bochud M, Spector TD, Grabe HJ, Ingelsson E. | 06/10/2017 |
| Crystal structure of human CD83 reveals that its surface domain consists of an Ig-like domain only.CD83 exerts its immunological activity by mixed homotypic and heterotypic interactions as typically observed for proteins present in the immunological synapse. | Crystal Structure of the Extracellular Domain of the Human Dendritic Cell Surface Marker CD83.
Heilingloh CS, Klingl S, Egerer-Sieber C, Schmid B, Weiler S, Mühl-Zürbes P, Hofmann J, Stump JD, Sticht H, Kummer M, Steinkasserer A, Muller YA. | 04/29/2017 |
| this study shows that dendritic cells from rheumatoid arthritis patients have low expression levels of CD83 | Maturation and cytokine production potential of dendritic cells isolated from rheumatoid arthritis patients peripheral blood and induced in vitro.
Sennikov SV, Falaleeva SA, Shkaruba NS, Chumasova OA, Obleukhova IA, Sizikov AE, Kurilin VV. | 03/18/2017 |
| Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vgamma9Vdelta2 T cells in low levels of IL-2. | Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vγ9Vδ2 T cells in low levels of IL-2.
Cho HW, Kim SY, Sohn DH, Lee MJ, Park MY, Sohn HJ, Cho HI, Kim TG. | 08/13/2016 |
| nonspreading Rift Valley fever virus infection of monocyte-derived immature denditic cells results in incomplete maturation, associated with gradual downregulation of CD83. | Nonspreading Rift Valley Fever Virus Infection of Human Dendritic Cells Results in Downregulation of CD83 and Full Maturation of Bystander Cells.
Oreshkova N, Wichgers Schreur PJ, Spel L, Vloet RP, Moormann RJ, Boes M, Kortekaas J., Free PMC Article | 06/28/2016 |
| Sustained expression of CD83 was observed when CD4+ T cells were induced by transforming growth factor-beta to differentiate into CD4+CD25+ forkhead box P3+ regulatory T (iTreg) cells. | Continuous expression of CD83 on activated human CD4⁺ T cells is correlated with their differentiation into induced regulatory T cells.
Chen L, Guan S, Zhou Q, Sheng S, Zhong F, Wang Q., Free PMC Article | 05/7/2016 |
| These results suggest that HTLV-I induces CD83 expression on T cells via Tax1 -mediated NF-kappaB activation, which may promote HTLV-I infection in vivo. | Human T-cell leukemia virus type-I Tax induces the expression of CD83 on T cells.
Tanaka Y, Mizuguchi M, Takahashi Y, Fujii H, Tanaka R, Fukushima T, Tomoyose T, Ansari AA, Nakamura M., Free PMC Article | 03/26/2016 |
| CD83(+) T cells share important features with regulatory T cells, identifying CD83 as a novel lineage marker to discriminate between different T cell populations. | Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.
Kreiser S, Eckhardt J, Kuhnt C, Stein M, Krzyzak L, Seitz C, Tucher C, Knippertz I, Becker C, Günther C, Steinkasserer A, Lechmann M. | 08/8/2015 |
| GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation and that this interaction plays a role in CD83 glycosylation as well as in surface expression of CD83 on dendritic cells. | CD83 and GRASP55 interact in human dendritic cells.
Stein MF, Blume K, Heilingloh CS, Kummer M, Biesinger B, Sticht H, Steinkasserer A. | 06/27/2015 |
| suggesting that a negative feedback regulation may exist in monocyte differentiation into dendritic cells (DCs) based on sCD83 released from the mature DCs | Soluble CD83 inhibits human monocyte differentiation into dendritic cells in vitro.
Lin H, Liang S, Zhong Z, Wen J, Li W, Wang L, Xu J, Zhong F, Li X. | 02/21/2015 |