| Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-alpha-Pix to Rac1 to activate the MAPK pathway. | Fermitin family member 2 promotes melanoma progression by enhancing the binding of p-α-Pix to Rac1 to activate the MAPK pathway.
Huang S, Deng W, Wang P, Yan Y, Xie C, Cao X, Chen M, Zhang C, Shi D, Dong Y, Cheng P, Xu H, Zhu W, Hu Z, Tang B, Zhu J., Free PMC Article | 08/28/2024 |
| The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma. | The pathological significance and potential mechanism of ARHGEF6 in lung adenocarcinoma.
Zheng T, Zhou H, Zheng Z, Guo Y, Liu J, Zhang J, Li S. | 04/21/2023 |
| Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study. | Clinical implication and potential function of ARHGEF6 in acute myeloid leukemia: An in vitro study.
Li K, Wang H, Yang C, Li C, Xue B, Zhou J., Free PMC Article | 04/12/2023 |
| Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs. | Genetic Variants in ARHGEF6 Cause Congenital Anomalies of the Kidneys and Urinary Tract in Humans, Mice, and Frogs.
Klämbt V, Buerger F, Wang C, Naert T, Richter K, Nauth T, Weiss AC, Sieckmann T, Lai E, Connaughton DM, Seltzsam S, Mann N, Majmundar AJ, Wu CW, Onuchic-Whitford AC, Shril S, Schneider S, Schierbaum L, Dai R, Bekheirnia MR, Joosten M, Shlomovitz O, Vivante A, Banne E, Mane S, Lifton RP, Kirschner KM, Kispert A, Rosenberger G, Fischer KD, Lienkamp SS, Zegers MMP, Hildebrandt F., Free PMC Article | 02/11/2023 |
| Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma. | Comprehensive analysis identifies ARHGEF6 as a potential prognostic and immunological biomarker in lung adenocarcinoma.
Wang N, Li Y, Zhou X, Wang X, Yang G. | 02/4/2023 |
| In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15]. | X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans.
Lee HS, Oh H, Yang SK, Baek J, Jung S, Hong M, Kim KM, Shin HD, Kim KJ, Park SH, Ye BD, Han B, Song K. | 06/2/2018 |
| we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease | Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
Zhou W, Li X, Premont RT., Free PMC Article | 08/5/2017 |
| show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex | Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.
Nagy Z, Wynne K, von Kriegsheim A, Gambaryan S, Smolenski A., Free PMC Article | 05/14/2016 |
| The novel recycling regulator alpha-PIX and the degradation factor c-Cbl closely cooperate in the regulation of EGFR trafficking. | αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor.
Kortüm F, Harms FL, Hennighausen N, Rosenberger G., Free PMC Article | 04/30/2016 |
| c-Cbl negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl in C6 and A172 glioma cells is responsible for their malignant behavior | c-Cbl regulates αPix-mediated cell migration and invasion.
Seong MW, Park JH, Yoo HM, Yang SW, Oh KH, Ka SH, Park DE, Lee ST, Chung CH. | 02/14/2015 |
| results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells. | Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells.
Maiti AK. | 06/28/2010 |
| These findings suggest that alpha Pix plays an important role in mutant huntingtin aggregation. | alpha Pix enhances mutant huntingtin aggregation.
Eriguchi M, Mizuta H, Luo S, Kuroda Y, Hara H, Rubinsztein DC. | 05/31/2010 |
| The interaction of alphaPix with CagA activates PAK1, ERK and NF-kappaB, which induces IL-8 expression in H. pylori-infected gastric epithelial cells. | alphaPix interacts with Helicobacter pylori CagA to induce IL-8 expression in gastric epithelial cells.
Lim JW, Kim KH, Kim H. | 03/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K. | 01/20/2010 |
| Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation. | The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.
Flanders JA, Feng Q, Bagrodia S, Laux MT, Singavarapu A, Cerione RA. | 01/21/2010 |
| Data suggest that Rac-dependent activation of the NFkappaB pathway may be a critical element promoting thrombin-induced tissue factor expression and activity, and thus a prothrombotic state in pulmonary hypertension. | Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway.
Djordjevic T, Hess J, Herkert O, Görlach A, BelAiba RS. | 01/21/2010 |
| PAK4 and alphaPIX can induce highly localized changes in actin dynamics and thereby regulate size and number of podosomes in primary human macrophages. | PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.
Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S. | 01/21/2010 |
| The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding | The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.
Vikis HG, Li W, Guan KL., Free PMC Article | 01/21/2010 |
| Whereas alphaPIX guanine nucleotide exchange factor activity contributes to enhanced formation of cellular protrusions, the GEF-independent association with calpain 4 leads to induction of a yet unknown signaling cascade resulting in cell spreading. | AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading.
Rosenberger G, Gal A, Kutsche K. | 01/21/2010 |
| Semi-quantitative RT-PCR experiments with 6 of those genes confirmed higher expression of DNCH2, ARHGEF6, NPM1 and SRI and lower expression of NRGN and TM4SF2 in GBM tumors. | Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.
Yokota T, Kouno J, Adachi K, Takahashi H, Teramoto A, Matsumoto K, Sugisaki Y, Onda M, Tsunoda T. | 01/21/2010 |
| phosphorylation of CagA induces the dephosphorylation of alpha-Pix, which may modulate cytoskeletal changes of gastric epithelial cells through PAK | Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells.
Baek HY, Lim JW, Kim H. | 01/21/2010 |