| Human chorionic gonadotrophin indirectly activates peripheral gammadeltaT cells to produce interleukin-10 during early pregnancy. | Human chorionic gonadotrophin indirectly activates peripheral γδT cells to produce interleukin-10 during early pregnancy.
Li L, Liu Y, Zhou W, Yang C, Feng T, Li H., Free PMC Article | 02/27/2024 |
| Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway by Antagonizing TGF-beta in Giant Cell Tumor of Bone. | Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway by Antagonizing TGF-β in Giant Cell Tumor of Bone.
Xu T, Xu S, Ma G, Chang J, Zhang C, Zhou P, Wang C, Xu P, Yang J, Hu Y, Wu Y., Free PMC Article | 02/6/2024 |
| Associations between nausea and vomiting in pregnancy, disgust sensitivity, and first-trimester maternal serum free beta-hCG and PAPP-A. | Associations between nausea and vomiting in pregnancy, disgust sensitivity, and first-trimester maternal serum free β-hCG and PAPP-A.
Kaňková Š, Hlaváčová J, Roberts K, Benešová J, Havlíček J, Calda P, Dlouhá D, Roberts SC. | 06/7/2023 |
| CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes for Patients with Gastric Cancer. | CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes for Patients with Gastric Cancer.
Ji B, Qiao L, Zhai W. | 03/16/2023 |
| in mole pregnancy, levels at baseline, first, second, and third weeks post-evacuation predict persistent disease | Predictive value of some hematological parameters for non-invasive and invasive mole pregnancies.
Abide Yayla C, Özkaya E, Yenidede I, Eser A, Ergen EB, Tayyar AT, Şentürk MB, Karateke A. | 10/27/2018 |
| Carriage of particular variants in the promoter of the CGB5 gene seems to protect against recurrent miscarriage. | A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage.
Rull K, Christiansen OB, Nagirnaja L, Steffensen R, Margus T, Laan M., Free PMC Article | 07/12/2018 |
| the accumulated data indicate that only mutations with neutral or mild functional consequences might be tolerated in the major hCG-beta genes CGB5 and CGB8. | Structural and functional analysis of rare missense mutations in human chorionic gonadotrophin β-subunit.
Nagirnaja L, Venclovas Č, Rull K, Jonas KC, Peltoketo H, Christiansen OB, Kairys V, Kivi G, Steffensen R, Huhtaniemi IT, Laan M., Free PMC Article | 07/12/2018 |
| carriers of minor alleles of CGB had a reduced risk of recurrent miscarriage | Chorionic gonadotropin beta-gene variants are associated with recurrent miscarriage in two European populations.
Rull K, Nagirnaja L, Ulander VM, Kelgo P, Margus T, Kaare M, Aittomäki K, Laan M., Free PMC Article | 07/12/2018 |
| compared the human (45,165 bp) and chimpanzee (39,876 bp) LHB/CGB regions and hereby present evidence for structural variation resulting in discordant number of CGB genes (6 in human, 5 in chimpanzee) | High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes.
Hallast P, Saarela J, Palotie A, Laan M., Free PMC Article | 07/12/2018 |
| Data indicate the diagnostic criteria of chorionic gonadotropin beta subunit (beta-hCG) and alpha-Fetoprotein (alphaFP) in CSF and serum, which may advance the early and formal diagnosis of intracranial germ cell tumors (ICGCTs). | An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors.
Hu M, Guan H, Lau CC, Terashima K, Jin Z, Cui L, Wang Y, Li G, Yao Y, Guo Y, Li YM, Zhong D, Xiao J, Wan X, Lian X, Feng F, Ren H, Zhao Y, Cheng X, Gu F., Free PMC Article | 10/22/2016 |
| Genetic variation within the CGB5 gene is associated with recurrent spontaneous abortion risk in Chinese women. | Association of rs7260002 of chorionic gonadotrophin β5 with idiopathic recurrent spontaneous abortion in Chinese population.
Sun Y, Ji X., Free PMC Article | 10/24/2015 |
| TGF-beta enhances hCG-beta expression in glioblastoma. | TGF-β-induced hCG-β regulates redox homeostasis in glioma cells.
Ahmad F, Ghosh S, Sinha S, Joshi SD, Mehta VS, Sen E. | 08/22/2015 |
| This study showed a link between low maternal serum hCG levels and cryptorchidism in boys from uncomplicated pregnancy. | Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study.
