| SELENOF is a new tumor suppressor in breast cancer. | SELENOF is a new tumor suppressor in breast cancer.
Zigrossi A, Hong LK, Ekyalongo RC, Cruz-Alvarez C, Gornick E, Diamond AM, Kastrati I. | 08/8/2024 |
| Distinct Roles of SELENOF in Different Human Cancers. | Distinct Roles of SELENOF in Different Human Cancers.
Flowers B, Bochnacka O, Poles A, Diamond AM, Kastrati I., Free PMC Article | 04/1/2023 |
| Role of SELENBP1 and SELENOF in prostate cancer bioenergetics. | Role of SELENBP1 and SELENOF in prostate cancer bioenergetics.
Bera S, Diamond AM. | 12/3/2022 |
| One-Pot Chemical Protein Synthesis Utilizing Fmoc-Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F. | One-Pot Chemical Protein Synthesis Utilizing Fmoc-Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F.
Zhao Z, Mousa R, Metanis N., Free PMC Article | 07/2/2022 |
| Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells. | Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells.
Hong LK, Kadkol S, Sverdlov M, Kastrati I, Elhodaky M, Deaton R, Sfanos KS, Wang H, Liu L, Diamond AM., Free PMC Article | 01/22/2022 |
| Association of the selenoprotein 15-kDa (SEP15) polymorphisms with cancer risk: a meta-analysis. | Association of the selenoprotein 15-kDa (SEP15) polymorphisms with cancer risk: a meta-analysis.
Pabalan N, Tharabenjasin P, Natphopsuk S, Ekaratcharoenchai N, Jarjanazi H. | 07/3/2021 |
| The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway. | The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease.
Wu R, Zhang R, Xiong Y, Sun W, Li Y, Yang X, Liu J, Jiang Y, Guo H, Mo X, Cao J. | 02/22/2020 |
| this work has provided experimental data for the molecular mechanism of SELENOF gene regulation, as well as uncovered the involvement of HSF1 in selenotranscriptomic for the first time. | Transcriptional Regulation of Selenoprotein F by Heat Shock Factor 1 during Selenium Supplementation and Stress Response.
Ren B, Huang Y, Zou C, Wu Y, Huang Y, Ni J, Tian J., Free PMC Article | 01/11/2020 |
| The study suggests the possible importance of SEPP1 rs3877899 and SEP15 rs5859 polymorphisms in susceptibility to breast cancer. | SEPP1 and SEP15 gene polymorphisms and susceptibility to breast cancer.
Mohammaddoust S, Salehi Z, Saeidi Saedi H. | 08/10/2019 |
| Results indicate an interaction between selenium status and selenoprotein genotypes that may contribute to the disparity in prostate cancer incidence and outcome experienced by African Americans | Correlations of SELENOF and SELENOP genotypes with serum selenium levels and prostate cancer.
Ekoue DN, Ansong E, Liu L, Macias V, Deaton R, Lacher C, Picklo M, Nonn L, Gann PH, Kajdacsy-Balla A, Prins GS, Freeman VL, Diamond AM., Free PMC Article | 02/2/2019 |
| The allelic and genotypic frequencies did not differ between rapid and nonrapid progressors; however, the presence of the AA genotype of the rs5859 polymorphism was associated with a shorter time of progression to AIDS compared with GG homozygotes (hazard ratio = 3.62, 95% CI = 1.55-8.43, p = 0.003). | Role of SEP15 Gene Polymorphisms in the Time of Progression to AIDS.
Benelli JL, de Medeiros RM, Matte MC, de Melo MG, de Matos Almeida SE, Fiegenbaum M. | 04/8/2017 |
| Genotype variation within the 3'-UTR of the SEP 15 gene showed no association with breast cancer risk or clinico-pathological parameters in Caucasian women. | The 811 C/T polymorphism in the 3' untranslated region of the selenoprotein 15-kDa (Sep15) gene and breast cancer in Caucasian women.
Watrowski R, Castillo-Tong DC, Fabjani G, Schuster E, Fischer M, Zeillinger R. | 02/18/2017 |
| Results suggest that SEP15 plays important roles in the regulation of the G1 phase during the cell cycle as well as in cell motility of Chang liver cells offering a novel functional link between the cell cycle and cell motility. | Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells.
Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ., Free PMC Article | 03/19/2016 |
| Concerning rs561104, the serum selenium concentration was higher in CC homozygotes (5.65 +/- 1.11 mug/dL) compared with T carriers (4.88 +/- 1.25 mug/dL, P = .044). | SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults.
da Rocha TJ, Korb C, Schuch JB, Bamberg DP, de Andrade FM, Fiegenbaum M. | 05/30/2015 |
| Sep15 in Chang liver cells regulates the pathway that antagonizes RhoA/ROCK/MLC-dependent non-apoptotic bleb formation. | Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.
Bang J, Jang M, Huh JH, Na JW, Shim M, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ., Free PMC Article | 04/25/2015 |
| This study provides evidence that SEP15 genetic variation may influence prostate cancer mortality | A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival.
Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J, Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J., Free PMC Articles: PMC2865569, PMC2865569 | 08/2/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (6) articlesPolymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer.
Sutherland A, Kim DH, Relton C, Ahn YO, Hesketh J. A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival.
Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J, Penney KL, Schumacher FR, Li H, Kraft P, Morris JS, Kurth T, Mucci LA, Hunter DJ, Kantoff PW, Stampfer MJ, Ma J. Genetic variants in selenoprotein genes increase risk of colorectal cancer.
Méplan C, Hughes DJ, Pardini B, Naccarati A, Soucek P, Vodickova L, Hlavatá I, Vrána D, Vodicka P, Hesketh JE. Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. | 09/24/2008 |
| It appears that those with the Sep15 1125 AA genotype may benefit most from a higher Se intake, whereas in those with the GG or GA genotype, a higher Se status may increase the risk for lung cancer. | Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism.
Jablonska E, Gromadzinska J, Sobala W, Reszka E, Wasowicz W, Jablonska E, Gromadzinska J, Sobala W, Reszka E, Wasowicz W. | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (4) articlesSingle nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadié M, Foretová L, Cocco P, González-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.
Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Akesson B, Rohrmann S, Linseisen J. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q. Lung cancer risk associated with selenium status is modified in smoking individuals by Sep15 polymorphism.
Jablonska E, Gromadzinska J, Sobala W, Reszka E, Wasowicz W, Jablonska E, Gromadzinska J, Sobala W, Reszka E, Wasowicz W. | 04/3/2008 |
| Genetic and functional analysis of mammalian Sep15 selenoprotein. | Genetic and functional analysis of mammalian Sep15 selenoprotein.
Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL. | 01/21/2010 |
| SEP15, encoding a 15-kDa selenium-containing protein was shown to be downregulated in approximately 60% of MM cell lines and tumor specimens. A SEP15 polymorphic variant, 1125A, resides in the SECIS recognition element | Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype.
Apostolou S, Klein JO, Mitsuuchi Y, Shetler JN, Poulikakos PI, Jhanwar SC, Kruger WD, Testa JR. | 01/21/2010 |
| Studies in mouse show that Sep15 may have redox function. | [Redox reactions of Sep15 and its relationship with tumor development].
Wu HJ, Lin C, Zha YY, Yang JG, Zhang MC, Zhang XY, Liang X, Fu M, Wu M. | 02/19/2004 |