| RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli. | RfaH Counter-Silences Inhibition of Transcript Elongation by H-NS-StpA Nucleoprotein Filaments in Pathogenic Escherichia coli.
Hustmyer CM, Wolfe MB, Welch RA, Landick R., Free PMC Article | 03/2/2023 |
| Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators. | Hierarchy of transcription factor network in Escherichia coli K-12: H-NS-mediated silencing and Anti-silencing by global regulators.
Ishihama A, Shimada T. | 02/5/2022 |
| H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division. | H-NS, IHF, and DnaA lead to changes in nucleoid organizations, replication initiation, and cell division.
Huang T, Yuan H, Fan L, Moregen M. | 09/19/2020 |
| It has been found that H-NS showed growth phase-dependent relocalization in response to hyperosmotic shock. | Growth Phase-Dependent Chromosome Condensation and Heat-Stable Nucleoid-Structuring Protein Redistribution in Escherichia coli under Osmotic Stress.
Rafiei N, Cordova M, Navarre WW, Milstein JN., Free PMC Article | 06/13/2020 |
| The results show that high-expression clones carry insertions that are not correlated with HNS binding. Conversely, binding of H-NS correlates with transgene silencing. | Early fate of exogenous promoters in E. coli.
Yousuf M, Iuliani I, Veetil RT, Seshasayee ASN, Sclavi B, Cosentino Lagomarsino M., Free PMC Article | 05/23/2020 |
| H-NS specifically represses LEE5 promoter activity and Ler alleviates the repression by H-NS. | The mechanism underlying Ler-mediated alleviation of gene repression by H-NS.
Shin M. | 06/24/2017 |
| Transcription and stability of cas3 in Deltahns cells is limiting for resistance to phage. | Cas3 is a limiting factor for CRISPR-Cas immunity in Escherichia coli cells lacking H-NS.
Majsec K, Bolt EL, Ivančić-Baće I., Free PMC Article | 10/22/2016 |
| we propose that, during E. coli evolution, the conservation of H-NS binding sites resulted in the diversification of the regulation of horizontally transferred genes, which may have facilitated E. coli adaptation to new ecological niches | H-NS Facilitates Sequence Diversification of Horizontally Transferred DNAs during Their Integration in Host Chromosomes.
Higashi K, Tobe T, Kanai A, Uyar E, Ishikawa S, Suzuki Y, Ogasawara N, Kurokawa K, Oshima T., Free PMC Article | 05/14/2016 |
| Through DNA binding, the two proteins interplay to form a transient ternary complex Fpg/DNA/HU which results in the release of Fpg and the molecular entrapment of SSBs by HU | The nucleoid-associated protein HU enhances 8-oxoguanine base excision by the formamidopyrimidine-DNA glycosylase.
Le Meur R, Culard F, Nadan V, Goffinont S, Coste F, Guerin M, Loth K, Landon C, Castaing B. | 12/19/2015 |
| The fdeC gene encodes a protein that is expressed at the cell surface and promotes biofilm formation under continuous-flow conditions and is repressed by the global regulator H-NS. | The Intimin-Like Protein FdeC Is Regulated by H-NS and Temperature in Enterohemorrhagic Escherichia coli.
Easton DM, Allsopp LP, Phan MD, Moriel DG, Goh GK, Beatson SA, Mahony TJ, Cobbold RN, Schembri MA., Free PMC Article | 12/19/2015 |
| It was concluded that H-NS exerts maximum repression of LEE5 via the specific sequence at around -138 and subsequently contacts a subunit of RNAP through oligomerization. | Identification of high-specificity H-NS binding site in LEE5 promoter of enteropathogenic Esherichia coli (EPEC).
Bhat AP, Shin M, Choy HE. | 02/14/2015 |
| Also, DeltahnsDeltastpA double mutants simultaneously lacking H-NS and its paralog StpA showed more severe reductions in ompW expression at 37 degrees C, resulting in the complete loss of OmpW. | Expression of the Escherichia coli ompW colicin S4 receptor gene is regulated by temperature and modulated by the H-NS and StpA nucleoid-associated proteins.
Brambilla L, Morán-Barrio J, Viale AM. | 11/22/2014 |
| Bicyclomycin treatment leads to a decrease in binding signal for H-NS to the E. coli chromosome. | Inhibition of factor-dependent transcription termination in Escherichia coli might relieve xenogene silencing by abrogating H-NS-DNA interactions in vivo.