Chedane C, Puissant H, Weil D, Rouleau S, Coutant R., Free PMC Article | 04/18/2015 |
| Elevated serum human chorionic gonadotropin is associated with germ-cell tumours. | Personalised chemotherapy based on tumour marker decline in poor prognosis germ-cell tumours (GETUG 13): a phase 3, multicentre, randomised trial.
Fizazi K, Pagliaro L, Laplanche A, Fléchon A, Mardiak J, Geoffrois L, Kerbrat P, Chevreau C, Delva R, Rolland F, Theodore C, Roubaud G, Gravis G, Eymard JC, Malhaire JP, Linassier C, Habibian M, Martin AL, Journeau F, Reckova M, Logothetis C, Culine S., Free PMC Article | 03/7/2015 |
| The effect of human chorionic gonadotropin (hCG), an LH receptor agonist, on APP beta-cleavage in the SH-SY5Y neuroblastoma cell line. | Human chorionic gonadotropin increases β-cleavage of amyloid precursor protein in SH-SY5Y cells.
Saberi S, Du YP, Christie M, Goldsbury C. | 05/31/2014 |
| Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia. | MTA3 regulates CGB5 and Snail genes in trophoblast.
Chen Y, Miyazaki J, Nishizawa H, Kurahashi H, Leach R, Wang K., Free PMC Article | 06/15/2013 |
| Serum hCG concentrations were negatively associated with maternal prepregnancy body mass index. | Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy.
Eskild A, Fedorcsak P, Mørkrid L, Tanbo TG. | 12/22/2012 |
| PGDH activity was low before the ovulatory hCG stimulus, peaked 12-24 h after hCG, and was low again 36 h after hCG administration. | Prostaglandin dehydrogenase (PGDH) in granulosa cells of primate periovulatory follicles is regulated by the ovulatory gonadotropin surge via multiple G proteins.
Duffy DM., Free PMC Article | 06/18/2011 |
| Our finding may represent a novel methylation allelic polymorphism or gain of imprinting in CGB5 promoter leading to expressional silencing of paternal alleles and increasing susceptibility to pregnancy loss. | Methylation allelic polymorphism (MAP) in chorionic gonadotropin beta5 (CGB5) and its association with pregnancy success.
Uusküla L, Rull K, Nagirnaja L, Laan M., Free PMC Article | 02/5/2011 |
| Monochorionic twins have a significantly lower serum free beta-hCG (beta human chorionic gonadotropin) and a significantly lower PAPP-A(pregnancy-associated plasma protein A) compared to dichorionic | Early first-trimester free beta-hCG and PAPP-A serum distributions in monochorionic and dichorionic twins.
Linskens IH, Spreeuwenberg MD, Blankenstein MA, van Vugt JM. | 01/21/2010 |
| hCGbeta V79M polymorphism is absent or extremely rare in Mexican Mestizo women. | No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women.
Dominguez-Lopez P, Diaz-Cueto L, Ulloa-Aguirre A, Lopez-Valle MA, Arechavaleta-Velasco F. | 01/21/2010 |
| Three single nucleotide polymorphisms in CGB5 and CSH1 genes were genotyped for 844 offspring of the cases and controls. Maternal breast cancer risk did not significantly differ by the offspring's carrier status of the three SNPs. | Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk.
Chen Y, Kibriya MG, Jasmine F, Santella RM, Senie RT, Ahsan H, Chen Y, Kibriya MG, Jasmine F, Santella RM, Senie RT, Ahsan H., Free PMC Articles: PMC2779753, PMC2779753 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.
Hanna CW, Bretherick KL, Liu CC, Stephenson MD, Robinson WP. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk.
Chen Y, Kibriya MG, Jasmine F, Santella RM, Senie RT, Ahsan H, Chen Y, Kibriya MG, Jasmine F, Santella RM, Senie RT, Ahsan H. | 01/11/2009 |
| Observational study of genotype prevalence. (HuGE Navigator) | Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations.
Jiang M, Savontaus ML, Simonsen H, Williamson C, Müllenbach R, Gromoll J, Terwort N, Alevizaki M, Huhtaniemi I. | 03/13/2008 |
| hCG up-regulating wnt7b and wnt5b could contribute to pregnancy-induced breast cancer in humans | Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.
Kuorelahti A, Rulli S, Huhtaniemi I, Poutanen M. | 01/21/2010 |