| PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation. | PRDX6 alleviated heart failure by inhibiting doxorubicin-induced ferroptosis through the JAK2/STAT1 pathway inactivation.
Xiong J, Zhou R, Deng X. | 05/28/2024 |
| PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARalpha Activation in Rats Fed High-Fat Diet. | PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet.
Shen W, Yang L, Yang Y, Wang P, Tao X, Shen Y, Wang S, Shen Y. | 06/2/2023 |
| PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma. | PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.
Li H, Wu Z, Zhong R, Zhang Q, Chen Q, Shen Y., Free PMC Article | 10/15/2022 |
| Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy. | Knocking Down Peroxiredoxin 6 Aggravates Cerebral Ischemia-Reperfusion Injury by Enhancing Mitophagy.
Hong T, Zhou Y, Peng L, Wu X, Li Y, Li Y, Zhao Y. | 03/5/2022 |
| Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway. | Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway.
Tang B, Ni W, Zhou J, Ling Y, Niu D, Lu X, Chen T, Ramalingam M, Hu J. | 03/5/2022 |
| Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury. | Regulation of Prdx6 by Nrf2 Mediated Through aiPLA2 in White Matter Reperfusion Injury.
Daverey A, Agrawal SK. | 10/16/2021 |
| The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence(s). | The anti-oxidant enzyme, Prdx6 might have cis-acting regulatory sequence(s).
Shahnaj S, Potshangbam AM, Chowhan RK, Parray ZA, Kakchingtabam P, Kumari A, Islam A, Khan A, Singh LR, Rahaman H. | 12/5/2020 |
| regulation of the NF-kappaB signaling cascade could be one of the mechanisms of Prx6 action on beta-cells, in particular, through activation of RelA/p65 phosphorylation at Ser536 | Protective Effect of Peroxiredoxin 6 Against Toxic Effects of Glucose and Cytokines in Pancreatic RIN-m5F β-Cells.
Novoselova EG, Glushkova OV, Parfenuyk SB, Khrenov MO, Lunin SM, Novoselova TV, Sharapov MG, Shaev IA, Novoselov VI. | 07/20/2019 |
| Prdx6 upregulation by Cur treatment attenuates ischemic oxidative damage through SP1 induction in rats after stroke. This represents a novel mechanism of Cur-induced neuroprotection against cerebral ischemia. | Prdx6 Upregulation by Curcumin Attenuates Ischemic Oxidative Damage via SP1 in Rats after Stroke.
Jia G, Tan B, Ma J, Zhang L, Jin X, Li C., Free PMC Article | 03/10/2018 |
| Prdx1 and Prdx6 proteins is involved in pulmonary fibrosis induced by silica. | Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue.
Liu N, Xue L, Guan Y, Li QZ, Cao FY, Pang SL, Guan WJ. | 07/1/2017 |
| Data suggest the peroxiredoxin 6 (PRDX6) in microglia protects neuron against oxygen-glucose deprivation and reoxygenation (OGD/R)-induced injury. | [Knockdown of PRDX6 in microglia reduces neuron viability after OGD/R injury].
Tan L, Zhao Y, Jiang B, Yang B, Zhang H. | 01/14/2017 |
| PRDX6 may serve as a biomarker for traumatic brain injury and that autoimmune profiling is a viable strategy for the discovery of novel biomarkers | Autoimmune Profiling Reveals Peroxiredoxin 6 as a Candidate Traumatic Brain Injury Biomarker.
Buonora JE, Mousseau M, Jacobowitz DM, Lazarus RC, Yarnell AM, Olsen CH, Pollard HB, Diaz-Arrastia R, Latour L, Mueller GP., Free PMC Article | 08/27/2016 |
| Our present findings illustrate the molecular changes during radiation-induced skin injury and the important role of PRDX-6 in ameliorating this damage in rats | Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against ionizing radiation.
Zhang S, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J, Zhou J, Wu J, Ding WQ. | 11/22/2014 |
| PRDX6 is an important enzyme for the protection against oxidative stress. | Modulation of the peroxiredoxin system by cytokines in insulin-producing RINm5F cells: down-regulation of PRDX6 increases susceptibility of beta cells to oxidative stress.
Paula FM, Ferreira SM, Boschero AC, Souza KL. | 01/4/2014 |
| a change in the conformation of Prdx6 upon its phosphorylation is the basis for enhancement of PLA(2) enzymatic activity | Increased phospholipase A2 activity with phosphorylation of peroxiredoxin 6 requires a conformational change in the protein.
Rahaman H, Zhou S, Dodia C, Feinstein SI, Huang S, Speicher D, Fisher AB., Free PMC Article | 12/8/2012 |
| Prdx 6 expression in rat brain continually increased in the perinatal period. Dexamethasone injection increased the expression of Prdx 6. | Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
Shim SY, Kim HS, Kim EK, Choi JH. | 06/30/2012 |
| An extrinsic supply of recombinant TAT-PRDX5 and -6 proteins is responsible for inhibiting hyperglycemia-induced retinal pericyte apoptosis. | TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes.
Kubo E, Singh DP, Fatma N, Akagi Y. | 01/21/2010 |
| The MAPKs can mediate phosphorylation of Prdx6 at Thr-177 with a consequent marked increase in its aiPLA(2) activity. | Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A(2) activity.
Wu Y, Feinstein SI, Manevich Y, Chowdhury I, Pak JH, Kazi A, Dodia C, Speicher DW, Fisher AB., Free PMC Article | 01/21/2010 |
| PRDX6 protected retinal ganglion cells from glutamate and TNF-alpha induced cytotoxicity by reducing reactive oxygen species level and NF-kappaB activation, and limiting increased intracellular Ca2+ influx. | Peroxiredoxin 6 delivery attenuates TNF-alpha-and glutamate-induced retinal ganglion cell death by limiting ROS levels and maintaining Ca2+ homeostasis.
Fatma N, Kubo E, Sen M, Agarwal N, Thoreson WB, Camras CB, Singh DP., Free PMC Article | 01/21/2010 |
| Show PRDX6 down-regulation is associated with cataractogenesis and that genetic transduction of PRDX6 can delay cataracts. | TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity.
Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP, Singh DP. | 01/21/2010 |
| analysis of the peroxiredoxin 6 catalytic triad and its role in phospholipid substrate binding | Structure and phospholipase function of peroxiredoxin 6: identification of the catalytic triad and its role in phospholipid substrate binding.
Manevich Y, Reddy KS, Shuvaeva T, Feinstein SI, Fisher AB. | 01/21/2010 |
| Prx I and VI play a crucial role against oxidative stress in vascular smooth muscles during hypertension | Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle.
Lee CK, Kim HJ, Lee YR, So HH, Park HJ, Won KJ, Park T, Lee KY, Lee HM, Kim B. | 01/21/2010 |
| SP-A and Prdx6 directly interact, which provides a mechanism for regulation of the PLA(2) activity of Prdx6 by SP-A | Interaction of surfactant protein A with peroxiredoxin 6 regulates phospholipase A2 activity.
Wu YZ, Manevich Y, Baldwin JL, Dodia C, Yu K, Feinstein SI, Fisher AB. | 01/21/2010 |
| The native 1-Cys Prx existed in the monomeric and dimeric forms. | [Study of the quaternary structure of rat 1-Cys peroxiredoxin].
Bystrova MF, Budanova EN, Novoselov VI, Fesenko EE. | 01/21/2010 |