| The deficiency of Maged1 attenuates Parkinson's disease progression in mice. | The deficiency of Maged1 attenuates Parkinson's disease progression in mice.
Wang J, Xu SY, Ye ZY, Sun ZN, Zhang JQ, Qi C, Liu R, Gao X, He C, You WY, Gao J., Free PMC Article | 02/15/2023 |
| Knockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells. | Knockdown of Maged1 inhibits cell cycle progression and causes cell death in mouse embryonic stem cells.
Park S, Kwon W, Kim HY, Ji YR, Kim D, Kim W, Han JE, Cho GJ, Yun S, Kim MO, Ryoo ZY, Han SH, Park JK, Choi SK. | 06/11/2022 |
| NRAGE is an important regulator of odontogenic differentiation of odontoblasts by inhibiting the NF-kappaB signaling pathway through binding to IKKbeta. | Knockdown of NRAGE induces odontogenic differentiation by activating NF-κB signaling in mouse odontoblast-like cells.
Wu Q, Li J, Song P, Chen J, Xu Y, Qi S, Ma J, Pan Q. | 07/4/2020 |
| negative regulator of PPARgamma activity, adipogenesis, and insulin sensitivity | Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1.
Wang Q, Tang J, Jiang S, Huang Z, Song A, Hou S, Gao X, Ruan HB. | 09/14/2019 |
| This work identifies Maged1 as a critical molecule involved in cellular processes and behaviours related to addiction. | Deletion of Maged1 in mice abolishes locomotor and reinforcing effects of cocaine.
De Backer JF, Monlezun S, Detraux B, Gazan A, Vanopdenbosch L, Cheron J, Cannazza G, Valverde S, Cantacorps L, Nassar M, Venance L, Valverde O, Faure P, Zoli M, De Backer O, Gall D, Schiffmann SN, de Kerchove d'Exaerde A., Free PMC Article | 06/8/2019 |
| Both transient and stable expression of Necdin induced osteoblast-specific markers in an osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and promoter activation. | Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
Ju H, Lee S, Lee J, Ghil S. | 09/23/2017 |
| MAGED1 as a novel regulator of osteoblastogenesis, osteoclastogenesis, and bone remodeling in a mouse model | MAGED1 is a negative regulator of bone remodeling in mice.
Liu M, Xu L, Ma X, Xu J, Wang J, Xian M, Zhou X, Wang M, Wang F, Qin A, Pan Q, Wen C. | 05/7/2016 |
| Maged1 deficiency prevented the interaction of Maged1 with cAMP response element-binding protein (CREB). | Maged1 co-interacting with CREB through a hexapeptide repeat domain regulates learning and memory in mice.
Yang J, Lai B, Xu A, Liu Y, Li X, Zhao Y, Li W, Ji M, Hu G, Gao X, Gao J. | 10/24/2015 |
| NRAGE is a potent regulator of proliferation and odontoblastic differentiation of mouse dental pulp cells, which might be via the NF-kappaB signalling pathway. | Effects of neurotrophin receptor-mediated MAGE homology on proliferation and odontoblastic differentiation of mouse dental pulp cells.
Qi S, Wu Q, Ma J, Li J, Chen F, Xu Y, Pan Q, Wang R., Free PMC Article | 06/20/2015 |
| Show Ror2 expression is higher in highly metastatic cell line than in low metastatic variant cell line. Our data show that Ror2 is a potential factor in the tumorigenesis and metastasis in a Src-dependent manner that is negatively regulated by NRAGE. | Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE.
Lai SS, Xue B, Yang Y, Zhao L, Chu CS, Hao JY, Wen CJ. | 04/6/2013 |
| We conclude that Maged1 is required for OT processing or stability. A decrease in mature OT levels in Maged1 mutants affects social interactions and possibly other behavioral processes | Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.
