| Elevated Levels of the Escherichia coli nrdAB-Encoded Ribonucleotide Reductase Counteract the Toxicity Caused by an Increased Abundance of the beta Clamp. | Elevated Levels of the Escherichia coli nrdAB-Encoded Ribonucleotide Reductase Counteract the Toxicity Caused by an Increased Abundance of the β Clamp.
Babu VMP, Homiski C, Scotland MK, Chodavarapu S, Kaguni JM, Sutton MD., Free PMC Article | 12/25/2021 |
| Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay. | Subunit Interaction Dynamics of Class Ia Ribonucleotide Reductases: In Search of a Robust Assay.
Ravichandran K, Olshansky L, Nocera DG, Stubbe J., Free PMC Article | 11/21/2020 |
| Elimination of 6 helicases lowered NrdA production further, whereas overexpression of any RNA helicase partially reversed the downregulation. UV stress completely reversed down-regulation of NrdA production | REP sequences: Mediators of the environmental stress response?
Liang W, Deutscher MP., Free PMC Article | 11/19/2016 |
| The present results identifying a large, new set of E. coli mutator strains with mutations of nrdAB ribonucleotide reductase(RNR)confirm the important control that RNR exerts on the cellular mutation rate and provide novel insights into the RNR feedback regulatory mechanisms. | Novel mutator mutants of E. coli nrdAB ribonucleotide reductase: insight into allosteric regulation and control of mutation rates.
Ahluwalia D, Bienstock RJ, Schaaper RM., Free PMC Article | 11/24/2012 |
| RNR101 is unstable at 42 degrees C ; its degradation is prevented by rifampicin; inactivation of DnaA protein by allows chromosome replication in absence of rifampicin and suppresses nucleoid segregation and cell division defects seen in nrdA101 mutant at 42 degrees C | Overlap of replication rounds disturbs the progression of replicating forks in a ribonucleotide reductase mutant of Escherichia coli.
Salguero I, López Acedo E, Guzmán EC. | 11/24/2012 |
| The report three independent methods that establish that Y(356) is the predominant location (85-90%) of the radical, with the remaining 10-15% delocalized onto Y(731) and Y(730) in alpha2. | Equilibration of tyrosyl radicals (Y356•, Y731•, Y730•) in the radical propagation pathway of the Escherichia coli class Ia ribonucleotide reductase.
Yokoyama K, Smith AA, Corzilius B, Griffin RG, Stubbe J., Free PMC Article | 03/10/2012 |
| The authors propose that RecA is required to maintain the integrity of the reversed forks in the nrdA101 mutant under certain restrictive conditions, supporting the relationship between DNA replication and recombination enzymes. | RecA-dependent replication in the nrdA101(Ts) mutant of Escherichia coli under restrictive conditions.
Salguero I, Guarino E, Guzmán EC., Free PMC Article | 07/16/2011 |
| The authors show that the binding of DnaA on the NrdAB promoter can either activate or repress transcription as a function of its concentration and its nucleotide-bound state. | DnaA-ATP acts as a molecular switch to control levels of ribonucleotide reductase expression in Escherichia coli.
Olliver A, Saggioro C, Herrick J, Sclavi B. | 10/30/2010 |
| N-terminus verified by Edman degradation on complete protein | Protein B1 of ribonucleotide reductase. Direct analytical data and comparisons with data indirectly deduced from the nucleotide sequence of the Escherichia coli nrdA gene.
Sjöberg BM, Eriksson S, Jörnvall H, Carlquist M, Eklund H. | 11/5/2007 |
| analysis of key residues in the dimerization process of ribonucleotide reductase protein R1 | Nucleotide-dependent formation of catalytically competent dimers from engineered monomeric ribonucleotide reductase protein R1.
Birgander PL, Bug S, Kasrayan A, Dahlroth SL, Westman M, Gordon E, Sjöberg BM. | 01/21/2010 |
| it is proposed that an altered NDP reductase, as a component of the replication machinery, impairs the progression of the replication fork, contributing to the lengthening of the C period in the nrdA101 mutant at the permissive temperature | Defective ribonucleoside diphosphate reductase impairs replication fork progression in Escherichia coli.
Guarino E, Jiménez-Sánchez A, Guzmán EC., Free PMC Article | 01/21/2010 |
| There is an indirect relationship between NDP reductase and the chromosome segregation machinery through the maintenance of the proposed replication hyperstructure. | Differences in the degree of inhibition of NDP reductase by chemical inactivation and by the thermosensitive mutation nrdA101 in Escherichia coli suggest an effect on chromosome segregation.
Riola J, Guarino E, Guzmán EC, Jiménez-Sánchez A., Free PMC Article | 01/21/2010 |