| Immp2l Deficiency Induced Granulosa Cell Senescence Through STAT1/ATF4 Mediated UPR[mt] and STAT1/(ATF4)/HIF1alpha/BNIP3 Mediated Mitophagy: Prevented by Enocyanin. | Immp2l Deficiency Induced Granulosa Cell Senescence Through STAT1/ATF4 Mediated UPR(mt) and STAT1/(ATF4)/HIF1α/BNIP3 Mediated Mitophagy: Prevented by Enocyanin.
Qu X, Pan P, Cao S, Ma Y, Yang J, Gao H, Pei X, Yang Y., Free PMC Article | 11/5/2024 |
| Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase. | Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase.
Clarke RA, Govindaraju H, Beretta M, Olzomer E, Lawther AJ, Walker AK, Fang Z, Eapen V, Hyams TC, Killingsworth M, Bridge W, Turner N, Siddiqui KS., Free PMC Article | 02/1/2024 |
| Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse. | Antioxidant Behavioural Phenotype in the Immp2l Gene Knock-Out Mouse.
Lawther AJ, Zieba J, Fang Z, Furlong TM, Conn I, Govindaraju H, Choong LLY, Turner N, Siddiqui KS, Bridge W, Merlin S, Hyams TC, Killingsworth M, Eapen V, Clarke RA, Walker AK., Free PMC Article | 10/6/2023 |
| Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder. | Immp2l knockdown in male mice increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a model of Tourette syndrome and autism spectrum disorder.
Leung BK, Merlin S, Walker AK, Lawther AJ, Paxinos G, Eapen V, Clarke R, Balleine BW, Furlong TM. | 08/16/2023 |
| Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice. | Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice.
Ma Y, Liang RM, Ma N, Mi XJ, Cheng ZY, Zhang ZJ, Lu BS, Li PA. | 06/24/2023 |
| Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage. | Human T2D-Associated Gene IMP2/IGF2BP2 Promotes the Commitment of Mesenchymal Stem Cells Into Adipogenic Lineage.
Regué L, Wang W, Ji F, Avruch J, Wang H, Dai N., Free PMC Article | 12/31/2022 |
| LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis. | LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y., Free PMC Article | 11/26/2022 |
| [IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice]. | [IMMP2L gene mutation activates mitochondrial apoptotic pathway to aggravate cerebral ischemic injury in mice].
Cheng Z, Mi X, Zhang Z, Ma Y. | 07/10/2021 |
| The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/beta-Catenin-Estrogen Pathway: Preventive Effect of Melatonin. | The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
He Q, Gu L, Lin Q, Ma Y, Liu C, Pei X, Li PA, Yang Y. | 01/9/2021 |
| IMP2-deficient muscle exhibits reduced fatty acid oxidation, due to a reduced abundance of mRNA of peroxisome proliferator-activated receptor alpha (PPARalpha), an IMP2 client, and PPARalpha protein. IMP2-deficient muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exercise, exhibit reduced oxygen consumption from fatty acids, with higher oxygen consumption from glucose. | IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.
Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J., Free PMC Article | 11/9/2019 |
| Data indicates that overexpression of IMP2 alters the regulatory capacity of many miRNAs and conclude that IMP2 competes with miRNAs for binding sites on thousands of transcripts. As a result, data implicates that overexpression of IMP2 has distinct effects to the regulatory capacity of miRNAs with yet unknown consequences for translational efficiency. | Transgenic expression of the RNA binding protein IMP2 stabilizes miRNA targets in murine microsteatosis.
Dehghani Amirabad A, Ramasamy P, Wierz M, Nordström K, Kessler SM, Schulz MH, Simon M. | 05/25/2019 |
| The results indicate that IMP2 deficiency delayed bone remodeling by significantly inhibiting the activity of osteoclasts and impairing their adhesion. | Histochemical evidence of IGF2 mRNA-binding protein 2-mediated regulation of osteoclast function and adhesive ability.
Liu H, Li D, Liu S, Liu Z, Li M. | 05/19/2018 |
| data suggest that respiratory deficiency is not the cause of the observed Immp2l mutant phenotypes. | Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice.
Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B., Free PMC Article | 01/13/2018 |
| provides evidence for a causal role of oxidative stress in neurodegeneration of Immp2l mutant mice | The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment.
Liu C, Li X, Lu B., Free PMC Article | 10/29/2016 |
| IMP2 as a developmental stage-dependent regulator of the differentiation potentials of NPCs in the mouse neocortex. | IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells.
Fujii Y, Kishi Y, Gotoh Y. | 06/29/2013 |
| This study demomistrated that Immp2l deficiency increases ischemic brain damage by enhancing O(2)(-) production and damaging mitochondrial functional performance. | Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function.
Ma Y, Mehta SL, Lu B, Li PA., Free PMC Article | 02/11/2012 |
| Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal | Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal.
George SK, Jiao Y, Bishop CE, Lu B., Free PMC Article | 12/17/2011 |