| Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action. | Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action.
Roth L, Johann K, Hönes GS, Oelkrug R, Wagner L, Hoffmann A, Krohn K, Moeller LC, Weiner J, Heiker JT, Klöting N, Tönjes A, Stumvoll M, Blüher M, Mittag J, Krause K. | 10/5/2023 |
| ZFP423 controls EBF2 coactivator recruitment and PPARgamma occupancy to determine the thermogenic plasticity of adipocytes. | ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytes.
Shao M, Zhang Q, Truong A, Shan B, Vishvanath L, Li L, Seale P, Gupta RK., Free PMC Article | 04/9/2022 |
| ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus. | ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus.
Casoni F, Croci L, Vincenti F, Podini P, Riba M, Massimino L, Cremona O, Consalez GG., Free PMC Article | 01/23/2021 |
| Tight regulation of Zfp423 expression is essential for normal progression of muscle progenitors from proliferation to differentiation. | Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation.
Addison WN, Hall KC, Kokabu S, Matsubara T, Fu MM, Gori F, Baron R., Free PMC Article | 11/9/2019 |
| In vivo, vitamin A supplementation prevents obesity, downregulates Gadd45a expression, and reduces GADD45A binding and DNA demethylation in the Zfp423 promoter. | Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylation.
Wang B, Fu X, Zhu MJ, Du M., Free PMC Article | 06/2/2018 |
| ZFP423 to be expressed in the developing cortex and promote RA-dependent neuronal differentiation. | TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis.
Massimino L, Flores-Garcia L, Di Stefano B, Colasante G, Icoresi-Mazzeo C, Zaghi M, Hamilton BA, Sessa A., Free PMC Article | 03/31/2018 |
| Zfp423/ZNF423 has a role in regulating cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors | Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors.
Casoni F, Croci L, Bosone C, D'Ambrosio R, Badaloni A, Gaudesi D, Barili V, Sarna JR, Tessarollo L, Cremona O, Hawkes R, Warming S, Consalez GG., Free PMC Article | 11/11/2017 |
| These data identify Zfp423 as a molecular brake on adipocyte thermogenesis. | Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program.
Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK., Free PMC Article | 06/24/2017 |
| loss of Zfp423 alters expression of several genes encoding key cilium components, including increased expression of Tulp3. Tulp3 is a direct binding target of Zfp423 and reducing the overexpression of Tulp3 in Zfp423-deficient cells suppresses Smoothened translocation defects. | Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
Hong CJ, Hamilton BA., Free PMC Article | 05/13/2017 |
| Data show that the expression of miR-195a is regulated during adipocyte differentiation and identified Zfp423 as its novel target. | miR-195a inhibits adipocyte differentiation by targeting the preadipogenic determinator Zfp423.
Yun UJ, Song NJ, Yang DK, Kwon SM, Kim K, Kim S, Jo DG, Park WJ, Park KW, Kang H. | 06/28/2016 |
| the antiadipogenic function of Zfp521 is mostly exerted through repression of Zfp423 and the downstream target PPAR-gamma gene. | Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch.
Addison WN, Fu MM, Yang HX, Lin Z, Nagano K, Gori F, Baron R., Free PMC Article | 10/14/2014 |
| Zfp423 binds autoregulatory sites in a developmental cell culture model. | Zfp423 binds autoregulatory sites in p19 cell culture model.
Cho YW, Hong CJ, Hou A, Gent PM, Zhang K, Won KJ, Hamilton BA., Free PMC Article | 01/18/2014 |
| Maternal obesity enhanced Zfp423 expression and adipogenic differentiation during fetal development, at least partially through reducing DNA methylation in the Zfp423 promoter. | Maternal obesity induces epigenetic modifications to facilitate Zfp423 expression and enhance adipogenic differentiation in fetal mice.
Yang QY, Liang JF, Rogers CJ, Zhao JX, Zhu MJ, Du M., Free PMC Article | 12/28/2013 |
| Constitutive expression of a C-terminal mutant OAZ that selectively disrupts OAZ-O/E interaction while retaining other activities, exhibits apparently normal OSN differentiation. | Zfp423/OAZ mutation reveals the importance of Olf/EBF transcription activity in olfactory neuronal maturation.
Roby YA, Bushey MA, Cheng LE, Kulaga HM, Lee SJ, Reed RR., Free PMC Article | 01/26/2013 |
| Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. | Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells.
Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM., Free PMC Article | 06/16/2012 |
| Zfp423(-/-) hemisphere malformations are shaped by both genetic and non-genetic factors to produce distinct phenotypes. | Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice.
Alcaraz WA, Chen E, Valdes P, Kim E, Lo YH, Vo J, Hamilton BA., Free PMC Article | 01/21/2012 |
| ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. | ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression.
Masserdotti G, Badaloni A, Green YS, Croci L, Barili V, Bergamini G, Vetter ML, Consalez GG., Free PMC Article | 10/30/2010 |
| Zfp423 as a transcriptional regulator of preadipocyte determination | Transcriptional control of preadipocyte determination by Zfp423.
Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM., Free PMC Article | 04/12/2010 |
| Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. | Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia.
Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura T, Honda H. | 01/21/2010 |
| these experiments suggest that OAZ participates in a developmental switch regulating the transition from differentiation to maturation in ORNs. | Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis.
Cheng LE, Reed RR., Free PMC Article | 01/21/2010 |
| Homozygous Zfp423 null mice are runted and ataxic, the cerebellum is underdeveloped, and the vermis is severely reduced. In the remaining cerebellar structures, the Purkinje cells are poorly developed and mislocalized. | Zfp423 is required for normal cerebellar development.
Warming S, Rachel RA, Jenkins NA, Copeland NG., Free PMC Article | 01/21/2010 |
| Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. | Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA, Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA., Free PMC Articles: PMC1748242, PMC1748242 | 01/21/2010 |
| Ebfaz can substitute for the upregulated expression of Evi3 in B-cell disease and has a role in hematopoietic cancer | Early B-cell factor-associated zinc-finger gene is a frequent target of retroviral integration in murine B-cell lymphomas.
Warming S, Suzuki T, Yamaguchi TP, Jenkins NA, Copeland NG. | 01/21/2010 |
| Neural precursor proliferation is reduced in Zfp423 null cerebellum, especially near the midline. Radial glia are morphologically abnormal. Cell layers appear nearly normal to grossly disorganized. | Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA, Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA., Free PMC Articles: PMC1748242, PMC1748242 | 02/15/2007 |