| p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP. | p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP.
Ouyang H, Wu S, Li W, Grey MJ, Wu W, Hansen SH., Free PMC Article | 01/5/2024 |
| Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD. | Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD.
Gallego-Gutiérrez H, González-González L, Ramírez-Martínez L, López-Bayghen E, González-Mariscal L., Free PMC Article | 12/25/2021 |
| TJP2 hepatobiliary disorders: Novel variants and clinical diversity. | TJP2 hepatobiliary disorders: Novel variants and clinical diversity.
Zhang J, Liu LL, Gong JY, Hao CZ, Qiu YL, Lu Y, Feng JY, Li JQ, Li ZD, Wang MX, Xing QH, Knisely AS, Wang JS. | 07/24/2021 |
| New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report. | New tight junction protein 2 variant causing progressive familial intrahepatic cholestasis type 4 in adults: A case report.
Wei CS, Becher N, Friis JB, Ott P, Vogel I, Grønbæk H., Free PMC Article | 11/28/2020 |
| Supra-molecular assembly and positioning of tight junctions as continuous networks of adhesion strands are dependent on the membrane-associated scaffolding proteins ZO1 and ZO2. | Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions.
Beutel O, Maraspini R, Pombo-García K, Martin-Lemaitre C, Honigmann A. | 05/30/2020 |
| It is a potential target of miR-543. | miR-543 promoted the cell proliferation and invasion of nasopharyngeal carcinoma by targeting the JAM-A.
Jiang X, Dai B, Feng L. | 02/29/2020 |
| Results suggested that a reduction in CLDN18-dependent ZO-2 expression enhances MMP2 expression in lung adenocarcinoma cells, resulting in the promotion of the cell migration. | ZO-2 Suppresses Cell Migration Mediated by a Reduction in Matrix Metalloproteinase 2 in Claudin-18-Expressing Lung Adenocarcinoma A549 Cells.
Akizuki R, Eguchi H, Endo S, Matsunaga T, Ikari A. | 07/13/2019 |
| Mutations in the genes responsible for PFIC may be involved in both young and adults with cryptogenic cholestasis in a considerable number of cases, including in heterozygous status. | Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing.
Vitale G, Gitto S, Raimondi F, Mattiaccio A, Mantovani V, Vukotic R, D'Errico A, Seri M, Russell RB, Andreone P. | 06/15/2019 |
| Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS | Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse.
Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I. | 04/7/2018 |
| A likely causal mutation was identified in the majority (61%), spanning many genes including ones that have only rarely been reported to cause cholestatic liver disease, e.g. TJP2 and VIPAS39 | Genetic profiling of children with advanced cholestatic liver disease.
Shagrani M, Burkholder J, Broering D, Abouelhoda M, Faquih T, El-Kalioby M, Subhani SN, Goljan E, Albar R, Monies D, Mazhar N, AlAbdulaziz BS, Abdelrahman KA, Altassan N, Alkuraya FS. | 03/17/2018 |
| Patients with a confirmed ABCB11 or tight junction protein 2 gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 mutation had an elevated THBA proportion (7.51-37.26%). | Prognostic roles of tetrahydroxy bile acids in infantile intrahepatic cholestasis.
Lee CS, Kimura A, Wu JF, Ni YH, Hsu HY, Chang MH, Nittono H, Chen HL., Free PMC Article | 09/2/2017 |
| Studies indicate the modular and supramodular organization of zonula occludens protein 2 (ZO-2) that allows it to interact with a wide variety of molecules, including cell-cell adhesion proteins, cytoskeletal components, and nuclear factors. | ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis, and cell size regulation.
González-Mariscal L, Miranda J, Raya-Sandino A, Domínguez-Calderón A, Cuellar-Perez F. | 08/26/2017 |
| Data identified two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment. | Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment.
