| Amplification of autoimmune organ damage by NKp46-activated ILC1s. | Amplification of autoimmune organ damage by NKp46-activated ILC1s.
Biniaris-Georgallis SI, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, Karmalkar T, Kasapi A, Lenac Rovis T, Jelencic V, Bejarano DA, Fabry L, Papacharalampous M, Mattiola I, Molgora M, Hou J, Hublitz KW, Heinrich F, Guerra GM, Durek P, Patone G, Lindberg EL, Maatz H, Hölsken O, Krönke G, Mortha A, Voll RE, Clarke AJ, Hauser AE, Colonna M, Thurley K, Schlitzer A, Schneider C, Stamatiades EG, Mashreghi MF, Jonjic S, Hübner N, Diefenbach A, Kanda M, Triantafyllopoulou A. | 11/8/2024 |
| The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. | The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
Sen Santara S, Lee DJ, Crespo Â, Hu JJ, Walker C, Ma X, Zhang Y, Chowdhury S, Meza-Sosa KF, Lewandrowski M, Zhang H, Rowe M, McClelland A, Wu H, Junqueira C, Lieberman J., Free PMC Article | 04/20/2023 |
| NK cells that differ in expression of NKp46 might play different roles in endometrium. | NK cells that differ in expression of NKp46 might play different roles in endometrium.
Mai C, Fukui A, Takeyama R, Yamamoto M, Saeki S, Yamaya A, Kato T, Ukita Y, Wakimoto Y, Shibahara H. | 02/5/2022 |
| Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss. | Co-expression of NKp46 with activating or inhibitory receptors on, and cytokine production by, uterine endometrial NK cells in recurrent pregnancy loss.
Takeyama R, Fukui A, Mai C, Yamamoto M, Saeki S, Yamaya A, Shibahara H. | 12/11/2021 |
| Expression of natural cytotoxicity receptor NKp46 on peripheral blood natural killer cells in women with a history of recurrent implantation failures. | Expression of natural cytotoxicity receptor NKp46 on peripheral blood natural killer cells in women with a history of recurrent implantation failures.
Dons'koi BV, Osypchuk DV, Chernyshov VP, Khazhylenko KG. | 08/21/2021 |
| Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46. | Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46.
McQuaid SL, Loughran ST, Power PA, Maguire P, Szczygiel A, Johnson PA., Free PMC Article | 10/24/2020 |
| The Natural Cytotoxicity Receptors in Health and Disease. | The Natural Cytotoxicity Receptors in Health and Disease.
Barrow AD, Martin CJ, Colonna M., Free PMC Article | 10/3/2020 |
| STAT3 directly bound to the promoter of NKp46, an important activating receptor of NK cells, to regulate its transcription and expression. | STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients.
Zheng B, Yang Y, Han Q, Yin C, Pan Z, Zhang J. | 05/30/2020 |
| Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. | Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Gauthier L, Morel A, Anceriz N, Rossi B, Blanchard-Alvarez A, Grondin G, Trichard S, Cesari C, Sapet M, Bosco F, Rispaud-Blanc H, Guillot F, Cornen S, Roussel A, Amigues B, Habif G, Caraguel F, Arrufat S, Remark R, Romagné F, Morel Y, Narni-Mancinelli E, Vivier E. | 03/14/2020 |
| NKp46 is selectively expressed in aggressive subtypes of primary Gastrointestinal T-cell lymphoma. | NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: a CELAC study.
Cheminant M, Bruneau J, Malamut G, Sibon D, Guegan N, van Gils T, Cording S, Trinquand A, Verkarre V, Lhermitte L, Brousse N, Jannot AS, Khater S, Frenzel L, Delarue R, Suarez F, Marçais A, Mulder CJ, Macintyre E, Asnafi V, Pouyet L, Bonnafous C, Lhospice F, Molina TJ, Meresse B, Cellier C, Cerf-Bensussan N, Hermine O, CELAC network°. | 08/24/2019 |
| The regulation of T cell proliferation during HPIV3 infection is mediated via NK receptors NKp44 and NKp46 and involves the surface glycoprotein haemagglutinin-neuraminidase but not the fusion protein of the virus. | Haemagglutinin-neuraminidase from HPIV3 mediates human NK regulation of T cell proliferation via NKp44 and NKp46.
McQuaid S, Loughran S, Power P, Maguire P, Walls D, Cusi MG, Orvell C, Johnson P. | 03/30/2019 |
| this paper shows that the decreased expression of activating receptor NKp46 on peripheral blood NK cells is positively associated with gastric cancer progression | Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer.
Han B, Mao FY, Zhao YL, Lv YP, Teng YS, Duan M, Chen W, Cheng P, Wang TT, Liang ZY, Zhang JY, Liu YG, Guo G, Zou QM, Zhuang Y, Peng LS., Free PMC Article | 12/22/2018 |
| HIF-1alpha inhibits NCR1/NKp46 pathway through up-regulating miR-224, which affects the killing capability of NK cells on prostate cancer, thus inducing immune escape of tumor cells. | HIF-1α induces immune escape of prostate cancer by regulating NCR1/NKp46 signaling through miR-224.
