| Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli. | Interaction with the carboxy-terminal tip of SSB is critical for RecG function in E. coli.
Bonde NJ, Henry C, Wood EA, Cox MM, Keck JL., Free PMC Article | 05/11/2023 |
| DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication forks in Escherichia coli. | DNA Helicase-SSB Interactions Critical to the Regression and Restart of Stalled DNA Replication forks in Escherichia coli.
Bianco PR., Free PMC Article | 03/20/2021 |
| Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD. | Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD.
Romero ZJ, Chen SH, Armstrong T, Wood EA, van Oijen A, Robinson A, Cox MM., Free PMC Article | 10/24/2020 |
| Data show that cells lacking ATP-dependent DNA helicase RecG (RecG) have indicated substantial over-replication of sequences in the termination region. | Chromosomal over-replication in Escherichia coli recG cells is triggered by replication fork fusion and amplified if replichore symmetry is disturbed.
Midgley-Smith SL, Dimude JU, Taylor T, Forrester NM, Upton AL, Lloyd RG, Rudolph CJ., Free PMC Article | 08/31/2019 |
| results provide mechanistic insights into the modes of interaction of RecG with the replication fork, suggesting a novel role of RecG in the repair of stalled DNA replication forks. | Dynamics of the Interaction of RecG Protein with Stalled Replication Forks.
Sun Z, Hashemi M, Warren G, Bianco PR, Lyubchenko YL., Free PMC Article | 05/12/2018 |
| Data suggest that RecG and RuvABC catalyze alternative steps in DNA repair/recombination and collaborate to stabilize DNA during repair of double-strand DNA breaks; RecG may prevent DNA amplification at D-loops formed by recombination and at arrested replication forks. (RecG = RecG DNA helicase; Ruv = Holliday junction DNA helicase subunit) [REVIEW] | RecG controls DNA amplification at double-strand breaks and arrested replication forks.
Azeroglu B, Leach DRF., Free PMC Article | 08/12/2017 |
| interaction occurs via the wedge domain of RecG and the intrinsically disordered linker (IDL) of SSB, in a manner similar to that of SH3 domains binding to PXXP motif-containing ligands in eukaryotic cells. | SSB and the RecG DNA helicase: an intimate association to rescue a stalled replication fork.
Bianco PR, Lyubchenko YL., Free PMC Article | 07/22/2017 |
| Data show that single-stranded DNA binding proteins (SSB)-interacting proteins RecO, RecG, PriA, and accessory helicase Rep do not correlate with replication at relication forks. | Are the SSB-Interacting Proteins RecO, RecG, PriA and the DnaB-Interacting Protein Rep Bound to Progressing Replication Forks in Escherichia coli?
Bentchikou E, Chagneau C, Long E, Matelot M, Allemand JF, Michel B., Free PMC Article | 05/14/2016 |
| Once RecG has regressed the fork, it will dissociate leaving the now relaxed, Holliday junction-like DNA, available for further processing by enzymes such as RuvAB. [review] | I came to a fork in the DNA and there was RecG.
Bianco PR., Free PMC Article | 02/6/2016 |
| Regression of replication forks stalled by leading-strand template damage: both RecG and RuvAB catalyze regression, but RuvC cleaves the holliday junctions formed by RecG preferentially. | Regression of replication forks stalled by leading-strand template damage: I. Both RecG and RuvAB catalyze regression, but RuvC cleaves the holliday junctions formed by RecG preferentially.
Gupta S, Yeeles JT, Marians KJ., Free PMC Article | 02/7/2015 |
| These results suggest that RecQ acts upstream of RuvABC, RecG and XerC proteins, a finding that is compatible with its primary role in initiation of the RecF recombination pathway. | RecQ helicase acts before RuvABC, RecG and XerC proteins during recombination in recBCD sbcBC mutants of Escherichia coli.
Buljubašić M, Zahradka D, Zahradka K. | 08/9/2014 |
| RecG co-localises with sites of DNA replication in Escherichia coli. | Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus.
Upton AL, Grove JI, Mahdi AA, Briggs GS, Milner DS, Rudolph CJ, Lloyd RG., Free PMC Article | 07/19/2014 |
| Abolishing PriB leads to suppression of the recG null phenotype. | Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase.
Mahdi AA, Briggs GS, Lloyd RG., Free PMC Article | 04/6/2013 |
| data are consistent with RecG and ssDNA exonucleases acting to limit PriA-mediated re-replication of the chromosome and the consequent generation of linear DNA branches that provoke recombination and delay chromosome segregation | RecG protein and single-strand DNA exonucleases avoid cell lethality associated with PriA helicase activity in Escherichia coli.
Rudolph CJ, Mahdi AA, Upton AL, Lloyd RG., Free PMC Article | 03/26/2011 |
| Role in converting the initial single-strand DNA-protein cleavage complex into a double-strand break prior to repair by homologous recombination. | Analysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complex.
Sutherland JH, Tse-Dinh YC., Free PMC Article | 09/20/2010 |
| The authors show that the extensive DnaA-independent stable DNA replication observed without RecG can lead to replication of any area of the chromosome. | Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase.
Rudolph CJ, Upton AL, Lloyd RG., Free PMC Article | 03/8/2010 |
| RecG decreases the number of replication forks in UV-irradiated cells by limiting UV-induced, DnaA-independent initiation of replication. | Pathological replication in cells lacking RecG DNA translocase.
Rudolph CJ, Upton AL, Harris L, Lloyd RG., Free PMC Article | 01/21/2010 |
| Data suggest that the processivity of RecG on branched DNA substrates is dependent on the ability of its wedge domain to establish strong binding at the branch point. | DNA binding by the substrate specificity (wedge) domain of RecG helicase suggests a role in processivity.
Briggs GS, Mahdi AA, Wen Q, Lloyd RG. | 01/21/2010 |
| Inactivation of recG stimulates recombinant formation about five-fold | Inactivation of recG stimulates the RecF pathway during lesion-induced recombination in E. coli.
Bichara M, Pinet I, Origas M, Fuchs RP. | 01/21/2010 |
| manner and timing of the interaction of RecG with DNA at stalled replication forks | Characterization of the ATPase activity of the Escherichia coli RecG protein reveals that the preferred cofactor is negatively supercoiled DNA.
Slocum SL, Buss JA, Kimura Y, Bianco PR., Free PMC Article | 01/21/2010 |
| allows repair of damaged replication forks to proceed without recourse to potentially mutagenic recombination | Effect of host species on recG phenotypes in Helicobacter pylori and Escherichia coli.
Kang J, Tavakoli D, Tschumi A, Aras RA, Blaser MJ., Free PMC Article | 01/21/2010 |