| Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway. | Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.
Wu Y, Zhao B, Chen X, Geng X, Zhang Z. | 04/9/2022 |
| Hsc70 Interacts with beta4GalT5 to Regulate the Growth of Gliomas. | Hsc70 Interacts with β4GalT5 to Regulate the Growth of Gliomas.
Sun G, Cao Y, Dai X, Li M, Guo J. | 10/3/2020 |
| Results demonstrated B4GalT5 downregulation improved insulin resistance by promoting adipogenic commitment and decreasing M1 macrophage infiltration. | Downregulation of β1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.
Li SF, Zhu CS, Wang YM, Xie XX, Xiao LL, Zhang ZC, Tang QQ, Li X., Free PMC Article | 11/30/2019 |
| beta-1,4-GalT-V gene/protein expression is specifically increased in colorectal cancer, compared to visibly normal tissue. Furthermore, we observed a marked increase in its enzymatic activity, and its product lactosylceramide. beta-1,4-GalT-V may serve as a diagnostic and therapeutic biomarker for the progression of colorectal cancer. | Lactosylceramide synthase β-1,4-GalT-V: A novel target for the diagnosis and therapy of human colorectal cancer.
Chatterjee SB, Hou J, Bandaru VVR, Pezhouh MK, Syed Rifat Mannan AA, Sharma R. | 06/8/2019 |
| 2.3-kb 5'-flanking region of the human beta-1,4-GalT V gene was cloned and the region -116/-18 relative to the transcription start site as that having promoter activity. | Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.
Sato T, Furukawa K. | 09/28/2017 |
| B4GALT1 and B4GALT5, two members of B4GALT gene family, are involved in the development of multidrug resistance of human leukemia cells. | B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1.
Zhou H, Ma H, Wei W, Ji D, Song X, Sun J, Zhang J, Jia L., Free PMC Article | 03/1/2014 |
| The expression of the beta-1,4-GalT V gene has been shown to be regulated by transcription factors Sp1 and Ets-1 in cancer cells.(review) | [Regulation of human β-1,4-galactosyltransferase V gene expression in cancer cells].
Sato T, Furukawa K. | 04/13/2013 |
| These data reveal a critical role of beta1,4GalT V in the self-renewal and tumorigenicity of glioma-initiating cells. | Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.
Wei Y, Zhou F, Ge Y, Chen H, Cui C, Li Q, Liu D, Yang Z, Wu G, Sun S, Gu J, Jiang J. | 07/12/2010 |
| sulfated keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST | Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.
Kitayama K, Hayashida Y, Nishida K, Akama TO. | 01/21/2010 |
| Ets-1 enhances expression of the beta-1,4-GalT V gene through activation of the Sp1 gene in cancer cells | Sequential action of Ets-1 and Sp1 in the activation of the human beta-1,4-galactosyltransferase V gene involved in abnormal glycosylation characteristic of cancer cells.
Sato T, Furukawa K. | 01/21/2010 |
| Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line | Over-expression of beta-1,4-galactosyltransferase V increases the growth of astrocytoma cell line.
Xu S, Zhang S, Chen C, Yan J, Cai M, Zhu X, Gu J. | 01/21/2010 |
| results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy | Beta1,4-galactosyltransferase V functions as a positive growth regulator in glioma.
Jiang J, Chen X, Shen J, Wei Y, Wu T, Yang Y, Wang H, Zong H, Yang J, Zhang S, Xie J, Kong X, Liu W, Gu J. | 01/21/2010 |