Chandraprakash D, Seshasayee AS. | 10/4/2014 |
| Both the DNA binding sites of H-NS as well as the function of StpA as a backup system might be selected for silencing highly transcribable genes. | Genomic analysis reveals epistatic silencing of "expensive" genes in Escherichia coli K-12.
Srinivasan R, Chandraprakash D, Krishnamurthi R, Singh P, Scolari VF, Krishna S, Seshasayee AS. | 01/25/2014 |
| We show that H-NS modulates the expression of the nrdAB and nrdDG operons in aerobically and in anaerobically growing cells. | H-NS is a novel transcriptional modulator of the ribonucleotide reductase genes in Escherichia coli.
Cendra Mdel M, Juárez A, Madrid C, Torrents E., Free PMC Article | 11/16/2013 |
| SspA positively regulates the expression of enterohemorrhagic Escherichia coli virulence factors by restricting the intracellular level of H-NS. | SspA up-regulates gene expression of the LEE pathogenicity island by decreasing H-NS levels in enterohemorrhagic Escherichia coli.
Hansen AM, Jin DJ., Free PMC Article | 06/15/2013 |
| H-NS represses LEE5p by binding to a cluster of A tracks upstream of -114 of the promoter. | Gene silencing by H-NS from distal DNA site.
Shin M, Lagda AC, Lee JW, Bhat A, Rhee JH, Kim JS, Takeyasu K, Choy HE. | 04/6/2013 |
| EcpR-mediated activation is aided by integration host factor (IHF), which is essential for counteracting the repression exerted by histone-like nucleoid-structuring protein (H-NS) on the ecp promoter. | Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS in attaching and effacing Escherichia coli.
Martínez-Santos VI, Medrano-López A, Saldaña Z, Girón JA, Puente JL., Free PMC Article | 11/24/2012 |
| RcsB-BglJ activates one of two H-NS-StpA repressed leuO promoters. | RcsB-BglJ activates the Escherichia coli leuO gene, encoding an H-NS antagonist and pleiotropic regulator of virulence determinants.
Stratmann T, Pul Ü, Wurm R, Wagner R, Schnetz K. | 08/11/2012 |
| The product of bacreriophage T7 gene 5.5 (gp5.5) forms a stable complex with the Escherichia coli histone-like protein H-NS and transfer RNAs (tRNAs). | Gene 5.5 protein of bacteriophage T7 in complex with Escherichia coli nucleoid protein H-NS and transfer RNA masks transfer RNA priming in T7 DNA replication.
Zhu B, Lee SJ, Tan M, Wang ED, Richardson CC., Free PMC Article | 08/4/2012 |
| the attractive force that governs the Cnu-H-NS interaction is an ionic bond, unlike the hydrophobic interaction that is the major attractive force in most proteins. | A mutational study of Cnu reveals attractive forces between Cnu and H-NS.
Yun SH, Ji SC, Jeon HJ, Wang X, Lee Y, Choi BS, Lim HM., Free PMC Article | 07/21/2012 |
| HNS control the integrase IntI1 and integron promoters expression. | Regulation of the integrase and cassette promoters of the class 1 integron by nucleoid-associated proteins.
Cagle CA, Shearer JES, Summers AO. | 01/28/2012 |
| LeuO is a major player in antagonistic interplay against the universal silencer H-NS. | Novel roles of LeuO in transcription regulation of E. coli genome: antagonistic interplay with the universal silencer H-NS.
Shimada T, Bridier A, Briandet R, Ishihama A. | 01/28/2012 |
| It binds to a middle domain of FliG that bridges the core parts of the rotor and parts nearer the edge that interact with the stator. | Adjusting the spokes of the flagellar motor with the DNA-binding protein H-NS.
Paul K, Carlquist WC, Blair DF., Free PMC Article | 12/10/2011 |
| The 5.5 proteins utilize a previously undescribed mechanism of H-NS antagonism that further highlights the critical importance that higher-order oligomerization plays in H-NS-mediated gene repression. | The 5.5 protein of phage T7 inhibits H-NS through interactions with the central oligomerization domain.
Ali SS, Beckett E, Bae SJ, Navarre WW., Free PMC Article | 10/29/2011 |