| Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation. | Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation.
Lu J, Zhang J, Jiang H, Hu Z, Zhang Y, He L, Yang J, Xie Y, Wu D, Li H, Zeng K, Tan P, Xiao Q, Song Z, Pan C, Bai X, Yu X., Free PMC Article | 11/6/2024 |
| Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex. | Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex.
Paramore SV, Goodwin K, Fowler EW, Devenport D, Nelson CM., | 09/11/2024 |
| Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree. | Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
Raab M, Christodoulou E, Krishnankutty R, Gradinaru A, Walker AD, Olaizola P, Younger NT, Lyons AM, Jarman EJ, Gournopanos K, von Kriegsheim A, Waddell SH, Boulter L. | 07/10/2024 |
| Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation. | Vangl-dependent mesenchymal thinning shapes the distal lung during murine sacculation.
Paramore SV, Trenado-Yuste C, Sharan R, Nelson CM, Devenport D., | 06/5/2024 |
| VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation. | VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for autophagic degradation.
Hu Z, Xie Y, Lu J, Yang J, Zhang J, Jiang H, Li H, Zhang Y, Wu D, Zeng K, Bai X, Yu X., Free PMC Article | 06/30/2023 |
| An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation. | An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation.
Kim YS, Yuan J, Dewar A, Borg JP, Threadgill DW, Sun X, Dey SK., Free PMC Article | 05/12/2023 |
| Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium. | Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
Nagaoka T, Katsuno T, Fujimura K, Tsuchida K, Kishi M., Free PMC Article | 03/10/2023 |
| Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension. | Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension.
Nychyk O, Galea GL, Molè M, Savery D, Greene NDE, Stanier P, Copp AJ., Free PMC Article | 07/16/2022 |
| The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK. | The cell polarity protein Vangl2 in the muscle shapes the neuromuscular synapse by binding to and regulating the tyrosine kinase MuSK.
Boëx M, Cottin S, Halliez M, Bauché S, Buon C, Sans N, Montcouquiol M, Molgó J, Amar M, Ferry A, Lemaitre M, Rouche A, Langui D, Baskaran A, Fontaine B, Messéant J, Strochlic L. | 05/28/2022 |
| Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. | Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth.
Dos-Santos Carvalho S, Moreau MM, Hien YE, Garcia M, Aubailly N, Henderson DJ, Studer V, Sans N, Thoumine O, Montcouquiol M., Free PMC Article | 08/28/2021 |
| Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-kappaB pathway in chondrocytes. | Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes.
Zhang K, Li Z, Lu Y, Xiang L, Sun J, Zhang H., Free PMC Article | 08/7/2021 |
| Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion. | Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion.
Robert BJA, Moreau MM, Dos Santos Carvalho S, Barthet G, Racca C, Bhouri M, Quiedeville A, Garret M, Atchama B, Al Abed AS, Guette C, Henderson DJ, Desmedt A, Mulle C, Marighetto A, Montcouquiol M, Sans N., Free PMC Article | 05/22/2021 |
| Vangl2 promotes the formation of long cytonemes to enable distant Wnt/beta-catenin signaling. | Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling.
Brunt L, Greicius G, Rogers S, Evans BD, Virshup DM, Wedgwood KCA, Scholpp S., Free PMC Article | 04/17/2021 |
| Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea. | Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.
Najarro EH, Huang J, Jacobo A, Quiruz LA, Grillet N, Cheng AG., Free PMC Article | 04/13/2021 |
| A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. | A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis.
Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT., Free PMC Article | 03/20/2021 |
| Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice. | Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice.
Galea GL, Maniou E, Edwards TJ, Marshall AR, Ampartzidis I, Greene NDE, Copp AJ., Free PMC Article | 03/13/2021 |
| VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. | VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.
Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L., Free PMC Article | 10/31/2020 |
| role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys | Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys.
Derish I, Lee JKH, Wong-King-Cheong M, Babayeva S, Caplan J, Leung V, Shahinian C, Gravel M, Deans MR, Gros P, Torban E., Free PMC Article | 07/4/2020 |
| We demonstrate using mice that Fzd3 and Fzd6 similarly regulate axon turning, are functionally redundant with each other, and that Fzd3 genetically interacts with Vangl2 to guide this process | Frizzled3 and Frizzled6 Cooperate with Vangl2 to Direct Cochlear Innervation by Type II Spiral Ganglion Neurons.
Ghimire SR, Deans MR., Free PMC Article | 07/4/2020 |
| Vangl2 membrane localization within the cochlea is greatly reduced in AP-3-deficient mocha mice, which exhibit profound hearing loss. | Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear.
Tower-Gilchrist C, Zlatic SA, Yu D, Chang Q, Wu H, Lin X, Faundez V, Chen P., Free PMC Article | 05/16/2020 |
| Knock-down of the Vangl2 gene resulted in partial loss of the epithelial basement membrane in the cornea and slowed cell migration. | The core planar cell polarity gene, Vangl2, maintains apical-basal organisation of the corneal epithelium.
Panzica DA, Findlay AS, van Ladesteijn R, Collinson JM., Free PMC Article | 04/4/2020 |
| Vangl2 modulates glomerular injury, at least in part by acting as a brake on MMP9, a potentially harmful endogenous enzyme. | Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury.
Papakrivopoulou E, Vasilopoulou E, Lindenmeyer MT, Pacheco S, Brzóska HŁ, Price KL, Kolatsi-Joannou M, White KE, Henderson DJ, Dean CH, Cohen CD, Salama AD, Woolf AS, Long DA., Free PMC Article | 10/26/2019 |
| Vangl2 mutations significantly reduced trabecular bone mass and distal tibial cortical thickness. | Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Orriss IR, Lanham S, Savery D, Greene NDE, Stanier P, Oreffo R, Copp AJ, Galea GL., Free PMC Article | 09/21/2019 |
| we observed a striking additive genetic interaction between Grhl2 and Grhl3 gain-of-function alleles. moderate Grhl3 overexpression also interacted with the Vangl2Lp allele to cause SB, demonstrating genetic interaction with the planar cell polarity signalling pathway that is implicated in mouse and human neural tube defects. | Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.
De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE., Free PMC Article | 05/11/2019 |
| Studies indicate that mouse developing tooth required VANGL planar cell polarity 2 protein (Vangl2) at an early step of its morphogenetic program [Review]. | The planar cell polarity Vangl2 protein: From genetics to cellular and molecular functions.
Bailly E, Walton A, Borg JP. | 02/2/2019 |