| Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes. | Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.
Evrard M, Wynne-Jones E, Peng C, Kato Y, Christo SN, Fonseca R, Park SL, Burn TN, Osman M, Devi S, Chun J, Mueller SN, Kannourakis G, Berzins SP, Pellicci DG, Heath WR, Jameson SC, Mackay LK., Free PMC Article | 01/8/2022 |
| Beside representing a promising strategy to take into consideration for the development of alternative therapeutic options for Huntington's disease, selective stimulation of S1P receptor 5 may be also seen as an effective approach to target brain vasculature defects in the disease | Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Di Pardo A, Castaldo S, Amico E, Pepe G, Marracino F, Capocci L, Giovannelli A, Madonna M, van Bergeijk J, Buttari F, van der Kam E, Maglione V. | 03/16/2019 |
| reduced frequency of patrolling monocytes in bone marrow of KO mice | S1PR5 is pivotal for the homeostasis of patrolling monocytes.
Debien E, Mayol K, Biajoux V, Daussy C, De Aguero MG, Taillardet M, Dagany N, Brinza L, Henry T, Dubois B, Kaiserlian D, Marvel J, Balabanian K, Walzer T. | 09/7/2013 |
| Coordinated changes in CXCR4 and S1P5 responsiveness govern NK-cell trafficking. | Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
Mayol K, Biajoux V, Marvel J, Balabanian K, Walzer T. | 01/14/2012 |
| Fndings suggest that S1P(5) may mediate the effects of S1P in terms of regulating ERK-1/2 signaling in ES cells. | Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.
Rodgers A, Mormeneo D, Long JS, Delgado A, Pyne NJ, Pyne S. | 03/1/2010 |
| These findings identify S1P5 as a T-bet-induced gene that is required for natural killer cell egress from lymph nodes and bone marrow. | T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow.
Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J., Free PMC Article | 01/21/2010 |
| The immune modulator FTY720 targets sphingosine 1-phosphate receptors. | The immune modulator FTY720 targets sphingosine 1-phosphate receptors.
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. | 01/21/2010 |
| Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells.
Yopp AC, Ochando JC, Mao M, Ledgerwood L, Ding Y, Bromberg JS. | 01/21/2010 |
| The molecular identity, functional properties, and expression profile of the S1P5 (Edg-8) receptor have been characterized. | Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors.
Im DS, Clemens J, Macdonald TL, Lynch KR. | 01/21/2010 |
| Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell. | Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C., Free PMC Article | 01/21/2010 |
| KLF2 regulates T cell homeostasis at least partly by controlling CD62L and S1P1 expression, and therefore T cell egress from the thymus and circulation in the periphery. | Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription.
Bai A, Hu H, Yeung M, Chen J. | 01/21/2010 |