| Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout. | Examining the Association of Rare Allelic Variants in Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and Gout.
Vávra J, Pavelcová K, Mašínová J, Hasíková L, Bubeníková E, Urbanová A, Mančíková A, Stibůrková B., Free PMC Article | 02/15/2024 |
| Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10. | Functional coupling of organic anion transporter OAT10 (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1) influencing the transport function of OAT10.
Ohtsu N, Ohgaki R, Jin C, Xu M, Okanishi H, Takahashi R, Matsui A, Kishimoto W, Ishiguro N, Kanai Y. | 08/13/2022 |
| Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. | Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter.
Shinoda Y, Yamashiro T, Hosooka A, Yasujima T, Yuasa H. | 03/19/2022 |
| A dysfunctional missense variant of OAT10 decreases both gout risk and serum uric acid levels, suggesting OAT10 to be physiologically involved in urate reabsorption in the human kidney. | Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels.
Higashino T, Morimoto K, Nakaoka H, Toyoda Y, Kawamura Y, Shimizu S, Nakamura T, Hosomichi K, Nakayama A, Ooyama K, Ooyama H, Shimizu T, Ueno M, Ito T, Tamura T, Naito M, Nakashima H, Kawaguchi M, Takao M, Kawai Y, Osada N, Ichida K, Yamamoto K, Suzuki H, Shinomiya N, Inoue I, Takada T, Matsuo H., Free PMC Article | 04/25/2020 |
| An adenovirus expressing ORCTL3 leads to growth inhibition of renal tumours in vivo and to substantial destruction of patients' kidney tumour cells ex vivo | The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis.
AbuAli G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang MS, Qize D, Harding SV, Al-Rubaish A, Alzahrani AJ, Al-Ali A, Sanders TA, Aboagye EO, Grimm S., Free PMC Article | 06/6/2015 |
| Since ORCTL3 targets fatty acid metabolism in transformed cells and induces an ER stress specifically in these cells, it reveals a novel therapeutic interference option for tumor cells. | Isolation and characterization of the anticancer gene organic cation transporter like-3 (ORCTL3).
AbuAli G, Grimm S. | 11/22/2014 |
| Expression of SLC22A13 stimulates efflux of aspartate and glutamate at the basolateral membrane in renal collecting duct. | SLC22A13 catalyses unidirectional efflux of aspartate and glutamate at the basolateral membrane of type A intercalated cells in the renal collecting duct.
Schulz C, Fork C, Bauer T, Golz S, Geerts A, Schömig E, Gründemann D. | 03/1/2014 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
Tzvetkov MV, Vormfelde SV, Balen D, Meineke I, Schmidt T, Sehrt D, Sabolić I, Koepsell H, Brockmöller J. | 08/12/2009 |
| ORCTL3 protein causes cell death in v-src-transformed cells and in various human tumor cell lines but not in normal cells or untransformed cell lines. | Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.
Irshad S, Mahul-Mellier AL, Kassouf N, Lemarie A, Grimm S., Free PMC Article | 01/21/2010 |
| SLC22A13 is a new urate and high affinity nicotinate transporter | Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).
Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G. | 01/21/2010 |