Chen CH, Li SX, Xiang LX, Mu HQ, Wang SB, Yu KY. | 12/1/2018 |
| The authors demonstrated that mutant NKp46 W32R is aberrantly glycosylated, accumulates in the endoplasmic reticulum, and is unstable on the cell surface. | Expression and function of NKp46 W32R: the human homologous protein of mouse NKp46 W32R (Noé).
Glasner A, Isaacson B, Mandelboim O., Free PMC Article | 10/20/2018 |
| Low NKp46 expression on on NK cells is associated with Nasopharyngeal Carcinoma. | Analysis of the Expression of Surface Receptors on NK Cells and NKG2D on Immunocytes in Peripheral Blood of Patients with Nasopharyngeal Carcinoma.
Xu Y, Zhou R, Huang C, Zhang M, Li J, Zong J, Qiu S, Lin S, Chen H, Ye Y, Pan J., Free PMC Article | 09/22/2018 |
| Signaling via the natural killer cell receptor NKp46 (human) and Ncr1 (mouse) induced interferon-gamma (IFN-gamma) secretion from intratumoral natural killer cells. | NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis.
Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, Sexl V, Jonjic S, Seliger B, Zitvogel L, Mandelboim O. | 09/1/2018 |
| findings show HIV reservoir size is dependent on the presence of a defined NK cell population with a specific transcriptional signature: high NCR (NKp46 and NKp30) and IFN-gamma inducibility upon NCR and cytokine receptor engagement | Control of the HIV-1 DNA Reservoir Is Associated In Vivo and In Vitro with NKp46/NKp30 (CD335 CD337) Inducibility and Interferon Gamma Production by Transcriptionally Unique NK Cells.
Marras F, Casabianca A, Bozzano F, Ascierto ML, Orlandi C, Di Biagio A, Pontali E, Dentone C, Orofino G, Nicolini L, Taramasso L, Magnani M, Marincola FM, Wang E, Moretta L, De Maria A., Free PMC Article | 12/9/2017 |
| NKp46 cleavage by Cathepsin G severely impairs NKp46-mediated responses of Natural killer cells. | Neutrophils can disarm NK cell response through cleavage of NKp46.
Valayer A, Brea D, Lajoie L, Avezard L, Combes-Soia L, Labas V, Korkmaz B, Thibault G, Baranek T, Si-Tahar M. | 09/2/2017 |
| The NKp46 and NKp46-ligand interaction contributes to NK cell activation. | Frequency and role of NKp46 and NKG2A in hepatitis B virus infection.
Yoshioka T, Tatsumi T, Miyagi T, Mukai K, Nishio K, Nishio A, Yokoyama Y, Suda T, Kegasawa T, Shigekawa M, Hikita H, Sakamori R, Takehara T., Free PMC Article | 08/26/2017 |
| this study shows that the NKp46-activating receptor recognizes an unknown ligand expressed by human metapneumovirus-infected cells | NK-cell receptors NKp46 and NCR1 control human metapneumovirus infection.
Diab M, Glasner A, Isaacson B, Bar-On Y, Drori Y, Yamin R, Duev-Cohen A, Danziger O, Zamostiano R, Mandelboim M, Jonjic S, Bacharach E, Mandelboim O. | 07/15/2017 |
| Intrahepatic NKp46 NK cells exhibited anti-HCV activity via cell-to-cell contact. The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals. | Functional Behavior of NKp46-Positive Intrahepatic Natural Killer Cells Against Hepatitis C Virus Reinfection After Liver Transplantation.
Tanimine N, Tanaka Y, Abe T, Piao J, Chayama K, Ohdan H. | 07/2/2016 |
| Taken together, these results demonstrate that endogenous levels of IFN-alpha secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4+ primary T cells via the engagement of NKp46 and NKG2D. | Lysis of HIV-1-infected autologous CD4+ primary T cells by interferon-alpha-activated NK cells requires NKp46 and NKG2D.
Tomescu C, Mavilio D, Montaner LJ., Free PMC Article | 06/28/2016 |
| NKp46 was thus involved in the production of serine proteases and interleukin-22 in human mast cells. | NKp46 regulates the production of serine proteases and IL-22 in human mast cells in urticaria pigmentosa.
Ueshima C, Kataoka TR, Hirata M, Koyanagi I, Honda T, Tsuruyama T, Okayama Y, Seiyama A, Haga H. | 06/11/2016 |
| Age and CMV serostatus influence the expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated natural killer cells. | Expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated NK cells from healthy donors according to CMV-serostatus and age.
Campos C, López N, Pera A, Gordillo JJ, Hassouneh F, Tarazona R, Solana R. | 06/4/2016 |
| Ncr1-Noe proteins accumulate in the endoplasmic reticulum, and that the expression of Ncr1-Noe proteins, but not WT Ncr1, leads to increased Helios expression | Expression, Function, and Molecular Properties of the Killer Receptor Ncr1-Noé.
Glasner A, Simic H, Miklić K, Roth Z, Berhani O, Khalaila I, Jonjic S, Mandelboim O. | 01/2/2016 |