Wang HY, Zhao YL, Liu Q, Yuan H, Gao Y, Lan L, Yu L, Wang DY, Guan J, Wang QJ., Free PMC Article | 12/17/2016 |
| TJP2 deficiency may predispose to hepatocellular carcinoma in early childhood | Hepatocellular carcinoma associated with tight-junction protein 2 deficiency.
Zhou S, Hertel PM, Finegold MJ, Wang L, Kerkar N, Wang J, Wong LJ, Plon SE, Sambrotta M, Foskett P, Niu Z, Thompson RJ, Knisely AS., Free PMC Article | 12/17/2016 |
| Claudin-19, the most abundant claudin in myelin, exhibited no binding to ZO2. | Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ₁ domain of zonula occludens.
Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J., Free PMC Article | 06/27/2015 |
| JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. | JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA., Free PMC Article | 09/27/2014 |
| Protein-truncating mutations in the tight junction protein 2 gene cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease. | Mutations in TJP2 cause progressive cholestatic liver disease.
Sambrotta M, Strautnieks S, Papouli E, Rushton P, Clark BE, Parry DA, Logan CV, Newbury LJ, Kamath BM, Ling S, Grammatikopoulos T, Wagner BE, Magee JC, Sokol RJ, Mieli-Vergani G, University of Washington Center for Mendelian Genomics, Smith JD, Johnson CA, McClean P, Simpson MA, Knisely AS, Bull LN, Thompson RJ., Free PMC Article | 05/24/2014 |
| demonstrated that ZO-2 inhibition increases invasive and migrative capacities of invasive tumor cells. This was associated with an increase of MT1-MMP | Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.
Luczka E, Syne L, Nawrocki-Raby B, Kileztky C, Hunziker W, Birembaut P, Gilles C, Polette M. | 01/18/2014 |
| the Alu-related transcript of TJP2 gene (TJP2-Alu transcript) was differentially expressed between colorectal tumor and normal tissues; potential diagnostic markers for colorectal cancer. | Alu-related transcript of TJP2 gene as a marker for colorectal cancer.
Kim YJ, Jung YD, Kim TO, Kim HS. | 10/19/2013 |
| ZO-2 inhibits the Wnt signaling pathway, reduces cell proliferation, and promotes apoptosis; its absence, mutation, or overexpression is present in various human diseases, including deafness and cancer. | ZO-2, a tight junction scaffold protein involved in the regulation of cell proliferation and apoptosis.
Gonzalez-Mariscal L, Bautista P, Lechuga S, Quiros M. | 11/24/2012 |
| AmotL1 and ZO-2 are two candidates that could be harnessed to control the oncogenic function of YAP. | Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.
Oka T, Schmitt AP, Sudol M. | 02/25/2012 |
| these findings imply involvement of the ZO-2 tight junction independent signaling complex containing Jak1 and uPAR in VSMC intercellular communications. | The tight junction protein ZO-2 and Janus kinase 1 mediate intercellular communications in vascular smooth muscle cells.
Tkachuk N, Tkachuk S, Patecki M, Kusch A, Korenbaum E, Haller H, Dumler I. | 09/17/2011 |
| ZO-2 interacts with YAP2 to form complex; ZO-2 facilitates both nuclear translocation of YAP2 & pro-apoptotic function of YAP2; YAP2/ZO-2 complex appears to be involved in cell detachment | Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling.
Oka T, Remue E, Meerschaert K, Vanloo B, Boucherie C, Gfeller D, Bader GD, Sidhu SS, Vandekerckhove J, Gettemans J, Sudol M. | 01/8/2011 |
| The identification of ZASP helps to unfold the complex nuclear molecular arrays that form on ZO-2 scaffolds. | Identification of ZASP, a novel protein associated to Zona occludens-2.
Lechuga S, Alarcón L, Solano J, Huerta M, Lopez-Bayghen E, González-Mariscal L. | 11/13/2010 |
| the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ | TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner.
Remue E, Meerschaert K, Oka T, Boucherie C, Vandekerckhove J, Sudol M, Gettemans J. | 10/30/2010 |