Dombret C, Nguyen T, Schakman O, Michaud JL, Hardin-Pouzet H, Bertrand MJ, De Backer O. | 04/6/2013 |
| Maged1 is involved in osteoblast proliferation and differentiation. Mice deficient in Maged1 protein had decreased bone mineral density (BMD) | Systems genetic analysis of osteoblast-lineage cells.
Calabrese G, Bennett BJ, Orozco L, Kang HM, Eskin E, Dombret C, De Backer O, Lusis AJ, Farber CR., Free PMC Article | 04/3/2013 |
| the present findings suggest a novel role for MAGE-D1 in depressive behaviors: modulating SERT ubiquitylation. | MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.
Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya T, Miyamoto Y, Yamada K, Noda Y, Nabeshima T., Free PMC Article | 05/19/2012 |
| XIAP-TAB1-TAK1 complex is dependent on NRAGE for IKK-alpha/beta phosphorylation and NF-kappaB activation. | A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells.
Rochira JA, Matluk NN, Adams TL, Karaczyn AA, Oxburgh L, Hess ST, Verdi JM., Free PMC Article | 11/26/2011 |
| MAGED1 binds to nuclear receptor RORalpha to bring about positive and negative effects on core clock genes of Bmal1, Rev-erbalpha and E4bp4 expression through the Rev-Erbalpha/ROR responsive elements (RORE). | Interaction of MAGED1 with nuclear receptors affects circadian clock function.
Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y., Free PMC Article | 06/14/2010 |
| NRAGE induces NF-kappaB activation and MIF expression in P19 cells | A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.
Matluk N, Rochira JA, Karaczyn A, Adams T, Verdi JM., Free PMC Article | 05/10/2010 |
| MHD2 of NRAGE was not necessary for BMP-induced p38MAPK activation or caspase-mediated apoptosis. | Mapping of NRAGE domains reveals clues to cell viability in BMP signaling.
Rochira JA, Cowling RA, Himmelfarb JS, Adams TL, Verdi JM., Free PMC Article | 03/29/2010 |
| NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. | NRAGE: a potential rheostat during branching morphogenesis.
Nikopoulos GN, Martins JF, Adams TL, Karaczyn A, Adams D, Vary C, Oxburgh L, Verdi JM., Free PMC Article | 01/21/2010 |
| NRAGE plays an important role in apoptotic-signaling in vivo. | NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.
Bertrand MJ, Kenchappa RS, Andrieu D, Leclercq-Smekens M, Nguyen HN, Carter BD, Muscatelli F, Barker PA, De Backer O., Free PMC Article | 01/21/2010 |
| Our results suggest that interaction of cytosolic PrP and NRAGE could affect neuronal viability. | Interaction of PrP with NRAGE, a protein involved in neuronal apoptosis.
Bragason BT, Palsdottir A. | 01/21/2010 |
| necdin and MAGE-D1 cooperate to modulate the function of Dlx/Msx homeodomain proteins in cellular differentiation | Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells.
Kuwajima T, Taniura H, Nishimura I, Yoshikawa K. | 01/21/2010 |
| The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3 | Comparative expression analysis of the MAGED genes during embryogenesis and brain development.
Bertrand M, Huijbers I, Chomez P, De Backer O. | 01/21/2010 |
| roles for NRAGE as a mediator of precursor apoptosis and a repressor of cell cycle progression in neural development | Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.
Kendall SE, Goldhawk DE, Kubu C, Barker PA, Verdi JM. | 01/21/2010 |
| NRAGE as an integral component in bone morphogenetic proteins signaling and clarify its role during neural progenitor development | NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade.
Kendall SE, Battelli C, Irwin S, Mitchell JG, Glackin CA, Verdi JM., Free PMC Article | 01/21/2010 |
| receptor tyrosine kinase-like orphan receptor 2(Ror2) sequesters Dlxin-1 in membranous compartments, thereby affecting the transcriptional function of Mhomeobox, msh-like 2(msx2) | The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution.
Matsuda T, Suzuki H, Oishi I, Kani S, Kuroda Y, Komori T, Sasaki A, Watanabe K, Minami Y. | 01/21/2010 |